Most of our 'standard' strategies -- cloth masks, "stay-at-home", distance -- do nothing to address this cycle of transmission
(2/6)
In my community, anecdotally, hospitalizations from this cycle of spread has only declined with rising vaccinations
It should never take waiting for a vaccine - & allowing thousands to suffer & die in the interim - to stop one of the main drivers of this pandemic
(3/6)
We've needed
- #bettermasks (hbr.org/2020/10/essent…)
- better ventilation (see @j_g_allen)
- paid sick leave with job security
- better financial stimulus so those at high-risk of severe Covid could choose not to work (like those well-off can do)
- serial #rapidtesting
(4/6)
This isn't a technical failure or a moral lapse. It is the inevitable outcome of systems premised on inequity where decisions slant in favor of those with $/power
If those with $/power worked in these settings, do you think we would still not have any of these measures?
(5/6)
If we want to control epidemics going forward, it's not just about tactics & technology but also addressing the structural underpinnings of transmission
It shouldn't take a trickle-down vaccine a year later to protect those at greatest risk
(6/6)
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We're deploying vaccines like we do annual flu shots rather than the mass vaccinations done in Africa & Asia where millions are vaccinated in weeks
Years ago, Joe Rhatigan & I studied these campaigns. They offer several lessons that can inform what we need in the US now
THREAD
1/ Be proactive
Instead of passively waiting for people to come get vaccinated, we need to search them out & go to where they are & keep following up until they opt out or are vaccinated
We should be rolling out the vaccine like we do the Census, even going door-to-door
2/ Remove barriers & be redundant
In each community, have multiple ways to get vaccinated including CVS/Walgreens, pop-up sites & near high-throughput places people have to to go like grocery stores
Make some venues 24/7 so people can get vaccinated anytime that works for them
In 2014, I was on a 'task force' convened by Guinea's President to forge a nat'l Ebola response
Cases were spiking, it was a polarizing election year &, though many efforts were happening, there was no overall strategy or unified response
Here's how we set up the response
1/15
The first step was to establish a clear chain-of-command leadership structure under the National Ebola Coordination Cell with Dr Sakoba Keita as its head
All partners (eg, WHO, MSF, other ministries) & all response activities had to go through the Cell
2/15
We then created an overarching national strategy that included all interventions (eg, testing, contact tracing)
This wasn't just a laundry list of things that could help but aimed to spell out the combo of measures needed to actually reach zero within a defined timeframe
(2/3) #1 can be achieved by merging best practices that thus far happen in isolation into integrated systems that leverage technological- connectivity, AI, automation- tools to orchestrate/facilitate high-quality replicable execution at scale
(3/3) #2 is less of a technical & logistical challenge than a human, social & political one & therefore much more complicated to find a clear path towards achieving but achieve it we must
(1/5) To put Trump being started on dexamethasone in perspective, we do it for patients when they become hypoxic
Some patients I've had are on remdesivir/dexa like Trump is now & only require a touch of oxygen (eg, 2L) for a day or two & then come off it.
(2/5) Even when on oxygen, they may look, feel, talk etc. like they're fine & you wouldn't know they were hypoxic unless you took off the oxygen & saw their O2 saturation
(3/5)Others on remdesivir/dexa end up as sick as anyone can be including on a ventilator, paralytics, etc & either pass away or recover after a prolonged & arduous course
Bottom line: there's huge variation which makes it tough to pinpoint where someone might be on that spectrum
(1/4) Other than the experimental antibodies, Trump has gotten what - remdesivir, dexamethasone - we give to our Covid patients with hypoxia
(2/4) From the way questions were answered, the fact that dex was started (which can have side effects including confusion) & he was on supplemental O2 suggests to me that his O2 may have been lower than they are letting on
Supplemental O2 usually isn't given unless O2 sat <90%
(3/4) With Covid19 & pneumonias in general, you typically don't get 'transient' drops in O2 as much as persistent (& potentially progressive) hypoxia lasting for at least hours
Transient drops usually happen from mucous plugs or aspiration