FIRST ACTIVE DUTY DEATH FROM COVID—36 year old U.S. Air Force Tech Sergeant Michael Morris passed away from #COVID19 while stationed at Aviano NATO Base in Italy 🇮🇹. Morris is the first member of the U.S. Air Force to die of the virus while on active duty. nativenewsonline.net/currents/leech…
NEW—Austria 🇦🇹’s alarming #B1351 variant outbreak is growing. Not only 293 cases of 🇿🇦-origin variant identified in Tyrol—9 suspected cases of B1351 are currently suspected in 2 kindergartens in Salzburg, plus 9 more in 🇦🇹 military. #B1351TyrolSub#COVID19derstandard.at/story/20001239…
FROZEN FOODS—"We know that the virus can persist & survive in conditions that are found in these cold and frozen environments.” More work needs to be done to understand "the possible role of the cold chain, frozen products in the introduction of the virus”, says WHO Peter Embarek
2) Previously, frozen seafood exposure was shown it could possibly lead to infection. #COVID19
WORLD’s SECOND SINGLE DOSE #COVID19 vaccine—an Ad5-nCoV vaccine by CanSino, showed 91% efficacy rate in preventing severe disease, & effective to prevent 65.7% of symptomatic diseases in P3 trial. Comparable to J&J’s 66% efficacy, with no freezing needed. bloomberg.com/news/articles/…
2) single-shot vaccines offer some advantages over the cutting-edge mRNA inoculations from Pfizer and Moderna. The mRNA two-dose shots require deep-freeze storage and risk spoiling if thawed too quickly. CanSino and J&J’s candidates are easier to store...
3) and don’t require people to return at a set time for the second jab -- something that’s hard to guarantee especially in developing countries. “The single-shot is an important factor—when you ask people to show up for a 2nd shot 3 weeks later, people will forget or not care.”
OUTBREAK OF #B1351 VARIANT IN AUSTRIA 🇦🇹—B1351 🇿🇦 variant now identified in 293 cases in western Austria state of Tyrol—at least 140 active cases. Germany🇩🇪 is considering closing the border to Tyrol. Austria govt has issued urgent travel warning. #COVID19 tagesschau.de/ausland/europa…
2) “Experts rated the South African mutation as more dangerous than the British one. "The course of the disease should be more severe and the resilience to vaccinations should be higher. This mutation would set us back a long way."
3) Folks, Tyrol is a very popular Alpine tourism region of Austria that is bordered by Germany 🇩🇪 to the north, Switzerland 🇨🇭& Liechtenstein 🇱🇮 to the west, and Italy 🇮🇹 to the immediate south. If it’s in Tyrol, it’s likely all over Central Europe. And that what is worrisome.
Immunocompromised 45 year old suffered from #COVID19 for 155 days before he died. The virus was changing very quickly inside the man's body—it acquired a big cluster of >20 mutations—resembled the same ones seen in #B117 & #B1351. (NPR audio Part 1 of 2)🧵 npr.org/sections/goats…
2) NPR report audio part 2 of 2:
Dr. Li couldn't believe what they found. "I was shocked," he says. "When I saw the virus sequences, I knew that we were dealing with something completely different and potentially very important."
3) “Toward the very end of his life, he was treated with monoclonal antibodies, from Regeneron," Li says. "And shortly thereafter, we saw evidence that suggested the virus was developing resistance or escaping from these antibodies as well."
DIFFERENCE A VARIANT CAN MAKE: Early in the Oxford-AstraZeneca’s South Africa 🇿🇦 trial, before #B1351 variant became dominant, the AZ vaccine had a great efficacy of 75% risk reduction of #COVID19 after a single dose! But all that disappeared once B1351 variant showed up... 🧵
2) Notably, #B1351 variant showed up midway through the trial and soon became the dominant strain after early November. And because it had the worrisome E484K “Eeek” mutation that could evade neutralizing antibodies, it then completely flipped the AZ vaccine results...
3) Notably, notice how the early 75% early efficacy seen by the vaccine completely got flipped around and was no longer any better late in the trial! Resulting in a crap 22% non-significant efficacy.
Late trial, 95% of infections sequences were #B1351 according to other data.