Thanks to @Anna_Rothschild and @FiveThirtyEight for having me on PODCAST-19 to discuss the future of #COVID19 #vaccines as we enter new phases of this pandemic. What an honor to be joined by @JuliaLMarcus! My main point is that I think there are ... 1/5
fivethirtyeight.com/features/turni…
two types of vaccines. First there are 'pandemic' vaccines, which is what we have now - excellent at preventing hospitalizations and deaths and most useful for decompressing our health care infrastructure and reducing mortality in the most vulnerable. These vaccines will ... 2/5
have the biggest impact on returning to normal, so to speak, where schools, restaurants and workplaces can open up again. The second type of vaccines are 'maintenance' vaccines which are going to come as boosters or 2.0 versions optimized for new variants....3/5
For these vaccines, we are going to ask more from them, and we can start comparing in earnest - which one is better at blocking transmission, or better at blocking mild/mod symptoms, or elicit more durable immunity, or have fewer side effects. These vaccines will keep the ...4/5
pandemic in check and hopefully move us to a model more similar to influenza, where we need to remain vigilant with vaccinations (and equity!) and there are still bad outcomes for some, but the whole of society can still function. 5/5

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More from @k_stephensonMD

17 Nov 20
Hi friends! Today's news about the NIH-Moderna #COVID19 #vaccine is astonishingly good. I've never seen my colleagues - weathered, skeptical professor types - so giddy and delighted and surprised. Here's a thread about what it means (and doesn't): 🧵 1/n
There are caveats and I will get to them (wear a mask!), but for a moment let's look at the amazing numbers they reported: there were 95 cases of COVID-19 so far and *90* of those cases were in the group that got the fake (placebo) group. Only 5 cases were in the vaccine ... 2/14
group. The vaccine also seemed to protect against severe disease. There were 11 cases of severe COVID-19 in the placebo group and 0 cases in the vaccine group. 🤩 Wow!
So now, other things to know: ... 3/14
Read 14 tweets
9 Nov 20
What do you need to know about the #COVID19 #vaccine news today? Here's a quick explainer 🧵. First, this is very, very good news! The first data from the first vaccine tested (Pfizer) is extremely encouraging. There was never a guarantee that any of these vaccines ... 1/8
could actually protect against COVID-19 - it was totally unknown. Now, we know it’s possible.
What else do you need to know?
- This vaccine will not be up for emergency approval until there is 2 months of safety data collected. They should hit that mark after Thanksgiving... 2/8
- All we know so far is that 2 shots of this vaccine will prevent disease in 90% of people vaccinated in the first month or so after vaccination. We do not know anything about whether that protection disappears immediately or is durable or needs to be boosted. ..3/8
Read 8 tweets

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