What’s happening in India?
Is the pandemic burning out? How? Where is the post Diwali surge that we worried about? #COVID19
I wrote about India in August. I was convinced that cross reactive immunity was at play. Along with younger age & less obesity, this is protecting India
People are often quick to criticize the numbers. But keep in mind you can miss asymptomatic or mildly symptomatic cases. But you cannot hide 10 times more deaths or ICU admissions.
This is real. And is not explained by just younger age and less obesity.
This is more than that. Sometimes epidemiological observations are much more powerful and give better insight than lab studies.
India is a country where social distancing outdoors or indoors is not easy.
We are seeing this play out. It’s staring at us: Cross reactive immunity.
Cross reactive immunity from prior corona virus infections may not be enough to prevent someone from getting COVID. But as I have written before it can protect from severe COVID. Prevent hospitalizations, IVU admissions, and deaths.
Even still it is very important that people in India try their best to social distance, wear masks, and get vaccinated as soon as possible. We already have the worry of mutant strains. @rishika625ndtv.com/video/news/cor…
Do not take chances.
Here is a thread on cross reactive immunity from July by @PSampathkumarMD
1/ When you get vaccinated you don’t make just one type of antibody. You make a whole portfolio of antibodies against various epitopes. So unless there is a huge number of mutations, vaccines will protect you, especially from severe disease. #VaccinesWork#Covid_19
2/ You not only make matching keys to fit multiple locks when all you need is to open just one lock, but you also make multiple slightly different keys for each lock in the process of making the perfect key. All of this redundancy is why vaccines work even if the virus mutates.
3/ The sheer number of COVID infections in such a short period of time, and the lack of significant pre existing immunity means a lot more viral replications, & a lot more opportunities for mutations to arise. Not every mutation will change the behavior of the virus. But some do.
This is the first and best real world evidence that vaccines are highly effective in protecting people from severe COVID. Israel has led the world in vaccinations. I am very impressed with these results. #VaccinesWork@ASlavitt@TimesofIsraelgoogle.com/amp/s/www.time…
As of now almost 40% of Israel has been vaccinated. Just phenomenal.
My suggestion. Keep razor focus on vaccinating as many people as possible.
Don’t worry about which vaccine.
Don’t worry about mutants. (Let scientists do the worrying)
Don’t worry about mild COVID
If we can stop deaths from COVID then COVID becomes the common COLD
Looks like wearing masks does protect from colds and influenza.
Looks like Asian countries knew something we didn’t all along.
We don’t have to wear a mask forever, but once COVID is done if vulnerable people choose to wear a mask that’s A-OK.
With certain benign interventions (like mask wearing) that make logical sense and have observational data, the absence of randomized trial data doesn’t mean they aren’t the prudent course of action.
Absence of RCT evidence is not the same as evidence of absence. @jeremyphoward
In many Asian countries mask wearing pre COVID was just routine. Many people just did it. And it was not stigmatizing.
Even within Asia, wearing a mask pre COVID was common in Hong Kong but signaled you were not well in Singapore.