1/ #IVM #Ivermectin "studies found that ivermectin could inhibit replication of SARS-CoV-2 in monkey kidney cell culture with an IC50 of 2.2–2.8 μM.[58][59] Based on this information, however, doses much higher than the maximum approved or safely achievable for use in humans ."
2/ "..would be required for an antiviral effect... such high doses are not covered by current human-use approvals of the drug and would be toxic,..the antiviral mechanism of action is considered to operate via the suppression of a host cellular process,[60] .."
3/ #IVM "specifically the inhibition of nuclear transport by importin α/β1.[61]" #IVM in high dose is toxic since it "may interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA)." cell.com/trends/parasit…
4/ "#Ivermectin stimulates excessive release of neurotransmitters in the peripheral nervous system of parasites. It is thought to work by paralysing the parasite or inactivating the parasite gut. In humans the neurotransmitters acted on by ivermectin are in the brain." 
5/ #GABA "enhanced the catabolism of serotonin into N-acetylserotonin (the precursor of melatonin) in rats.[56] It is thus suspected that GABA is involved in the synthesis of melatonin and thus might exert regulatory effects on sleep and reproductive functions.[57]"
6/ #GABA has effects on the production of growth hormone "It is suspected that GABA is involved in the synthesis of melatonin and thus might exert regulatory effects on sleep and reproductive functions." en.wikipedia.org/wiki/Gamma-Ami…
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