'COVID-19 Vaccine AstraZeneca is indicated for active immunisation of individuals ≥18 years old for the prevention of (COVID-19).

Efficacy and safety data are currently** limited in individuals ≥65 years of age.** (see sections 4.8 and 5.1)' gov.uk/government/pub…
Paediatric population
The safety and efficacy of COVID-19 Vaccine AstraZeneca in children and adolescents (aged <18 years old) **have not yet been established. No data are available.**
Immunocompromised individuals
It is not known whether individuals with impaired immune responsiveness, including individuals receiving immunosuppressant therapy, will elicit the same response as immunocompetent individuals to the vaccine regimen.
Duration and level of protection
The duration of protection has not yet been established. As with any vaccine, vaccination with COVID-19 Vaccine AstraZeneca may not protect all vaccine recipients.
4.5 Interaction with other medicinal products and other forms of interaction
**No interaction studies have been performed.**

Concomitant administration of COVID-19Vaccine AstraZeneca with other vaccines has not been studied (see section 5.1).
4.6 Fertility, pregnancy and lactation
There is a limited experience with the use of COVID-19 Vaccine AstraZeneca in pregnant women.
Preliminary animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryofetal development, parturition or post natal development; definitive animal studies have not been completed yet.
The full relevance of animal studies to human risk with vaccines for COVID-19 **remains to be established.**

Administration of #COVID-19 Vaccine #AstraZeneca in pregnancy should only be considered when the potential benefits outweigh any potential risks for the mother and fetus.
It is unknown whether COVID-19 Vaccine AstraZeneca is excreted in human milk.

''Preliminary animal studies'' do not indicate direct or indirect harmful effects with respect to fertility.
Summary of the safety profile
The overall safety of COVID-19 Vaccine AstraZeneca is based on an ''interim analysis'' of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa.
At the time of analysis, 23,745 participants ≥18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. Out of these, 12,021 received at least one dose of COVID-19 Vaccine AstraZeneca.
The median duration of follow-up in the COVID-19 Vaccine AstraZeneca group was 105 days post dose 1, and 62 days post dose 2.

Demographic characteristics were generally similar among participants who received COVID-19 Vaccine AstraZeneca and those who received control. Overall,
among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male.

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More from @DebraClaridge

21 Feb
Dr Edmunds told #Marr. 'The *vaccine doesn't give a 100% protection'.* 'The vast majority of us are still yet to be vaccinated *or indeed yet to be *infected* um...& you know hopefully we go through the route of vaccinating individuals'. So Edmunds admits hardly anyone infected!
''The vast majority are yet to be infected''. Even in a 'pandemic' with what they claim is a very virulent virus? Our immunes systems are clearly working!
Read 9 tweets
15 Dec 20
#BBCPanorama 'Prof Sarah Gilbert of Vaccinology, Oxford Uni. 'There is an anti-vaccine movement- what we wld like to do is to help people to try to understand, how the vaccine works. How much work has gone into producing it. ImageImage
'What we need to do to get a vaccine to protect people against this 'terrible disease''.

A virus actually dear prof that is a minor illness in the majority - the majority whom do not need to be vaccinated.
I am always interested when vitally important information is omitted such as this. #Panorama stated that one of the volunteers had neurological issues, but then did not reveal what those issues were??🤔
Read 8 tweets

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