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Eric Feigl-Ding Profile picture
@DrEricDing
Mar 20, 2021 • 29 tweets • 20 min read • Read on X
B117 variant is now *dominant* in the US. I’m 99% certain that another surge is on the way in April or May. Why? The more contagious #B117 is surging—now crossed the 50% threshold of all cases, in addition to pockets of others variants. 🧵 #COVID19
washingtonpost.com/opinions/2021/… Image
2) Just Wednesday, #B117 has hit 50% of all cases in the @my_helix database nationwide. It’s been exponentially surging for weeks. Image
3) @ashishkjha is right- “No matter where you live, it is too early to relax restrictions that continue to have a critical role in controlling this pandemic. From CA to ME, FL to Seattle, the #COVID19 winter is not yet done—highly infectious variants are threatening new storms.”
4) “But the latest national data, which show case rates have plateaued, indicate that we are not there yet. Over the past week, we have seen about 50,000 new cases reported daily. That’s not far from the **height of the surge last summer**”
5) Unfortunately, the public has been served the "it's-under-control" nonsense, pictured on panel A. But the reality is that it is exponentially even it growing slowly - because that’s how ever exponential function starts. It always sneaks ups.

(Figure by @GosiaGasperoPhD) Image
6) Take Alberta 🇨🇦 for example—people dismissed it for weeks. But the data is playing out exactly and predicted...

(Figure by @GosiaGasperoPhD). Image
7) We had predicted the graph above long ago... here was over a month ago... does it look familiar? It’s almost exactly the shape of the graph above.
8) Back to the US — Florida #B117 is hovering around 51% range. Florida’s decline has now stalled. Image
9) But there is a new champion in #B117 lead— 61% #B117 in Georgia, where cases has been rising daily for last 5 days. Image
10) And how is Michigan doing in #B117? It tops even Georgia. Michigan #B117 is now 62.5%. How is Michigan cases doing? Also surging in March. ImageImage
11) it was previously predicted that #B117 would pass 50% previously (@K_G_Andersen’s group) on March 23rd nationwide in the US.

We just passed it early... 6 days early. Damn.
12) Almost every epidemiologist agrees a 4th surge is coming. It is almost inevitable. The only question is how bad will it be. Maybe not that bad if we vaccinate faster. washingtonpost.com/opinions/2021/…
13) What makes me sad is that, aside from Australia, New Zealand, Vietnam, and Taiwan (all ~zero Covid countries) we never act fast enough until it is much too late. Leadership failures.

Correction- this figure is by @vb_jens. Image
14) But there are other variants to worry about too. In he UK and France, the South Africa #B1351 is also rising steadily. Here is a good thread 🧵 on their rise in the UK. The SA variant is the most problematic in vaccine lab studies so far.

Image
15) Notably, in the large study of Pfizer and NIH-Moderna vaccinated people, the 🇿🇦 #B1351 variant is the most troublesome. (This thread 🧵 below has been vetted and concurred by 2 immunology colleagues).

Good news is #B117 responds well to the vaccines! so take it!
16) I also want everyone to look carefully just how gosh darn PERFECTLY ACCURATE the Feb 1st model by @GosiaGasperoPhD was to the reality currently. Her forecasts were always exactly as predicted.

Hence let’s please not relax too soon. Surge is coming.
Image
17) This is why even with vaccinations, we have to be vigilant — relaxing everything else in terms of mitigation is a recipe for disaster until we have vaccinated up to vaccine herd immunity thresholds — likely 85% range for #B117 given its higher contagiousness.
18) And please continue to mask even if vaccinated due to residual chance of carrying virus. And definitely do NOT rely on prior #COVID19 infection for sufficient protection. It’s only 47% in the elderly!
19) Notice the sharp dropoff in the protection from reinfection by age. It’s only ~80% under 65, but only 47% in those 65 or older!

Also semi good news is that protection seems to be as good over 7 months. But not that high.

thelancet.com/action/showPdf… Image
20) meantime—I’m more worried about #P1–here is the ominous study on #P1 variant that is now everywhere in 🇧🇷... it is 2.52x faster transmission that old wild common type of #SARSCoV2. That is 152% increase! #B117 is only 40-60% faster.

medrxiv.org/content/10.110… Image
21) Another Brazil 🇧🇷 #COVID19 research group puts #P1 transmission at 2x faster than old strain (instead of 2.5x above), but they estimate a way worse whopping 25-60% reinfection rate! Ugh.

I’m honestly not sure which is worse. Both models really bad. bbc.com/news/amp/healt…
22) to be clear—the Pfizer and Moderna vaccines works against #B117–lots of studies. But for the #P1 and #B1351 variants, neutralization of the pseudovirus in lab by vaccine sera shows slight issues with #P1 and bigger issues with #B1351. We need to urgently chase #ZeroCovid. ImageImage
23) I’m a big fan of the J&J single dose vaccine — it not only grows stronger over time, but it also has good efficacy in both South Africa and Brazil! (Albeit before #P1 became heavily dominant in Brazil).
24) But I’m worried about #P1 and #B117 most of all. #P1 especially because it poses both potential reinfection risk and possibly faster transmission than even the already faster #B117 (see above). We need to keep #P1 contained in Brazil and squash out all 🌎 scattered #P1 cases.
25) Because we can’t let what’s happening in Brazil keep happening... or let it happen to other countries.

The world needs to unite together during a pandemic with the 3 Musketeers’ “ALL FOR ONE, ONE FOR ALL” motto. Or else we will sink as one planet. Image
26) Now the US needs to share its vaccine stockpile and vaccine excess orders with the world. And send aid to Brazil 🇧🇷. Or else we will all drown under the variants.

Let’s unite to fight this pandemic... all for one, one for all!

God help us.
27) I’m so tired... been trying to warn about this exact #B117 for over 6 weeks. So so tired.
28) things in South Florida are going as well as can be expected... #B117 variant surging there.

Why do we ignore this warning sign? I didn’t suffer through a doctorate in epidemiology by age 23, just so that DeSantis can pretend to govern in a pandemic.
sun-sentinel.com/coronavirus/fl…
29) #B117 update—Germany entering a new stricter lockdown after #B117 is growing and fueling another increase across EU.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Nov 13
⚠️BREAKING—ICU Hospitalized human bird flu case in Canada now officially confirmed as H5N1. Worse, it is the same 2.3.4.4b virus clade (variant group) as the one found in BC🇨🇦 poultry and in Washington state🇺🇸! The hospitalized teenager (with no pre existing conditions) had no animal contact, does not live on farm, had “deterioration quite rapid” and now critical in ICU with ARDS. Canada officials says infectious period is 2 days **prior to symptoms** (ie asymptomatic transmission) and infectious up to 10 days.Image
2) Public Health Agency of Canada's National Microbiology Laboratory (NML) in Winnipeg confirmed that the individual has avian influenza H5N1
canada.ca/en/public-heal…
3) details…

⚠️BAD UPDATE—BIRD FLU HOSPITALIZATION IN CANADIAN TEEN

Summary 🧵 of the live press conference with Canada’s British Columbia health officer.

📌The teen is in intensive care.
📌Condition is ARDS
📌Teen was healthy prior; no underlying conditions

bsky.app/profile/dreric…
Read 4 tweets
Eric Feigl-Ding Profile picture
Nov 13
Trump’s incoming SECRETARY OF DEFENSE who doesn’t wash his hands and doesn’t believe in germs. Image
2) Trump’s new SECDEF is also in favor of committing war crimes. businessinsider.com/pete-hegseth-a…
3) Trump’s SECDEF pick is a wild character. And loves hawking merch.
Read 4 tweets
Eric Feigl-Ding Profile picture
Nov 9
My god—Google Search for “what is a tariff” sudden spikes the DAY AFTER ELECTION DAY. 🤦🏻‍♂️ Image
2) many folks simply don’t understand what a tariff is — unless you explain it several times to them with analogies. Even then, it’s hard for many to grasp. Eg 👇
3) Ah shit… it’s now gotten worse. Why do so many people do their hw late??,
Read 6 tweets
Eric Feigl-Ding Profile picture
Nov 6
📍HARRIS IS STILL AHEAD IN PA—in terms of votes yet to be counted. She’s still +2 of what is needed to win PA, given the outstanding votes still remaining in PA cities, according to @CBSNews @NorahODonnell Image
Image
Image
Harris has enough remaining in PA Philly suburbs to still win. Image
3) folks. The NYT needle is not reliable.
Read 5 tweets
Eric Feigl-Ding Profile picture
Oct 31
Plastic cookware should not be used. Period. Especially BLACK PLASTIC cookware, that often mixes in toxic recycled electronic waste materials. DISPOSE OF ALL PLASTIC COOKWARE, especially if black colored plastic ones. Pass it on to your family.

Gift🎁🔗
theatlantic.com/health/archive…Image
2) Because optical sensors in recycling facilities can’t detect them, black-colored plastics are largely rejected from domestic-waste streams, resulting in a shortage of black base material for recycled plastic. So the demand for black plastic appears to be met “in no insignificant part” via recycled e-waste, according to Turner’s research. TV and computer casings, like the majority of the world’s plastic waste, tend to be recycled in informal waste economies with few regulations and end up remolded into consumer products, including ones, such as spatulas and slotted spoons, that come into contact with food.
3) You simply do not want flame retardants anywhere near your stir-fry. Flame retardants are typically not bound to the polymers to which they are added, making them a particular flight risk: They dislodge easily and make their way into the surrounding environment. And, indeed, another paper from 2018 found that flame retardants in black kitchen utensils readily migrate into hot cooking oil. The health concerns associated with those chemicals are well established: Some flame retardants are endocrine disruptors, which can interfere with the body’s hormonal system, and scientific literature suggests that they may be associated with a range of ailments, including thyroid disease, diabetes, and cancer. People with the highest blood levels of PBDEs, a class of flame retardants found in black plastic, had about a 300 percent increase in their risk of dying from cancer compared with people who had the lowest levels, according to a study released this year. In a separate study, published in a peer-reviewed journal this month, researchers from the advocacy group Toxic-Free Future and from Vrije Universiteit Amsterdam found that, out of all of the consumer products they tested, kitchen utensils had some of the highest levels of flame retardants.
Read 4 tweets
Eric Feigl-Ding Profile picture
Oct 29
⚠️MASK MANDATE RETURNING TO ALL NIH PATIENT CLINICS—Effective November 4, 2024, masking will be required in all patient care & waiting rooms. Furthermore, testing for COVID, flu A, flu B, and RSV will be required for all inpatients & rooming-in visitors.
cc.nih.gov/patient-servic…Image
Image
2) This means wearing a mask will be REQUIRED in all patient care areas, including waiting rooms. ➡️This change is due to an anticipated increase in COVID-19 and other respiratory virus activity in the community. 😷
3) I think people should stock up on COVID tests again. The Cheapest COVID test on the U.S. market is now as low as $1.50 with special promo code “COV20”… expiring Jan or March 2025.

store.pharmalynk.com/products/advin…Image
Read 6 tweets

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