Really enjoying this latest podcast on @PeterAttiaMD’s #Drive so far.

Now up to the part where Dr Yassine is discussing GLUT1 regulation with the brain... (about 22m in)...
Hmmm...

“... the brain is not efficient at using fat as a source of ATP.”
“... nevertheless when the brain goes through crises and cannot utilize glucose, we have a mechanism to extract ATP from fat. But the result is a price tag, the result is oxidative stress.”

Please visit this around minute 24 to get the full context.
Starting around minute 31 they get into my favorite subject of lipids, lipoproteins, and — in particular — apolipoprotein load balancing. Certainly something my life is mapped around right now. ;)
At 34m @PeterAttiaMD expresses his hope for an ApoCIII assay soon to add to the “arsenal”— I couldn’t agree more!

For that matter, I’ll bet an obvious prognostic ratio to emerge will be ApocIII/ApoB*

*Go ahead and bookmark this tweet for later reference. You heard it here first

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More from @DaveKeto

23 Jan
1/ So I did my 3D body scan this morning (and no, not posting pictures or sharing absolute numbers).

This will have been 5 days since isocaloric carb swapping in low-ish carb for keto.

Waist +0.9"
Stomach +1.2"
Hip +0.4"

Wow... in 5 days? This was pretty unexpected...
2/ Just a reminder-- this is the most controlled experiment between phases I've had to date. Replicated sleep and exercise timing and patterns, even water quantity and consumption window.

Given this shorter time span for the phase, I wasn't expecting much difference to emerge...
3/ Although, to be sure, both my wife and I noticed I was putting on more weight in the midsection even before the scan. I'm holding at around 199.6 for two days in a row, so while I gained around 2.5lbs initially, it seems to have leveled off.
Read 8 tweets
21 Jan
1/ Well... this is awkward...

I'm gaining weight on my "bonus" carb-swap phase in spite of it being isocaloric and everything else being nearly identical (exercise, sleep, supplements, even liquid consumption) w/ prior keto phases.

And I'm gaining it pretty fast, actually...
2/ And actually, the "low carb" phase is technically slightly lower in calories than the keto phase.

And this experiment is as controlled as I get
- Fixed eating times with fixed meals (9am/2pm/7pm)
- Fixed exercise (walking) with same route and time (~3pm)
- Comparable sleep
3/ Sure -- like many reading this, I'd assume this is in large part glycogen and water gain. But I'll concede this is impressively fast given I'm at maintenance level of calories -- which was literally just demonstrated in the run-up phases before this one.
Read 4 tweets
20 Jan
1/ #ReadingThread

This paper by @zinocker, @kariannesve, @simondankel is proving an interesting read. Before I get too much further, I'm going to turn it into a "reading thread" and post some of these quotes as I go...

(Big hat tip to @bigfatsurprise) academic.oup.com/ajcn/advance-a…
2/ "In this paper we propose a novel model, the homeoviscous adaptation to dietary lipids (HADL) model, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that serve to maintain cell membrane fluidity and hence optimal cell function."
3/ Later in the abstract: "Hence, circulating levels of LDL cholesterol may change for nonpathological reasons. Accordingly, an SFA-induced raise in LDL cholesterol in healthy individuals could represent a normal rather than a pathologic response."
Read 15 tweets
20 Jan
1/ Some preliminary data from the #EatingWindowExperiment while we wait for the labs to come back.

These are the mean avgs for each period taken over the last 3 days of each phase (wake/7am/9am/2pm/7pm/10pm) compared.

Needless to say, this is some fascinating stuff...
2/ I was taking glucose and ketones (BHB) via @KetoMojo, lipids via CardioChek from @ptsdiagnostics

Where my test and meal times were the same, I'd take the blood test just before the meal.

(For study design, see cholesterolcode.com/eating-window-…)
3/ Again, I'm eating exactly the same thing in each phase, exercising the same, sleeping the same, etc -- the only difference is in the 10.5hr window my meals are 5 hours apart. In the 4.5hr window my meals are 2 hours apart.

(I added the 0.5 to reflect eating time of last meal)
Read 9 tweets
18 Jan
1/ Thread — #EatingWindowExperiment initial thoughts...

(If you need a primer, see the experiment design here: cholesterolcode.com/eating-window-…)

All in all, this turned out pretty well. Yes, I had to amend in tighter fasting window timing after the first day....
2/ Going from evening to midday was a very meaningful change with regard to how challenging it would be.

(For details on that, see cholesterolcode.com/eating-window-…)

I normally don’t like fasting more than 14 hours. But this window of 10am-2pm (3 meals) was surprisingly easy.
3/ I think the key was to intentionally eat enough calories that would have normally been over the course of a day anyway. That said, I might have been able to further restrict how much I eat in the last meal (2pm).
Read 8 tweets
27 Nov 20
1/ Someone recently tweeted that hospital food is unhealthy, but that they aren't going to change lifelong habits, thus showcasing photos of this isn't very helpful.

That's actually lingered with me for several days. Maybe because I feel exactly the opposite...
2/ Very little demonstrates the emphasis of nutrition as the food you serve under one's care. If we already know how much diet impacts the very disease that brings people to the hospitals (and we do), why -- of all places -- would we want to enable this negative outcome there?
3/ I've seen countless people adopt healthy habits when simply provided the knowledge and opportunity to do so. What better place to build on this than one dedicated to your returning you to health? At the barest of minimums, the patient should have a choice.
Read 4 tweets

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