Thread by @MonicaGandhi9

And then wanted to explain why you should be beaming ear-to-ear about vaccine data. Why would an infection trigger all of this testing, masking, life halting? Because severe illness/hospitalizations/deaths occur. All vaccines to date prevented hospitalizations/deaths completely.

Severe illness prevented completely in Moderna/Pfizer/AztraZeneca trials; 85% across regions (even in South Africa - South Africa variant there) in J&J trials and immune response from 1 dose may keep on giving (remember, outcomes evaluated 14-28 days out due to expediency)

But as I wrote yesterday, immunogenicity from 1 dose of J&J likely extends beyond 14-28 days - keeps on going so likely more protection over time - see graphs in this paper. Two-dose trial still going. Finally, S. Africa variant is one with less protection
nejm.org/doi/full/10.10…

from moderate disease in J&J trial with 1 dose and Moderna already making booster shot for this variant if needed (others can too nimbly). Finally, control in a population needs less efficacy than what we've seen with these vaccines.
wsj.com/articles/moder…

And why will restrictions end? Because restrictions put into place not because COVID is mild, but because of hospitalizations/deaths/severe disease. As those stop, it won't be tenable, prudent or cost-effective to test everyone when SARS-CoV-2 rendered toothless -public health

will need to resume work on terrible health maladies like housing and food insecurity, other infections (HIV, malaria, tuberculosis to name some), childhood vaccinations, overdose prevention, mental health. many of which exacerbated in this pandemic.
nytimes.com/interactive/20…