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Eric Feigl-Ding Profile picture
@DrEricDing
Mar 20, 2021 • 29 tweets • 20 min read • Read on X
B117 variant is now *dominant* in the US. I’m 99% certain that another surge is on the way in April or May. Why? The more contagious #B117 is surging—now crossed the 50% threshold of all cases, in addition to pockets of others variants. 🧵 #COVID19
washingtonpost.com/opinions/2021/… Image
2) Just Wednesday, #B117 has hit 50% of all cases in the @my_helix database nationwide. It’s been exponentially surging for weeks. Image
3) @ashishkjha is right- “No matter where you live, it is too early to relax restrictions that continue to have a critical role in controlling this pandemic. From CA to ME, FL to Seattle, the #COVID19 winter is not yet done—highly infectious variants are threatening new storms.”
4) “But the latest national data, which show case rates have plateaued, indicate that we are not there yet. Over the past week, we have seen about 50,000 new cases reported daily. That’s not far from the **height of the surge last summer**”
5) Unfortunately, the public has been served the "it's-under-control" nonsense, pictured on panel A. But the reality is that it is exponentially even it growing slowly - because that’s how ever exponential function starts. It always sneaks ups.

(Figure by @GosiaGasperoPhD) Image
6) Take Alberta 🇨🇦 for example—people dismissed it for weeks. But the data is playing out exactly and predicted...

(Figure by @GosiaGasperoPhD). Image
7) We had predicted the graph above long ago... here was over a month ago... does it look familiar? It’s almost exactly the shape of the graph above.
8) Back to the US — Florida #B117 is hovering around 51% range. Florida’s decline has now stalled. Image
9) But there is a new champion in #B117 lead— 61% #B117 in Georgia, where cases has been rising daily for last 5 days. Image
10) And how is Michigan doing in #B117? It tops even Georgia. Michigan #B117 is now 62.5%. How is Michigan cases doing? Also surging in March. ImageImage
11) it was previously predicted that #B117 would pass 50% previously (@K_G_Andersen’s group) on March 23rd nationwide in the US.

We just passed it early... 6 days early. Damn.
12) Almost every epidemiologist agrees a 4th surge is coming. It is almost inevitable. The only question is how bad will it be. Maybe not that bad if we vaccinate faster. washingtonpost.com/opinions/2021/…
13) What makes me sad is that, aside from Australia, New Zealand, Vietnam, and Taiwan (all ~zero Covid countries) we never act fast enough until it is much too late. Leadership failures.

Correction- this figure is by @vb_jens. Image
14) But there are other variants to worry about too. In he UK and France, the South Africa #B1351 is also rising steadily. Here is a good thread 🧵 on their rise in the UK. The SA variant is the most problematic in vaccine lab studies so far.

Image
15) Notably, in the large study of Pfizer and NIH-Moderna vaccinated people, the 🇿🇦 #B1351 variant is the most troublesome. (This thread 🧵 below has been vetted and concurred by 2 immunology colleagues).

Good news is #B117 responds well to the vaccines! so take it!
16) I also want everyone to look carefully just how gosh darn PERFECTLY ACCURATE the Feb 1st model by @GosiaGasperoPhD was to the reality currently. Her forecasts were always exactly as predicted.

Hence let’s please not relax too soon. Surge is coming.
Image
17) This is why even with vaccinations, we have to be vigilant — relaxing everything else in terms of mitigation is a recipe for disaster until we have vaccinated up to vaccine herd immunity thresholds — likely 85% range for #B117 given its higher contagiousness.
18) And please continue to mask even if vaccinated due to residual chance of carrying virus. And definitely do NOT rely on prior #COVID19 infection for sufficient protection. It’s only 47% in the elderly!
19) Notice the sharp dropoff in the protection from reinfection by age. It’s only ~80% under 65, but only 47% in those 65 or older!

Also semi good news is that protection seems to be as good over 7 months. But not that high.

thelancet.com/action/showPdf… Image
20) meantime—I’m more worried about #P1–here is the ominous study on #P1 variant that is now everywhere in 🇧🇷... it is 2.52x faster transmission that old wild common type of #SARSCoV2. That is 152% increase! #B117 is only 40-60% faster.

medrxiv.org/content/10.110… Image
21) Another Brazil 🇧🇷 #COVID19 research group puts #P1 transmission at 2x faster than old strain (instead of 2.5x above), but they estimate a way worse whopping 25-60% reinfection rate! Ugh.

I’m honestly not sure which is worse. Both models really bad. bbc.com/news/amp/healt…
22) to be clear—the Pfizer and Moderna vaccines works against #B117–lots of studies. But for the #P1 and #B1351 variants, neutralization of the pseudovirus in lab by vaccine sera shows slight issues with #P1 and bigger issues with #B1351. We need to urgently chase #ZeroCovid. ImageImage
23) I’m a big fan of the J&J single dose vaccine — it not only grows stronger over time, but it also has good efficacy in both South Africa and Brazil! (Albeit before #P1 became heavily dominant in Brazil).
24) But I’m worried about #P1 and #B117 most of all. #P1 especially because it poses both potential reinfection risk and possibly faster transmission than even the already faster #B117 (see above). We need to keep #P1 contained in Brazil and squash out all 🌎 scattered #P1 cases.
25) Because we can’t let what’s happening in Brazil keep happening... or let it happen to other countries.

The world needs to unite together during a pandemic with the 3 Musketeers’ “ALL FOR ONE, ONE FOR ALL” motto. Or else we will sink as one planet. Image
26) Now the US needs to share its vaccine stockpile and vaccine excess orders with the world. And send aid to Brazil 🇧🇷. Or else we will all drown under the variants.

Let’s unite to fight this pandemic... all for one, one for all!

God help us.
27) I’m so tired... been trying to warn about this exact #B117 for over 6 weeks. So so tired.
28) things in South Florida are going as well as can be expected... #B117 variant surging there.

Why do we ignore this warning sign? I didn’t suffer through a doctorate in epidemiology by age 23, just so that DeSantis can pretend to govern in a pandemic.
sun-sentinel.com/coronavirus/fl…
29) #B117 update—Germany entering a new stricter lockdown after #B117 is growing and fueling another increase across EU.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Apr 13
📈Measles epidemic trajectory is worsening in the U.S.—it has NOT flattened as some claimed. The surge continues—comparison of newest versus recent outbreak graph. Majority are unvaccinated, but there’s enough unvaccinated in many clusters for outbreaks.
cnn.com/health/measles…

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2) here is another way to visualize the measles epidemic. Another annoying thing is that although 95% not double vaccinated, 5% of the previous 113 cases were vaccinated— which means that there is waning immunity or vaccine breakthrough with sufficiently big outbreak possible.
3) I specifically wanted about this issue that pockets of unvaccinated could still trigger outbreaks, and vaccine breakthroughs possible due to vaccine waning & if surrounded by pockets of low vaccinations. See my warning oped below. 👇
Read 6 tweets
Eric Feigl-Ding Profile picture
Apr 10
🐄—"Experts fear that H5N1 avian flu… may have been transmitted through a type of cattle feed called “poultry litter”—mix of poultry poop, spilled feed, feathers, and other waste scraped from the floors of industrial chicken and turkey production plants."
telegraph.co.uk/global-health/…
Europe does not allow cattle to be fed poultry feed. US does. This helps explain why US is seeing a cow outbreak of avian flu.
3) CDC warns against chicken and bird exposures and direct contact with poop. Yet why the hell are we feeding cattle poultry litter??? Corporate farms are so stupid and greedy.
Read 8 tweets
Eric Feigl-Ding Profile picture
Apr 9
Global CO2 levels and temperatures. But but but we scientists are merely “fear mongering” according to deniers. How about just facing reality? How about precautionary warnings to protect human lives?

@ed_hawkins @MrMatthewTodd #climatecrisis Image
Oh this seems totally fine.
Image
I think we are screwed at this point on limiting temperature rise by 1.5 C. It’ll still take a miracle to avoid 2 C.
Read 5 tweets
Eric Feigl-Ding Profile picture
Apr 8
📍BIRD HUNTING AVIAN FLU DEATH—WHO reports that a 21 year old young man with no underlying conditions suddenly died of #avianflu in Vietnam. He started with a cough/fever, but died 12 days later with severe pneumonia and ARDS. ➡️He had only gone bird hunting recently. BE CAREFUL.
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2) "From 2003 to 25 March 2024, a total of 888 worldwide human cases of influenza A(H5N1), 463 deaths (52% CFR), reported to WHO from 23 countries. Almost all cases of human infection with avian influenza A(H5N1) linked to close contact with infected live or dead birds, or contaminated environments."
who.int/emergencies/di…
3) It is interesting that WHO had to point out he had no contact with any sick or dead birds. Only hunting. And he had gone bird hunting the prior month in Feb 2024. And no other contact with people since. The latency period seems rather long.
Read 8 tweets
Eric Feigl-Ding Profile picture
Apr 6
⚠️SPIKE IN MEASLES—113 cases of US measles in Q1 of 2024, double the total for all of 2023. 📍95% of the cases were in those without 2 full doses of MMR💉vaccine (83% cases without any confirmed shots). Across 18 states—top 2 states are Illinois & Florida. 58% of all cases got hospitalized🏥—66% of infected kids <5 years old hospitalized. 61% of adults 20+ hospitalized. Please take measles seriously. Don’t listen to RFK Jr.
cdc.gov/measles/cases-…Image
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2) Moreover, many of the nationwide cases had come from Florida— “Measles cases that turned up in at least three states this year were linked to visits to Florida, federal and state investigators concluded”. FL also doesn’t count non-residents as cases.🤦🏻‍♂️

cbsnews.com/amp/news/measl…
3) I wrote a long WARNING last month about measles surging in the U.S. — we are not addressing the crisis. Florida measles crisis is just a bell weather. And now here we are.

Please take a moment to read— 👇

With @kavitapmd @yaneerbaryam

ca.news.yahoo.com/florida-measle…
Read 6 tweets
Eric Feigl-Ding Profile picture
Apr 5
📍CAUTIONARY CAT FOOD OUTBREAK—38 cats died eating #AvianFlu-tainted cat food in an 🇰🇷outbreak last year. Specifically—38 out of the 40 infected shelter cats died within a month—all were kept indoors. Investigators with South Korea’s Ministry of Agriculture, Food and Rural Affairs (MAFRA) detected influenza A(#H5N1) virus in cat food. MAFRA officials then ordered the recall of all cat food batches considered at risk of harboring the virus. The bird flu virus entered the cat food stream during an outbreak of the virus on poultry🐓 farms.
petfoodindustry.com/safety-quality…Image
2) Outbreak of avian flu in cats, and subsequent cat deaths has been common—another outbreak in Poland killed 25 cats 🐈‍⬛ in June 2023, reported by the WHO.

“On 27 June 2023, the IHR National Focal Point of Poland notified WHO of unusual deaths in cats across the country. As of 11 July, 47 samples have been tested from 46 cats and one captive caracal, of which 29 were found to be positive for influenza A (H5N1). Fourteen cats are reported to have been euthanized, and a further 11 died, with the last death reported on 30 June.”

who.int/emergencies/di…
3) cats and dogs have died eating infected birds. This has been well documented in the past. Lesson again is make sure food is cooked / sanitary. The cat food manufacturing error with the tainted cat food was hopefully one time thing — but it’s a lesson in the spread.
Read 5 tweets

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