A thread for #MECFS, & related, research papers from w/c 25th Jan.

Links will be to our forum discussion threads, where abstracts, links to paper, analysis and discussion can be found. Inclusion in this list does not equal recommendation.

1/
"In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling" by Hanson et al

s4me.info/threads/in-dep…

2/
"ME/CFS: The Human Herpesviruses Are Back!" by M E Ariza.

s4me.info/threads/articl…

3/
Short report: "Exosome-associated Mitochondrial DNA is Elevated in Patients with ME/CFS and Stimulates Human Cultured Microglia to Secrete IL-1β" by Theoharides et al.

s4me.info/threads/exosom…

4/
"The Reification of the Clinical Diagnosis of ME/CFS as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups" by Maes et al.

s4me.info/threads/the-re…

5/
"Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS" by Bergquist et al.

s4me.info/threads/hypoth…

6/
"F-FDG brain PET hypometabolism in patients with long COVID" by Guedj et al.

s4me.info/threads/f-fdg-…

7/
"The draft updated NICE guidance for ME/CFS highlights the unreliability of subjective outcome measures in non-blinded trials" by Vink & Vink-Niese

s4me.info/threads/the-dr…

8/
“Updating the National Academy of Medicine ME/CFS prevalence and economic impact figures to account for population growth and inflation” by Jason & Mirin.

s4me.info/threads/updati…

9/
“Discernment of Mediator and Outcome Measurement in the PACE trial” by Carr et al.

s4me.info/threads/discer…

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More from @s4me_info

18 Jan
A thread for #MECFS, & related, research papers w/c 11th Jan.

Links will be to our forum discussion threads, where abstracts, links to paper, analysis and discussion can be found. Inclusion in this list does not equal recommendation.

1/
"Reversible widespread brain 18F-FDG PET hypometabolism in chronic fatigue syndrome treated by hyperbaric oxygen therapy" by Guedj et al.

s4me.info/threads/revers…

2/
"Salivary DNA loads for human herpes viruses 6 and 7 are correlated with disease phenotype in ME/CFS" by Lee, Lacerda, Nacul, et al.

s4me.info/threads/saliva…

3/
Read 4 tweets
23 Aug 20
Why are the #MECFS patient community concerned for #LongHaulers who might try to exercise themselves back to health?

Watch these two videos that look at the evidence against Graded Exercise Therapy for the often post-viral ME/CFS.

#LongCovid #PACEtrial

dialogues-mecfs.co.uk/films/graded-e…
Independent re-analysis of the the largest trial that claims benefits of GET and CBT.

"The modest treatment effects obtained on self-report measures in the PACE trial do not exceed what could be reasonably accounted for by participant reporting biases."

bmcpsychology.biomedcentral.com/articles/10.11…
A 2017 analysis of patient surveys by @keithgeraghty shows GET is rated negatively by the majority of patients (54%–74%), while pacing "is the most favoured treatment with the lowest negative response rate and the highest reported benefit (44%–82%)."

journals.sagepub.com/doi/10.1177/13…
Read 6 tweets

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