Kerala - Of delayed peak and long plateau: After reporting the 1st Covid19 case in Jan 2020, KL hit it's peak only in Oct 2020. Even till Sept., cases per million of KL remained lower than that of states like TN, KA, AP.
The story after the peak though has been different.

1/4
TN + AP peaked in Aug '20, while KA hit it's peak in Sep '20. KL had a monthly TPR of only 5.8% in September (overall TPR 4.5%), again indicating an increasing but controlled spread.
Did this relatively controlled spread for most of 2020, lead to increased cases post Sept.?

2/4
After hitting the peak, states like TN, KA and AP saw a significant decline in cases within 2 months. Unlike them, monthly cases per million and TPR have mostly plateaued in KL, without seeing a significant dip.
A combination of increased mobility, high population density,

3/4
....a higher uninfected % of population due to initial controlled spread and testing growth rate lagging case growth rate, could have contributed to the peculiar case trend in KL.
Over the last 4 days, we have seen a drop in daily TPR in KL and hope that the trend continues.

4/4

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More from @covid19indiaorg

5 Jan
The expert committee of CDSCO met on 30/12, 01/01 and 02/01 to deliberate on accelerated approval of vaccines. Recommendations made on each day have been officially published.

📣 In this thread, we take a look at the timeline of events that lead to the approval. Must read.

1/n
30th December:
#Covaxin: Bharat Biotech presents status of Phase 3 trials and updated safety data.
📣 Committee recommends that updated safety and EFFICACY data of Phase 3 trials have to be presented for further consideration.

2/n
30th December:
#Covishield: SII presents safety and efficacy data of Phase 2/3 trials from UK, Brazil, SA along with data from ongoing Indian trials. SII mentions that UK has provided EUA.

📣 Committee asks for complete details of UK approval to be submitted.

3/n
Read 10 tweets
5 Jan
Israel's vaccination sprint: Around 14% of Israel's total population have already received the 1st dose of Covid19 vaccine. A sprint that has taken Israel to the top of the per capita vaccination chart.

How did the country of 9M people achieve this? A thread.

1/n
Small size: Israel is a small country of 9 million people - slightly larger than Chennai and less than half of Mumbai's population. The size makes distribution/logistics easier and can't be compared to the challenges of larger countries. But, the story goes beyond it's size.

2/n
Healthcare system: At the center of Israel's swift vaccination progress is the universal, vertically integrated, digitised healthcare system. Health care is a fundamental right in Israel, with mandatory health insurance run by 4 health maintenance organizations.

3/n
Read 12 tweets
4 Jan
A (long) thread on Bharat Biotech - ICMR's #Covaxin vaccine.

1. Type of vaccine: #Covaxin is a whole virion INACTIVATED vaccine.
In such vaccines, the whole #sarscov2 virus is inactivated to make it harmless and used to make the vaccine. Seed virus provided by NIV Pune.

1/n Image
2. How is it different from #Covishield? Covishield is a VIRAL VECTOR vaccine. Here, the spike protein of #sarscov2 is sequenced. A weakened virus that causes common cold in chimpanzees called Adenovirus is used as the vector to carry the spike protein in the vaccine.

2/n Image
3. Phase 1 trial: 375 persons in trial, done across 11 sites in 9 states.
Age profile: 18 to 55.
375 persons divided into 4 groups. 3 groups of 100 each received 3 different formulations of the vaccine and 1 control group of 75 received placebo.
Dosage: 2 doses, 14 days.

3/n Image
Read 12 tweets
26 Dec 20
Before we sign off from 2020, take few minutes and let us know how the year was for you.
Your experiences of a truly unique year, deserves to be documented!

1. Do you think 2020 was a good year for you personally.

1/9
2. How did the pandemic affect your personal relationships after March 2020?

2/9
3. How did the pandemic affect your professional/student life?

3/9
Read 9 tweets
22 Dec 20
#sarscov2mutation What does it mean for us?
Mutation of viruses is part of it's evolutionary process. Once inside the host, viruses start replicating. Errors during this replication process results in changes to the genetic makeup of the virus - leading to mutations.

1/9
Depending on where in the genome the changes happen, mutation can impact the survivability of the virus. #SARSCoV2 is an RNA virus (like dengue) and is prone to more mutations than a DNA virus (eg. smallpox).
📣 As of Sept. abt. 12k mutations of #SARSCoV2 were documented.

2/9
What about the new strain reported in UK? Named "VUI-202012/01" (Variant Under Investigation in Dec 2020), it has a set of 23 mutations (out of close to 30k genetic letters). Most notable being the change in spike protein that is used by the virus to bind to our host cells.

3/9
Read 9 tweets
21 Dec 20
As the year draws to a close, this thread looks at the progression of multiple Covid19 parameters across states/UTs of India:

✅ Take a look at this thread depicting progression of Confirmed cases, Tests, Tests Per Million and Case Fatality Rate across states/UTs in 2020.

1/5
Progression of total number of tests done by states/UTs from April to 19th December, 2020.

2/5
Timeline of Case Fatality Rate across states/UTs from April to 19th December, 2020.

3/5
Read 5 tweets

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