Indiana University Infectious Diseases Fellowship
9 Mar,
8 tweets, 3 min read
immune reconstitution inflammatory syndrome #IRIS exaggerated atypical inflammatory response following initiation of ART either paradoxical worsening or unmasking of a infection
#IRIS memory T cells are redistributed from lymphoid tissue to organs, and the number of CD4+ and CD8+ T cells increases faster than that of regulatory T cells, resulting in an imbalance in the immune system
#Histoplasmosis-associated #IRIS rare with an estimated incidence rate of 0.74 cases per 1000 HIV-infected person-years and may present months after initiation of ART
#Histoplasmosis #IRIS is classically characterized by fever, fatigue, and a combination of respiratory and/or gastrointestinal symptoms. CNS and cutaneous involvement appear to be far less commonly reported
Cutaneous manifestations of #Histoplasma are most often described as diffuse papuloulcerative lesions with crusting, followed by pustular or nodular lesions
Treatment continue ART, amphotericin initially followed by itraconazole
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