“False sense of security”—high tech gathering of 49 tech thinkers was held in 4 day “bubble” without mask mandate after arrival+daily testing. Result? ~43% (21 of 49) of tech attendees got #COVID19 soon after, including organizer @PeterDiamandis. 0% of masked support staff. 🧵
2) They were incredibly careful, including doing 452+ total tests (both PCR and rapid antigen), and excluding the 1 person who tested positive initially upon arrival and didn’t attend. Daily tests thereafter. But no distancing or masks after.
diamandis.com/blog/false-sen…
3) Dr @PeterDiamandis (an MD PhD innovator whom I’ve respected for years) expressed regret..

“I am sincerely and deeply sorry for the consequences of the choices we made. As scientist, engineer & medical person, I believed we were using the very best that science had to offer.”
4) “And I trusted that an immunity bubble was a “real thing”.
I no longer believe that.
In fact, further investigation into testing has revealed even more curious and concerning data. Once it was clear that I personally had contracted COVID-19”
5) “I tested myself with Rapid PCR and Rapid Antigen every day, twice per day, for several consecutive days. I was flabbergasted that NONE of the tests turned up positive. I was consistently negative.
6) “Four days into my quarantine, I finally tested positive on a PCR “Spit Test” that measures viral load. I was told I was “highly infectious."”
7) “So, now, as we send our kids back to school with “routine PCR” testing to keep them safe, as we lower our masks in a friend group bubble saying, “I tested negative yesterday,” as we subconsciously trade vigilance for confidence post PCR testing, do you still believe it?
8) “I thought five physicians and 452 tests and my entire safety team could maintain safety. I was wrong.
What’s more, new and virulent strains are emerging, and there are only three options… masks, vaccines and physical distance. I hope others can learn from my mistakes.”
9) this epidemiologist THANKS you for the excellent documentation @PeterDiamandis. CDC would be proud. And thank you for the honestly and transparency. And thanks for donating to the Frontline Families Fund to support HCW families. I hope your story will save more lives.
10) Thinking over this bubble story more:

📌 Testing did exclude one arrival detected case. So the outbreak could have been worse without arrival testing.

📌They should have also added a precautionary quarantine period of at least 7 days before the “bubble” was formed.
11) But I personally think a precautionary period or 14 days is better. We know incubation has a long tail, and though 14 days isn’t perfect, it should be sufficient in most cases. And that’s what Australia does for all Australian 🎾 Open attendees.
12) The warning sign was that 1st staffer who got COVID tested positive 2 days after the 4 day conf ended, which meant infectious during conference.

So **daily testing** during an initial quarantine period would have found this hidden cases that was likely the culprit.
13) Same thing happened in the WH outbreak. They should have used a multilayered castle defense of masks + ventilation + HEPA filters instead of relying on a single wall of testing, which is important but not enough because of the pre/asymptotical window.
14) and during this infected-but-no-symptom window, we know cases are hard to pick up. We know this from testing performance analysis — it’s not that test is bad — it’s TIMING — too early and early viral load buildup just harder to pickup before symptoms onset (if any at all)
15) I want to emphasize ventilation + air disinfection a bit. Even with masks, air flow and air exchange for fresh / disinfected air is critical. This should be a corner stone of public health during a pandemic of an airborne virus.
16) But this ventilation / air cleaning emphasis has been mostly missing from the latest CDC school reopening guidelines.
17) And the other issue is that often because many people don’t mask or don’t mask properly, we need to double mask or switch to premium masks.
18) KEY DETAIL—While both people wearing masks is best, if only one person out of 2 wears a mask, the double mask (of surgical plus cloth) seems superior to single surgical that is knotted & tucked.
19) Key point #2: Source masking alone >> receiver loose masking alone. This is critical detail.

In fact, a poorly worn receiver-only worn mask has little to no benefits above no masks. Thus, if others are not masked you MUST wear mask properly or DOUBLE UP damnit.
20) the latest CDC school guidelines separate recommendations for schools that do “expanded screening testing” versus those schools that do not.

Shockingly, they allow indoor sports as long as 6 feet in moderate transmission areas. And no ventilation requirements.
21) The CDC also still allows indoor sports in areas with moderate transmission area even WITHOUT any testing. And again no mention of ventilation or air cleaning requirements either for such indoor sports.

Ummm, airborne virus anyone?!?!
22) That said, REPEATED population wide testing does work it done for public health screening repeatedly to slow the virus. Here is why... see thread 🧵 below...

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More from @DrEricDing

16 Feb
Outbreak of #B1351 variant in Ontario 🇨🇦 condominium high rise—5 cases out of 1,800 total residents and staff. Entire building to be tested “voluntarily” for the reinfection-prone evasive variant from South Africa 🇿🇦. #COVID19 cbc.ca/news/canada/to… Image
2) This #B1351 variant is the one WHO warned about last week for reinfection risk.
3) This is the variant in which prior infection had no protection against, not even severe disease in recently placebo group or Novavax trial.
Read 6 tweets
15 Feb
This is a “snownado”.

This is in Texas—where it’s getting dumped with another snow storms, with frigid temps that it’s causing rolling blackouts because gas pipelines have frozen up & people left freezing in homes.

Welcome to 2021 climate change.

2) Key word: polar vortex. It’s caused by weak jet stream caused by climate change.
3) When then allows some places to get much colder while other places much hotter. Overall, it’s net hotter this winter. Image
Read 7 tweets
15 Feb
Up to 70% deadlier—UK 🇬🇧 govt advisors now says the #B117 variant might be 30-70% more severe/deadlier than old strains.

The lower female risk also eroding—hospitalization now ~50:50 male-to-female ratio (compared to more men during 1st wave).🧵
#COVID19 aljazeera.com/news/2021/2/15… Image
2) The results of the group’s analysis are worrisome, said David Strain.
“The higher transmissibility means that people who were previously at low risk of catching COVID (particularly younger fitter females) are now catching it and ending up in hospital,″ Strain said.
3) Earlier last month it was speculated to be just 30-40% more severe & deadly. Now they have upgraded it.
Read 5 tweets
15 Feb
📍FREE RAPID ANTIGEN TESTS FOR ALL IN AUSTRIA—*5 free rapid antigen home tests per month* starting March 1st for every person—pickup in pharmacies. Austria 🇦🇹 #COVID19 positivity has doubled from 3.1% to 6.4% in 4 days, along with worrisome #B1351 surge.🧵
derstandard.at/story/20001241… Image
2) there are some variation by week, but this is a noted increase says @dberghofer.

Day / tests / positive /%

Thu / 50.444 / 1.577 / 3.1
Fr / 46.981 / 1.731 / 3.7
Sa / 34.958 / 1.433 / 4.1
Sun / 24.791 / 1.184 / 4.8
Mon / 19.179 / 1.225 / 6.4
3) There are many kinds of #COVID19 testing strategies. But a population wide public health screening and weekly screening that Austria 🇦🇹 is doing, even if imperfect sensitivity, is meant to “rake” out most infectious cases, says @michaelmina_lab. So this is good move. Image
Read 4 tweets
15 Feb
CANARY IN THE COAL MINE FOR SCHOOLS: What’s going on here—a tech savvy dad strapped a CO2 monitor to his kid to check air CO2 exposure on a school trip. Crazy high CO2 indicates poor indoor ventilation.

Ventilation & air disinfection will prevent outbreaks. #COVID19 #Ventilate
2) VENTILATION is key. Both ventilation and masks needed to reduce risk indoors. But most buildings not ventilated well enough.

3) we need to disperse aerosols quickly. Key is ventilation. 🇯🇵 assumed it was airborne from the beginning. Here is how to ventilate your school classrooms if unable to open windows. #COVID19
Read 4 tweets
15 Feb
📍“There’s clearly something going on with this mutation”: 7 striking new converging variants with same #677 mutations suddenly found. Experts across US independently found them & are worried—all 7 changed same spike protein amino acid—bad sign.🧵 #COVID19 nytimes.com/2021/02/14/hea… Image
2) It’s been circulating for a few months, but because of poor genomic surveillance in the US, it took a while to realize it’s becoming a problem and growing across the US. We barely do 1% sequencing in the US. medrxiv.org/content/10.110… Image
3) Q677H & Q677P as a group change the same Q (glutamine) amino acid inside the spike protein. All 7 mutations yield the same change replacing the glutamine. Convergent evolution usually always means it’s something advantageous to the organism’s survival. That’s usually bad sign.
Read 16 tweets

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