🎉The new and improved CoVariants.org is here! 🎉

We're hoping to make this a one-stop location to track not only the 'headline' variants, but many different #SARSCoV2 mutations & variants that scientists are keeping an eye on.

Let's take a tour of the site!

1/12
The buttons on the left will take you to pages focused on key variants & mutations, while the menu at the top will help you jump between info pages (FAQ) & pages compiling together information about many variants (ex: Per country).

Let's take a look at the 20A.EU1 page

2/12
Here, we can
- Click through to a dedicated @Nextstrain build for the variant (1)
- See a list of the defining mutations (2)
- Learn a bit about the variant & see links to papers (3)
- See a distribution of 20A.EU1 per country (4)
- See a protein model! (pic 2)

3/12
On other pages we can see even more information.

On the S:N501 page, we can see even more information & links about the S:N501 mutation itself (pic 1), & detailed information on the 3 variants that have this mutation (501Y.V1 [B.1.1.7], 501Y.V2, 501Y.V3) (pic 2).

4/12
Often we're curious about the trends of these variants in particular countries. We can check out 'Per country' for an interactive overview of the variant frequencies in select countries.

You can mouse-over to find out the sequence counts, & turn on/off variants!

5/12
We can also look at information 'Per Variant' with what frequency of each country's sequences fall in that variant.

Again, mousing over give more detailed information, and countries can be turned on and off!

6/12
Finally - we've added a table where you can easily see what mutations are shared between some of the variants getting the most important attention right now. Use the toggle to change how the mutations are sorted!

We'll expand this table in future!

7/12
You can find out more information about the this website - FAQs, citation & data information, useful resources, and more - in the FAQ pages!

8/12
The #SARSCoV2 pandemic & the research on it is ongoing & changes every day. We're making every effort to keep CoVariants updated, but welcome PR requests & issues to ensure it is as useful as possible!

See links at the top right of each section!

9/12

github.com/hodcroftlab/co…
Further, we've already got a *lot* of updates in the works, including a better breakdown of the variants (buttons for each one!) & more variants in the mutation table!

We hope to make CoVariants even more useful for #SARSCoV2 communication & research.

10/12
CoVariants is also mobile & tablet friendly 📱, so you can be sure to keep up with the latest graphs & information even on-the-go! 😆😉

11/12
And of course, this work was not done alone. Huge thanks to everyone who's helped so far.

In particular, massive 👏🏻👏🏻 to @ivan_aksamentov for the web design.

Also big thanks to @hamesjadfield for the mutation table idea, & @richardneher & @trvrb for feedback & support!

12/12
PS - Don't forget to update your bookmarks! CoVariants.org will take you straight to the new page, but the Github (github.com/hodcroftlab/co…) has changed, so you'll have to click through.

To go straight there, point your bookmark to CoVariants.org!

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More from @firefoxx66

27 Jan
The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

nextstrain.org/groups/neherla…
In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18
Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18
Read 18 tweets
25 Jan
As we head deeper into 2021, a gentle reminder to double-check your #SARSCoV2 sequencing scripts for hardcoded '2020's! 😬

We've seen a real uptick recently in sequences with sampling dates in Jan 2020, with divergence that clearly indicates they meant 2021! 📅🤦🏻‍♀️
"How can we tell?" you might wonder. Actually, these cases are pretty easy to spot!
Let's take a look at two sequences reported as being from Jan 2020 - 1 in green, 2 in blue. (Spoiler, green is the imposter.)
This view is 'date view' where sequences are plotted on the X-axis by the date they were sampled. Then, we try and infer how they're connected using their genetic information - specifically, what mutations they share & don't share.
Read 10 tweets
22 Jan
I got a lot of messages last week about a 'new variant' in Bavaria, Germany.

Notably, scientists at @ChariteBerlin have announced this is *not* a new variant. Link may stop working so screenshot attached.

Read on to see the sequences...

1/4

spiegel.de/wissenschaft/c…
3 seqs indicated in red are apparently from the hospital. They're coloured by deletion at position 69, which likely caused them to be flagged (501Y.V1 has it too). However, they're related to other sequences in Germany & Turkey, also w the deletion.

2/4

nextstrain.org/groups/neherla…
We do see the 69/70 deletion has appeared independently previously. While this is interesting, I don't think it increases concern significantly about this group of sequences, which are part of a larger cluster that's been circulating in Germany since spring 2020.

3/4
Read 4 tweets
21 Jan
The S:N501 and S:E484 builds are now updated with data from 20 Jan! 🎉

There are almost 400 new non-UK and non-South Africa sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

And 8 new sequences in 501Y.V3 & 20B/S.484K (primarily circulating in Brazil)

#SARSCoV2

1/19
There are 394 new non-UK sequences in 501Y.V1 from the Netherlands, Denmark, Singapore, Australia, Italy, Spain, France, Ireland, Finland, Sweden, the USA, Switzerland, India, Brazil, Slovakia, & Belgium

2/19

nextstrain.org/groups/neherla…
Denmark has 125 new sequences (orange) - many linking to older sequences & clusters, indicating ongoing local transmission (pic 1).

Netherlands has 14 new sequences (yellow) - many linking to older sequences and clusters, likely indicating local transmission (pic 2).

3/19
Read 19 tweets
18 Jan
A #SARSCoV2 variant with a combination of mutations in Spike (S13I, W152C, L452R) has been making headlines & twitter rounds today, so - a fresh-from-the-oven 🥖 S:L452R focal build is now up - let's take a look:

1/10

This combination of mutations falls in 20C, and is found predominantly in the US, especially in California. Here's a zoomed view and link.

2/10

nextstrain.org/groups/neherla…
Importantly, we *don't yet know* if this variant is being pulled along with a general rise in cases, or some other environmental or behavioural change - or whether the mutations change the behaviour of the virus, like transmissibility.

Be wary of headlines claiming this!

3/10
Read 10 tweets
17 Jan
The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

nextstrain.org/groups/neherla…
There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16
Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16
Read 16 tweets

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