Almost 1 year ago, Feb 26, 2020, authors wrote in a top journal that the coronavirus posed “limited threat outside of China” & “wearing mask in public does not prevent people from getting” #COVID19

➡️We should have listened to the actual aerosol scientists instead on masks! 🤦🏻‍♂️
2) This above JAMA short article and info graphic was widely read and cited in the media. jamanetwork.com/journals/jama/…

Meanwhile many in Asia — especially Japan 🇯🇵 South Korea 🇰🇷 and Taiwan 🇹🇼 (& China) recognized airborne transmission early because their aerosol experts led the way.
3) Meanwhile, a medical expert for all the top airlines in the world was quoted by Bloomberg to “forget face masks”. I highly doubt Dr David Powell of @IATA had any real expertise or experience in aerosol transmission or epidemiology.
4) Yes, some say the former Surgeon General and Fauci once said something similar, though they were a little different—they were mostly saying you don’t need to wear it yet / save it for healthcare workers, rather than it doesn’t work. Big difference. But lay media misinterpreted
5) I think we need to discuss how we find and cite experts. I have a doctorate in epidemiologist (plus a second one in nutrition), but I don’t pretend to know everything—and I don’t. I listen to expert but I keep my eyes open to diverse fields. Medicine doesn’t know aerosols...
6) Just like aerosol experts don’t know immunology. Immunologists are not the same as virologists, and some specialize in lab testing and some more in genetic evolution, and some specialize more in vaccine development. But virologists aren’t clinical trial epidemiologists....
7) And most of them certainly don’t know health policy & the inside-baseball politics. And so when it comes to certain areas of this pandemic, some know more than others, and many who might know CAN DISAGREE & DISAGREE IN RESPECTFUL (read: professional & non dismissive ways).
8) And even if someone does have expertise, they may not have their ears open or ears to the ground globally on different sources of data and information (not all good information is published in medical journals, and not all info published is good—see top post for example)...
9) Some info on internet is good, but a crap ton of info on the net is total junk and often dangerous conspiracy nonsense. All this makes the average lay public reader super confused. The media tries to do the best they can, but often they have tendency to turn to convenience...
10) Often media has the tendency to turn to their in-house medical experts, which for most medical issues they are great for, but other times not so much. Or they use whatever experts are pitched to them—sometimes good when it’s pitched from a university communications office...
11) But sometimes the media is pitched by PR gurus like paid publicists. And this is sometimes tricky, cuz we know that can be hit and miss. But they often get themselves on TV or media more. (I have not have one for any appearances, FYI). Infor is hard to distill for producers.
12) And sometimes the hardworking TV producers & writers might be sometimes misled by false narratives from a PR agent / publicist, or other even other scientists, who have vendettas to attack and denigrate others they disagree with.
13) One group of pandemic experts I rarely see on TV? Aerosol experts — who are traditionally environmental engineers who work in air pollution and climate change research — but also virus containing aerosols and design HEPA filters & upper air germicidal UV light to kill viruses
14) I did not personally know of any aerosol experts before the pandemic, but I have discovered people like @kprather88 @jljcolorado @ShellyMBoulder @CorsIAQ @Don_Milton @HuffmanLabDU @linseymarr @j_g_allen & others, to be incredibly humble, open minded & professionally modest...
15) But experts like them have been shouting since very start of #COVID19 outbreak that the **respiratory** virus was airborne. They know cuz they’ve studied it for years, while virologists (who are molecular biologists by training) have mostly not studied aerosols much at all.
16) Thus these aerosol scientists got frustrated because almost everyone in the media was mostly ignoring them and their aerosol warnings that #SARSCoV2 was airborne. thus penned a 239 person open letter to WHO and the world warning this finally in July—but 6 months too late 😢
17) Late is better than never, but they weren’t heeded by the CDC (albeit muzzled by Trump WH/HHS as we know) until October 5th!!! That’s almost 9 months after the first can in the US in mid Jan! We lost 9 months of airborne warnings to the public!!! Damnit, that’s shameful.
18) And the shame and blame is not on one individual or one organization. It was on all of us from our insular media tendencies to grab whatever “Dr”happens to be available for a TV hit, to being naive about the dismissive attitudes of some in virology to aerosols (oh yes)...
19) ...to the general dismissive nature of anything that isn’t published but merely anecdotal (we knew from lots of reports in China and South Korea about asymptomatic transmission—before someone had any cough or sneeze—via again simple aerosol breathing), but were dismissed.
20) Someday there will need to be a 9-11 Commission on all of this in our reckoning of missteps, and I hope public policy experts like @kavitapmd and @ASlavitt and @AliNouriPhD who understand public policy more than any academic scientist, help lead it someday of what when wrong.
21) Ultimately, we need to prevent future pandemics, and the “infodemic” is not just right wing anti-mask misinfo, HCQ misinfo, Scott Atlas natural herd misinfo, but also our poor info filtering that led to all this tragedy of ignoring warning, dismissing masks, & airborne risks.
22) Some of you know why I feel so passionate on this, because it is so personal to me (and my family who suffered) from all the early harassment when i tried to warn a pandemic was coming. I’ll continue this another day, but we need to solve this. nymag.com/intelligencer/…
23) A sampling of headlines from Jan-March 2020 that supports my points above. A pandemic- a “thermonuclear level” one - was coming, yet so many people played it down and dismissed the risks. So frustrating.
24) And of course, the ultimate downplaying person was Trump. He was warned by his own NSC an ugly pandemic was coming and that the Coronavirus threat was real. Yet he did nothing. That was the most frustrating of all.

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More from @DrEricDing

8 Feb
OUTBREAK OF #B1351 VARIANT IN AUSTRIA 🇦🇹—B1351 🇿🇦 variant now identified in 293 cases in western Austria state of Tyrol—at least 140 active cases. Germany🇩🇪 is considering closing the border to Tyrol. Austria govt has issued urgent travel warning. #COVID19
tagesschau.de/ausland/europa…
2) “Experts rated the South African mutation as more dangerous than the British one. "The course of the disease should be more severe and the resilience to vaccinations should be higher. This mutation would set us back a long way."
3) Folks, Tyrol is a very popular Alpine tourism region of Austria that is bordered by Germany 🇩🇪 to the north, Switzerland 🇨🇭& Liechtenstein 🇱🇮 to the west, and Italy 🇮🇹 to the immediate south. If it’s in Tyrol, it’s likely all over Central Europe. And that what is worrisome.
Read 11 tweets
8 Feb
Immunocompromised 45 year old suffered from #COVID19 for 155 days before he died. The virus was changing very quickly inside the man's body—it acquired a big cluster of >20 mutations—resembled the same ones seen in #B117 & #B1351. (NPR audio Part 1 of 2)🧵
npr.org/sections/goats…
2) NPR report audio part 2 of 2:

Dr. Li couldn't believe what they found. "I was shocked," he says. "When I saw the virus sequences, I knew that we were dealing with something completely different and potentially very important."
3) “Toward the very end of his life, he was treated with monoclonal antibodies, from Regeneron," Li says. "And shortly thereafter, we saw evidence that suggested the virus was developing resistance or escaping from these antibodies as well."
Read 14 tweets
8 Feb
DIFFERENCE A VARIANT CAN MAKE: Early in the Oxford-AstraZeneca’s South Africa 🇿🇦 trial, before #B1351 variant became dominant, the AZ vaccine had a great efficacy of 75% risk reduction of #COVID19 after a single dose! But all that disappeared once B1351 variant showed up... 🧵 Image
2) Notably, #B1351 variant showed up midway through the trial and soon became the dominant strain after early November. And because it had the worrisome E484K “Eeek” mutation that could evade neutralizing antibodies, it then completely flipped the AZ vaccine results... Image
3) Notably, notice how the early 75% early efficacy seen by the vaccine completely got flipped around and was no longer any better late in the trial! Resulting in a crap 22% non-significant efficacy.

Late trial, 95% of infections sequences were #B1351 according to other data. Image
Read 8 tweets
8 Feb
Good summary on the efficacy of the 6 reported Phase 3 vaccines by the ever wonderful @MonicaGandhi9. Though caveats on #B1351 variant:

📍Moderna & Pfizer efficacy unknown for 🇿🇦; lab shows lower neutralization.

📍Sputnik not tested 🇿🇦

📍New AZ data shows low 22% #COVID19 Image
2) to be clear, the 22% efficacy against mild disease for the #B1351 variant was not significant in the new Oxford-AstraZeneca trial report. For severe diseases, it was okay for neutralization but no efficacy data yet. SA has switched vaccines they will be using meantime.
3) The South Africa 🇿🇦 variant has very evasive properties of seemingly evading prior immunity from natural infection. Prior infection was not protective against #B1351- not even for severe disease. But fortunately, several vaccines do work them n
Read 5 tweets
8 Feb
⚠️WARNING: If you attended a Super Bowl house party tonight (or partied in Tampa Bay), please quarantine yourself for the next 14 days.

Thanks,
Rest of America 🇺🇸
Rest of the World 🌍
#COVID19
2) Because the new and more contagious #B117 variant of the coronavirus is here. And it will dominate the US in a month, and dominate Florida in less than a month. Read:
3) it’s already everywhere in the US. Especially Florida.
Read 4 tweets
8 Feb
Damnit, why Florida, why?!?! Don’t you know the new more infectious #B117 variant is spreading the fastest already in Florida? Doubling every 9 days there. #COVID19
2) The new #B117 will become dominant by March 8th if not sooner... doubling every 9 days. https://t.co/XZY16Hf3aE
3) ⚠️WARNING: If you attended a Super Bowl house party tonight (or partied in Tampa Bay), please quarantine yourself for the next 14 days.

Thanks,
Rest of America 🇺🇸
Rest of the World 🌍
#COVID19
Read 5 tweets

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