NIAID investigators and collaborators at @ImmunoScape and @JHUcovidplasma recently published a study in @jclinicalinvest characterizing #Tcell responses in people who recover from #SARSCoV2 infection. jci.org/articles/view/…
T cells are a type of white blood cell part of the immune system & may allow for long-term protection against #SARSCoV2. Learning more about natural infection can help guide development of improved treatments and vaccines.
The researchers found that the majority of CD8+ T cells targeted internal and non-structural sites on viral proteins (epitopes), indicating possible targets for next-generation vaccines.
The team built on this research by examining SARS-CoV-2 variants #B117 #B1351 #B11248 for overlap with the identified epitopes from the prior study & found that virtually all CD8+ T-cell responses should recognize the variants, which should partly mediate protection from disease.
The new findings have yet to be peer-reviewed but are available online as a pre-print medrxiv.org/content/10.110…
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