Thread by @sailorrooscout

The FDA Vaccines and Related Biological Products Advisory Committee briefing document on Johnson & Johnson’s COVID vaccine has been posted and their efficacy data looks extremely promising. It appears to elicit robust efficacy against all variants including B.1.351!

It also demonstrates its ability to elicit strong cell-mediated immunity via T-cell responses with protection rising over time. This is the first one-dose vaccine that could do a lot of wonders right now. EUA is expected this week.
Document is here:
fda.gov/advisory-commi…

The efficacy of the Johnson & Johnson vaccine against moderate to severe/critical COVID-19 across all geographic areas was 66.9% at least 14 days after the single dose vaccination and 66.1% at least 28 days after vaccination. In addition, there were no specific safety concerns

identified in subgroup analyses by age, race, ethnicity, medical comorbidities, or prior SARS-CoV-2 infection.

If you are interested in more on this vaccine please see:

https://twitter.com/sailorrooscout/status/1354107883345092611

For those of you in the UK, 30 million doses have been ordered but I don’t believe there is an expected delivery just yet as the approval is pending.

Highlights: One-dose. Easy storage requirements. 28 days post-vaccination the vaccinated group had ZERO cases requiring medical intervention, ZERO hospitalizations and ZERO deaths. These were real-world results outside of the lab by the way. Effective across all demographics.

For those asking, there was a 74% reduction in asymptomatic infection in a small number of cases. I think we need to ramp up production and distribution of this vaccine across the globe, especially to lower income countries. This vaccine is nothing short of a game changer!

Lastly to clarify, Johnson & Johnson specified one dose showed 86% efficacy against severe forms of COVID-19 in the United States, and 82% against severe disease in South Africa. Vaccine efficacy was also not affected by P.1 in Brazil.
nytimes.com/2021/02/24/sci…

This is even better news than I had initially thought. Looks like we could have 700M doses by July.
medpagetoday.com/infectiousdise…

So the above article is applying to supply of all vaccines as a whole (not just J&J hence that high number). The U.S. is prepared to send out 3-to-4 million doses of J&J’s COVID vaccine as early as next week should the FDA grant emergency use authorization this Friday I read.