Indiana University Infectious Diseases Fellowship
21 Feb,
11 tweets, 5 min read
#idboardreview 16 M fever, progressive neck swelling (bull neck), nasal regurgitation of food, progressive dyspnea, orthopnea. Pharynx/tonsil w/ gray membrane. EKG with heart block. Diagnosis? #medEd #idmedEd #idtwitter 
#corynebacterium #diphtheriae gram positive bacillus produces epidemic Upper respiratoryinfection in unimmunized individuals
#diphtheria spreads by air & direct contact. Asymptomatic carriage important in transmission. Rare now due to vaccination
#corynebacterium #diphtheriae non-sporulated, uncapsulated and non-motile. Brown colonies & halos on tellurite medium & requires lysogenic beta phage to produce toxin responsible for dz.
#diphtheria subacute: low grade fever, hoarseness, pain, necrotic pseudo membrane that extends to larynx & can cause strife & fatal obstruction. Toxin can cause fatal carditis & motor neuropathy. Cutaneous infection can cause indolent ulcer
#diptheria dx clinical pseudo membranes, palatal paralysis, unimmunized, endemic area. Colonies on Tellurite and pcr w/toxin gene
#diphtheria tx antitoxin plus penicillin
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