New pre-print on Paxlovid rebound from our group @BIDMC_CVVRTrial, along with @sabeti_lab, Amy Barczak @ragoninstitute and @mispri2.

We enrolled 36 people with SARS-CoV-2 (11 on Paxlovid) and did PCR every day for 2+ weeks. Here’s what we found… (1/8)
medrxiv.org/content/10.110… One person out of 25 in the untreated group had viral rebound (4%), defined as at least 2 negative PCRs followed by at least 2 positives. 3 people out of 11 who took Paxlovid had rebound (27%). Those that rebounded after Paxlovid looked similar to an acute infection (2/8)

I gave a talk this morning about #Omicron with @PaulSaxMD @SanjatKanjilal & Dr. Ruanne Barnabas. We covered a lot of science but our bottom line was always the same: we need to increase access to diagnostics, treatments & vaccines to truly control COVID-19. 🧵and slides... 1/10 It's only been a year since we rolled out our vaccines, but since then we have administered >10 billion doses and probably prevented >1 million deaths in US alone. But inequity in global vaccination persists. 2/10

Obviously it's good news that J&J vaccine is holding up against delta in data from South Africa. But the only reason we have that data is bc some insanely resourceful scientist heroes in SA scratched out 500K doses from thin air to protect their health care workers when .. there were no COVID-19 vaccines in the entire country. Now we sit back in the US and watch delta surges burn through country after country and just lap up the data to help reassure us about the doses we already got! What's amazing about this study, what we really

We just released data on the durability of immune responses following the J&J #COVID19 #vaccine, including responses against #delta. The paper is in press @NEJM and this is the pre-print. To help explain the data, here’s a 🧵... 1/12 medrxiv.org/content/10.110… Dan Barouch, myself and partners started running a 25 person study @BIDMC_CVVRTrial in July 2020 as part of the phase 1 J&J vaccine program. The study tests 1 dose vs. 2 doses (as well as high doses) against placebo. This study looks at immune responses – not efficacy. 2/12

The recent change in @CDCgov policy regarding masking has prompted a lot of people to ask: do #COVID19 #vaccines block transmission of the virus to others? Here is a 🧵using slides my colleagues and I put together recently. @DrJRMarcelin @ElizabethRBrow2 Slides made by me (Harvard), Audrey Pettifor (UNC), Jasmine Marcelin (UNMC), and Holly Janes and Elizabeth Brown at the Hutch.

Thanks to @Anna_Rothschild and @FiveThirtyEight for having me on PODCAST-19 to discuss the future of #COVID19 #vaccines as we enter new phases of this pandemic. What an honor to be joined by @JuliaLMarcus! My main point is that I think there are ... 1/5
fivethirtyeight.com/features/turni… two types of vaccines. First there are 'pandemic' vaccines, which is what we have now - excellent at preventing hospitalizations and deaths and most useful for decompressing our health care infrastructure and reducing mortality in the most vulnerable. These vaccines will ... 2/5

Hi friends! Today's news about the NIH-Moderna #COVID19 #vaccine is astonishingly good. I've never seen my colleagues - weathered, skeptical professor types - so giddy and delighted and surprised. Here's a thread about what it means (and doesn't): 🧵 1/n There are caveats and I will get to them (wear a mask!), but for a moment let's look at the amazing numbers they reported: there were 95 cases of COVID-19 so far and *90* of those cases were in the group that got the fake (placebo) group. Only 5 cases were in the vaccine ... 2/14

What do you need to know about the #COVID19 #vaccine news today? Here's a quick explainer 🧵. First, this is very, very good news! The first data from the first vaccine tested (Pfizer) is extremely encouraging. There was never a guarantee that any of these vaccines ... 1/8 could actually protect against COVID-19 - it was totally unknown. Now, we know it’s possible.
What else do you need to know?
- This vaccine will not be up for emergency approval until there is 2 months of safety data collected. They should hit that mark after Thanksgiving... 2/8