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Eric Topol Profile picture
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14 Mar, 4 tweets, 2 min read
The new wave taking hold in Europe and South America
@OurWorldInData
Not just Central Europe, now many western countries are rising and attributing this to the B.1.1.7 strain
Most countries in South America are ascending, especially Brazil
Meant to include Asia, too (little overall change)

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More from @EricTopol

Eric Topol Profile picture
13 Mar
NEW RECORD and a big jump from the one set yesterday
4.58 vaccine doses in the US today!
And a new Y-axis.
That's 4.58 million.
It's remarkable, to say the least.
It reflects tens of thousand of volunteers, health professionals to get this done. On Saturday, no less.🙏🙏
It is= to getting jabs in over 2.2 % of American adults in 1 day
👍👏👏💪
If we prevent the B.1.1.7 strain hit in the next few weeks, which is looking more likely each day, it'll be largely attributable to how this country stepped up with vaccination.
Now (@CDCgov) almost 21% of all Americans, and 63% age ≥ 65 with ≥ 1 dose. Phenomenal progress.
Read 4 tweets
Eric Topol Profile picture
6 Mar
The spectrum of covid illness and effect of the vaccines in clinical trials
1. The trials were designed and powered for protection from mild to moderate illness. Not severe infections. Not asymptomatic infections. Not hospitalizations or deaths. Not #LongCovid. Image
2. The Table summarizes the data to point out how few severe endpoints occurred. The largest N of endpoints was in the J&J trial and <10% fell into the "severe" category. All together for over 152,000 participants, <100 severe endpoints. Image
3. We registered concern last fall about this matter, that there will be inadequate events/statistical power to judge severe infections and outcomes nytimes.com/2020/09/22/opi… Image
Read 12 tweets
Eric Topol Profile picture
5 Mar
How to fix the "scariant" problem, the fear from #SARSCoV2 variants that are incompletely characterized
@WIRED by @MeganMolteni
wired.com/story/the-us-h…
Our @ScrippsResearch, "Science Simplified," 2 min educational video on variants
…
@drewduglan and @WardLab1 @HaileePerrett
Is a new Oregon variant functionally different?
It's too early to tell
nytimes.com/2021/03/05/hea…
I coined the term "scariant" because there's a mixed bag of real troubling variants (like B.1.1.7, P.1, B.1.351) + many that are not adequately characterized, may lack need for concern
Read 4 tweets
Eric Topol Profile picture
24 Feb
The @JNJNews vaccine FDA briefing documents are out, so we now can see how well this single adenovirus vector vaccine dose works
fda.gov/media/146217/d…
1. It is efficacious, overall 66%, but not as high as the mRNA vaccines (even in US with D614G strain).
2. While 85% efficacy was seen for severe infections, there was some falloff in participants > 60 yrs of age
3. A look at asymptomatic infections (carrier state) suggests the efficacy for reducing that is similar to overall efficacy
Read 7 tweets
Eric Topol Profile picture
23 Feb
There's a problem with labelling the California variant (B.1.427/B.1.429) "increasingly dangerous" when there isn't even a preprint published and we're watching dramatic descent in cases, hospitalization and deaths despite its high frequency
latimes.com/science/story/…
More @nytimes on this today, without the "dangerous" stuff.
But I am not convinced there is any meaningful functional difference for this "California variant" in light of above comment (the real laboratory is what is going on in California)
nytimes.com/2021/02/23/hea… by @carlzimmer
And @NewsfromScience
“If I were a reviewer, I would want to see more data from more infected people to substantiate this very provocative claim” -- Prof David O’Connor @dho (+1)
sciencemag.org/news/2021/02/c… by @meredithwadman
Read 4 tweets
Eric Topol Profile picture
21 Feb
Preprints weren't enough.
Now we've got the "leaked" report + cognitive bias.
We all want to see vaccines block spread—faster end of the pandemic and need for masks
The leaked Israeli Ministry of Health report, 1st reported by @Nadav_Eyal, then by @techreview. gets much attention
The bold conclusion above is not only based on "sketchy" data, according to @Nadav_Eyal, but now being promoted as breaking news by @bloomberg
It's certainly possible that the vaccine achieves ~90% reduction in spread, but we're not there yet— even though it's the news we all want to see. Nothing like the combo of a "leaked" report and hunger for good news.
Read 4 tweets

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