Discover and read the best of Twitter Threads about #Covaxin

Most recents (24)

The #WHO on April 2 issued a statement saying the supply of #Covaxin to UN agencies had been suspended due to "deficiencies in good manufacturing practices". There were not mny details. In an email, they have now told @TheWireScience the following : science.thewire.in/health/who-cov… (1/n)
"Problems were detected in some parts of the manufacturing process. SOME CHANGES WERE MADE after the emergency-use license was granted but were not submitted to the national drug regulator and WHO for evaluation and validation."
The WHO still didn't specify what were those changes. Whether those changes were related to increase the yield, or on the front of raw materials or due to some other reason--we don't know. A GMP expert said major changes, if done post approval, have to be informed.
Read 10 tweets
Join our webinar on #COVID19 #Vaccination & Adolescents, today

Speakers:

Senior Advisor to Govt. of Maharashtra and @UNICEF on Child Health, Dr. Mrudula Phadke

&

Prof. Praveen Kumar
Lady Hardinge Medical College, Delhi,

Live From ⏰ 11 AM

🎥
📡Live Now📡

Webinar on #COVID19 #Vaccination & Adolescents

Speakers:

Senior Advisor to Govt. of Maharashtra and @UNICEF on Child Health, Dr. Mrudula Phadke

&

Prof. Praveen Kumar
Lady Hardinge Medical College, Delhi,

Join live 🎥
Govt. is doing its best to provide right information about #COVID19 #Pandemic to public

The purpose of this webinar on 'COVID-19 Vaccination & Adolescents' is to address the concerns of parents regarding ongoing #Vaccination for adolescents:

- ADG @PIBMumbai
Read 18 tweets
[BREAKING] In a 100 CRORE defamation case filed by BHARAT BIOTECH, Andhra Court ordered taking down of 14 articles on @thewire_in and restrained

1)THE WIRE
2) Siddharth Vardarajan
3) SR Bhatia
4) M.K. Venu &others

From publishing DEFAMATORY articles relating to @BharatBiotech
Bharat Biotech represented by Senior Advocate Vivek Reddy argued that The Wire had published articles which contained false allegations against Bharat Biotech and COVAXIN with a MALICIOUS intent to undermine the reputation of Bharat Biotech. @BharatBiotech @kvivekreddy #COVAXIN
Bharat Biotech had sued the following defendants
Read 4 tweets
The story of #Mild #Omicron Part 1
Long Thread -Story of 8 countries
Italy- Deaths due to Omicron have been higher than Delta by miles and almost reaching prevaccination levels .Vaccines were released around end December- Early January in most countries #OmicronIsNotMild ctd)
Ctd2)Denmark is second country- Again the Delta was decimated by the vaccines BUT with the Omicron the deaths have reached almost pre vaccine deaths #OmicronIsNotMild, #Omicron, #OmicronVariant , Also the Danes like others opened up after reaching good vaccination levels .
Ctd3) Country 3- Canada -Here too #Omicron crossed the deaths due to Delta by miles , reaching number of deaths before vaccination, in fact overshooting that number
#OmicronIsNotMild , needless to say the Canadians are fed up because it is #Mild in the media
Read 12 tweets
1.5 month old baby of a breastfeeding mother died on 6-Dec-2021. Puja Devi took #COVAXIN earlier that day at a vaccination camp. 3 hours later, the mother breastfed milk to her child, but the baby suddenly died on the same night.
24 y/o pregnant woman Rinki Rajak & her 8 month old unborn baby died on Wednesday, October 13, 2021, less than 2 weeks after receiving COVID-19 vaccine. She was forcefully vaccinated by a nurse at the local hospital on Sept 30th, despite her refusal.
naidunia.com/lite/madhya-pr…
A 7-month old baby died due to premature delivery of mother Rinku Kushwaha (28), resident of Ajaypur village, due to severe fever a day after receiving first dose of COVID-19 vaccine.
naidunia.com/madhya-pradesh…
Read 5 tweets
How To Register Online, The Adverse Event For Children Receiving COVAXIN?

Children in 15 -18 age-group are being given #COVAXIN as the Covid-19 Vaccine. Many children are facing severe #AdverseReactions or even death after taking #COVAXIN .
For complaints about #COVAXIN to the manufacturer, on receiving any #AdverseReactions after vaccination, please email to pvg@bharatbiotech.com for registering AEFI (Adverse Event Following Immunization) #aefi
Call on Toll-free number: 1800 102 2245 if any help needed from Bharat Biotech (manufacturer of COVAXIN) for registering #aefi or making regular follow-up.
Read 5 tweets
Subramanian Swamy as you have said in your interview with @afshinrattansi that and we quote:
"I have no report of any Covaxin death that has been submitted to our committee, if any one can point out to that I would be happy to take it up"
@MoHFW_INDIA @Swamy39
We would like to share some information with you.

As of 31/01/2022 from National #AEFI reports we have collected 5 #deaths under A1 and B1 categories after administration of #Covaxin
@CovaxinBharat
Reason of Reporting :DEATH
68
Male
Date of vax : 15/3/2021
Vax:#Covaxin
Diagnosis: Acute Inferolateral myocardial infarction
Classification: B1
National ID: IND(CO-AEFI)HAFTB21001
Read 13 tweets
💡We need to consider this vaccine—a whole virus traditional one that may add more protection versus variants (watch the🎥 why) & mRNA-vaccine-hesitant folks can be comfortable with. ➡️The FDA should honestly authorize #COVAXIN—EUA app submitted & waiting.
2) Notably, unlike a single target spike protein vaccine line mRNA ones or the adenovirus (J&J and AstraZeneca) ones, an inactivated whole virus traditional vaccine has multiple protein targets for which the body can “learn” to build recognition and immunity if spike is mutated.
3) P.s. I own **zero** stocks in COVAXIN makers. I’ve never traded their stock.
Read 6 tweets
Since you have experienced and accept the incidence of vaccine related complications, we request to further look at our questions and suggestions in the thread below @ManishTewari
@CDSCO_INDIA_INF has not granted permission to conduct clinical trials on pregnant & breast-feeding women. All clinical trials enrolled ONLY healthy participants in the COVID-19 vaccine trials & as per exclusion criteria, pregnant and lactating/breast-feeding women were excluded
#COVAXIN & Sputnik manufacturers clearly mention contraindications for pregnant and breast-feeding women. Also, the Covishield manufacturer mentions that not enough studies have been done on pregnant women. Yet, @MoHFW_INDIA and the Government are recommending these shots ...
Read 15 tweets
🚨🚨🚨
Basti, UP | 7 students faint after their vaccination | rushed by ambulance to PHC | referred to dist hospital as situation is not improving
m.up.punjabkesari.in/uttar-pradesh/…
Chattisgarh, village Lalpur | 12th standard girl died the same evening she was jabbed
Chattisgarh, Rajnandgaon | 17 YO took ill and started vomiting hours after #Covaxin shot | rushed to local PHC and then referred to civil hospital | died on the way
google.com/amp/s/www.naid…
Read 5 tweets
More than 40 lakh teenagers in the 15-18 age group received their first dose of #Covid19 vaccines on Monday. Some concerns were raised about ‘expired’ #Covaxin being administered to this younger group, leading to the Health Ministry issuing a clarification.
The Ministry described these claims as “false and misleading” and said these were based on “incomplete information”. It pointed out that the shelf life of #Covaxin, the only vaccine being given to the people below 18 years of age, had been extended: indianexpress.com/article/india/…
The Health Ministry said the shelf life of #vaccines is extended by the national regulator, Central Drugs Standard Control Organisation, or CDSCO, based on a comprehensive analysis and examination of stability study data furnished by the vaccine manufacturers.
Read 8 tweets
The SmPC (Summary of Product Characteristics) for #Covaxin (see the link to Bharat Biotech's website here: bharatbiotech.com/images/covaxin…
has not been updated since the #EUA was granted for use in the 12-18 year age group. It still says (page 1):
"COVAXIN® is indicated for active immunization against SARS-CoV-2 Virus infection for age ≥18years."

The SmPC is a legal document that is part of the approval process. On the question of expiry date, it says:(page 10),
"6.3 Shelf life
The expiry date of COVAXIN® is indicated on the label and carton of the vaccine. Do not use the
vaccine after the expiration date shown on the label and carton of the vaccine."
Read 5 tweets
India on Monday reported 33,750 fresh #Covid19 cases and 123 deaths. According to the Union Ministry of Health, the #Omicron tally in the country has reached 1,700, of which 639 have recovered or been discharged. Image
Meanwhile, Covid vaccination for teenagers, aged between 15 to 18 years, began today. The Union Health Ministry had announced that Bharat Biotech’s #Covaxin will be the one that will be administered to eligible children — in two doses 28 days apart.

📸Amit Chakravarty Image
A 17-year-old became the first one to get the #COVID19 jab at the PCMC hospital in Pune's Kasarwadi as vaccination of those between 15 to 18 years began at 10.20 am.
Live updates: bit.ly/3eHP1rN

📸Express photo Image
Read 12 tweets
The approvals, the authorisations, the announcements go hand in hand. Now the #Covaxin bhakts will line up to get their children p0!s0ned. ImageImage
I am sensing the 15-18 age range to change soon to 12-18. 12-15 applicable to children with comorbidities...😥
Maharashtra is perhaps receiving special incentives ??? Image
Read 10 tweets
💡[Whisper]… there is actually a proven vaccine for kids age 2-4 that is *CURRENTLY UNDER REVIEW* at the @US_FDA with an EUA app submitted on November 5th—but FDA has not moved yet on approval meeting. ➡️Why is the media not talking about this? #COVAXIN ir.ocugen.com/news-releases/…
2) COVAXIN™ (BBV152) is a whole-virion, inactivated vaccine, manufactured using a Vero Cell manufacturing platform, as has been used in the production of the inactivated polio vaccine for the past 35 years, as well as of other traditional childhood vaccines.
3) The submission is based on results of a Phase 2/3 pediatric clinical trial conducted by Bharat Biotech in India with 526 children 2-18 years of age, which bridged immunogenicity data to a large, Phase 3 safety and efficacy clinical trial in nearly 25,800 adults in India.
Read 8 tweets
🆕 WHO has granted emergency use listing (EUL) to #COVAXIN® (developed by Bharat Biotech), adding to a growing portfolio of vaccines validated by WHO for the prevention of #COVID19.
The Technical Advisory Group, convened by WHO and made up of regulatory experts from around the world, has determined that the #Covaxin vaccine meets WHO standards for protection against #COVID19, that the benefit of the vaccine far outweighs risks & the vaccine can be used 🌍.
#Covaxin vaccine was also reviewed by WHO’s Strategic Advisory Group of Experts on Immunization (SAGE), and recommended use of this vaccine in two doses, with a dose interval of four weeks, in all age groups 18 and above. #COVID19
Read 9 tweets
Bharat Biotech's Covaxin gets WHO approval for Emergency Use Listing (EUL) Image
Technical Advisory Group, convened by WHO & made up of regulatory experts from around the world, has determined that #Covaxin vaccine meets WHO standards for protection against COVID, that benefit of the vaccine far outweighs risks & the vaccine can be used across the world: WHO Image
Covaxin vaccine was also reviewed by WHO’s Strategic Advisory Group of Experts on Immunization (SAGE), and recommended use of this vaccine in two doses, with a dose interval of four weeks, in all age groups 18 and above: WHO
Read 4 tweets
Will the newly identified sub-lineages of #Delta may initiate a new wave of #Covid19 in India? What impact the increasing prevalence of the Delta-D clade would have on global #COVID burden?

My write-up deliberating on these issues in @TheWireScience 👇 science.thewire.in/the-sciences/a…
#Delta variant and its extended family: How much do we need to worry?

During the first few months of the #pandemic, the evolution of the virus was relatively predictable, with substitutions accumulating at a fixed pace: 1 substitution every second week 2/
In contrast, the 2nd year of the #pandemic is punctuated by the emergence of several #variants that bore evidence of dramatic evolution 3/
Read 40 tweets
The new #MayoClinic study finds Vaccine Effectiveness (VE) of #Pfizer shot dropped to 42% against #Delta #SARSCoV2 infection (not against hospitalization & deaths). 1/

medrxiv.org/content/10.110… Image
Earlier unpublished reports from #Israel also indicated the same 2/ ImageImage
Few other recent studies have also placed the #VE of Pfizer mRNA vaccine between 40-60% against #SARSCoV2 infection/symptomatic disease but not against severe disease & deaths. Table by @EricTopol 3/ Image
Read 7 tweets
#BombayHC bench of Chief Justice Dipankar Datta and Justice Girish Kulkarni to hear petition filed by adv @DhrutiMKapadia seeking door-to-door vaccination for elderly and bedridden citizens in the state. @CMOMaharashtra was asked to submit guidelines today.
@DhrutiMKapadia appearing in person.
Advocate General Ashutosh Kumbhakoni for the state.
Additional Solicitor General Anil Singh for Union govt.

Kapadia: Policy is given to me last night. It isn't useful. It looks like the Union's "Near the Home" policy.

#BombayHC
Kapadia: When all states can smoothly conduct this drive why are we struggling in #Maharashtra ?

#ThirdWave of #Covid is yet to arrive yet they are not coming up with a proper policy.

Reads out from the state's policy - It says "May be implemented."

#VaccineForAll #BombayHC
Read 15 tweets
Just got to read through the pre-print of COVAXIN phase 3 trial. Yes, it's reassuring that the efficacy against symptomatic COVID-19 is 77.8% and over 65% Delta variant. But, as a reader, I always wish to review through the methodology before interpreting the results (1/n)
Authors have defined symptomatic COVID-19 case as presence of at least two of the selected symptoms. It was not clear from the article whether an individual with only one symptom and tested positive was included in the analysis. Also, no definition given for severe COVID-19 (2/n)
It was not clear why only one Nasopharyngeal swab was taken among symptomatic individuals. Will both of these affect study result? It may affect. The study reports higher CT value in vaccine group. In that case, there may be lesser chance of detecting the virus among (3/n)
Read 10 tweets
1/n
#COVAXIN trial preprint was published few hours ago. Here is my summary of the trial- over 7 slides.

How was the trial designed?
2/n
What was the primary and secondary outcome?
3/n
Was #COVAXIN effective? (1)
Read 7 tweets
COVAXIN Phase 3 Data Analysis ! 💉🇮🇳 -

Efficacy, safety, and lot to lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): a double-blind, randomised, controlled phase 3 trial
medrxiv.org/content/10.110…
Between November 16, 2020 and January 7, 2021 we recruited 25,798 participants who were
49 randomised to BBV152 or placebo groups; 24,419 received two doses of BBV152 (n =
50 12,221) or placebo (n = 12,198).
📍130 cases of symptomatic
COVID-19 were reported in 16,973 (0·77%) participants with follow-up at least two weeks after the second vaccination;

📍24 occurred in the vaccine group and 106 in placebo recipients giving an overall vaccine efficacy of 77·8% (95% CI: 65·2–86·4).
Read 26 tweets
🧵@OmarAzizSenador, @randolfeap e @renildo, irmão de @renancalheiros, apresentaram emendas à MP das vacinas que facilitaram importar a #Covaxin?

⚠️Aziz e Renildo apresentaram emenda para incluir o órgão regulatório indiano. Mas Randolfe, relator da medida no Senado, não #AFP
@OmarAzizSenador @randolfeap @renildo @renancalheiros ➕A MP nº 1.026 de 2021, apresentada pelo @govbr previa em seu art. 16 a possibilidade de a @anvisa_oficial autorizar a importação de vacinas e outros itens sem registros para uso, desde que aprovados pelas agências dos 🇺🇸, 🇪🇺, 🇯🇵, 🇨🇳 e 🇬🇧 #AFP

➡️u.afp.com/U6hA
@OmarAzizSenador @randolfeap @renildo @renancalheiros @govbr @anvisa_oficial ➕Na @camaradeputados e no @SenadoFederal, parlamentares apresentaram emendas para incluir outras agências, dentre elas a da 🇮🇳, o que facilitaria a importação da #Covaxin, mas isso não os vincula à investigação relacionada à importação dessa vacina #AFP
Read 6 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!