#WCLC20 The plenary presentation by @GoldmanLisa on patient-directed research and lessons in partnership is a can't miss and gives important insight into the evolution of clinical research #LCSM @IASLC @OncoAlert
#WCLC Great to see so many active biomarker specific patient groups like @ros1cancer @ALKLungCancer @Exon20Group @EGFRResisters @mcrouse53 @RetRenegades @alk_fusion @kRasKickers @NTRKers @METCrusaders. We also need to reach patients that are less tech savvy or who lack access.
#WCLC There are many different ways that patients can be involved in research including biobanks, registries and RWE studies. As a great example: project PRIORITY led by the @EGFRResisters #LCSM
#WCLC20 Due in part to discordance in actual vs reported toxicities, projects like PRIORITY can provide insight into real world toxicity and QOL. #LCSM
#WCLC20 The @EGFRResisters also fully sponsor the @EGFRSummit with junior faculty and trainees are mentored by experts like @Jbauml @ZPiotrowskaMD @HelenaYu923 @LeciaSequist @maryjofidlerMD @RamalingamMD @christine_lovly @JoelNealMD #LCSM
#WCLC20 Clinical research is an active partnership between researchers and patients. As @GoldmanLisa put it, "Patient input makes research more relevant and rewarding." Well said. #LCSM @IASLC @OncoAlert

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More from @StephenVLiu

29 Jan
#WCLC20 CHRYSALIS trial results with amivantamab in #EGFRex20 NSCLC post-platinum based chemotherapy presented by @JSabari. Amivantamab has FDA breakthrough designation for this indication. @IASLC #LCSM @OncoAlert Image
#WCLC20 Amivantamab is an EGFR-MET bispecific antibody given intravenously weekly x 1 month then q2w. This is a single arm phase II for patients with #EGFRex20 mutant NSCLC after prior chemotherapy. #LCSM ImageImageImage
#WCLC20 Amivantamab was reasonably well tolerated. G3 TEAE in 35% but treatment-related rate only 16%. Drug related AE leading to discontinuation only 4%. Mostly G1-2 adverse events including rash, paronychia. #LCSM ImageImage
Read 4 tweets
29 Jan
#WCLC20 Dr. Nakagawa presents results from the DESTINY-Lung01 trial of trastuzumab deruxtecan (T-DXd, Enhertu). T-DXd is a HER2 antibody-drug conjugate (ADC). #LCSM @IASLC @OncoAlert Image
#WCLC20 This study had two cohorts. Here, we focus on Cohort 1 (HER2-overexpressing = IHC3+ or IHC2+). Primary response rate was ORR. #LCSM Image
#WCLC20 As a reminder, we saw results from Cohort 2 (HER2-mutant) at #ASCO20 where they reported an ORR of 61.9% with mPFS 14.0m, which led to the inclusion of T-DXd in the @NCCN guidelines for #HER2 mutant NSCLC. #LCSM Image
Read 8 tweets
29 Jan
#WCLC20 Highly anticipated results of oral TKI mobocertinib (TAK-788) in #EGFRex20 mutant NSCLC after prior platinum based chemotherapy. Huge unmet need and as @Jbauml reported at this meeting, likely underdiagnosed. #LCSM @IASLC @OncoAlert ImageImageImage
#WCLC20 Cohort being discussed here is #EGFR exon 20 insertion NSCLC after prior platinum therapy and the EXCLAIM extension cohort. Many patients also had prior TKI therapy and prior immunotherapy. @IASLC ImageImageImage
#WCLC20 Here are the topline results. RR 23-26% by IRC, RR 32-35% by investigator, DOR by IRC was 17.5m (!) and mPFS 7.3m -- for #EGFRex20, no clear standard. Mobocertinib certainly has some activity here. #LCSM Image
Read 6 tweets
29 Jan
#WCLC20 Results from the phase III non-inferiority J-AXEL study of salvage nab-paclitaxel vs docetaxel in NSCLC. Large study (n>500) with a 1:1 randomization. #LCSM @IASLC @OncoAlert ImageImageImage
#WCLC20 Positive study! Shows non-inferiority in OS with nab-paclitaxel over docetaxel (median 16.2m vs 13.6m). PFS favors nab-pac (HR 0.76). #LCSM ImageImage
#WCLC20 RR favors nab-paclitaxel (30% vs 15%) and in this study, unlike the registrational trial, no real difference between squamous and non-squamous (both 30%, both better than docetaxel). #LCSM Image
Read 4 tweets
29 Jan
#WCLC20 Excited about this one: phase I results of the HER3 ADC patritumab deruxtecan (HER3-DXd; U3-1402) in #EGFR mutant #NSCLC presented by @HelenaYu923 #LCSM @IASLC @OncoAlert Image
#WCLC20 Presentation here is on the combined dose escalation and expansion at the 5.6 mg/kg dose with #EGFR mutant NSCLC. Includes 56 evaluable patients. Median f/u 5 months. #LCSM @IASLC ImageImageImage
#WCLC20 Fairly heavily pretreated population with both TKI and chemotherapy and many with IO as well. Biopsy required for HER3 expression (violin plot on right) and nearly all were HER3 positive. #LCSM Image
Read 6 tweets
29 Jan
#WCLC20 Results from phase I study of the TROP2 ADC datopotamab deruxtecan (Dato-DXd; DS-1062) in NSCLC by @AlexSpiraMDPhD #LCSM @IASLC @OncoAlert Image
#WCLC20 This ADC includes an anti-TROP2 IgG1 and a topo-1 inhibitor payload. Phase 1 design shown here. Mostly non-squamous, included some #EGFR+, heavily pretreated including many with CNS metastases. Less intensity at higher 8mg dose, as one would expect. #LCSM ImageImageImageImage
#WCLC20 Safety shown here and manageable but I would say still notable, especially at 8mg (G3+ AEs 34%) including ILD noted in 8% (but 3 grade 5 cases in the 8mg/kg cohort). #LCSM ImageImage
Read 5 tweets

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