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Eric Topol Profile picture
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25 Mar, 6 tweets, 3 min read
How to be a superhuman vs. #SARSCoV2?
Get vaccinated
Why do you become a superhuman?
1. Levels of neutralizing antibody for vaccine >> natural infection
2. Protection w/ vaccine additive to prior infection
3. Protection vs. variants: vaccine > natural immunity
4. Less reinfection
by @DennisRBurton and me @NatureMedicine nature.com/articles/s4159…
Multiple papers in this thread to support the assertion
This @ScienceMagazine paper from today
This new preprint on convalescent plasma (prior infection) on left vs vaccine for the NY variant (B.1.526) at right
biorxiv.org/content/10.110… (same Y-axis) Order of magnitude more neutralizing antibody with vaccines

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More from @EricTopol

Eric Topol Profile picture
24 Mar
How do you know that B.1.1.7 is dominant in Michigan?
When it has its highest number of new cases in a day in over 3 months
Image
Just as was seen in Israel, vaccination protection for older individuals with case and hospitalizations predominantly in younger, non-vaccinated. And reminder: the vaccines work very well vs B.1.1.7 freep.com/story/news/loc…
A big boost in vaccine distribution and support for administering mass vaccination in Michigan is warranted ImageImage
Read 4 tweets
Eric Topol Profile picture
23 Mar
Very good news @NEJM today on vaccine effectiveness in the US and Israeli healthcare workforce
1. @UTSWNews health system over 23,000 employees, 70% vaccinated, had a dramatic reduction of infections
nejm.org/doi/full/10.10…
2. And similarly @UCSDHealth @UCLAHealth over 36,000 health care workers were vaccinated nejm.org/doi/full/10.10…
3. And concordant with a 3rd report of vaccinations among health care workers in Israel nejm.org/doi/full/10.10…
Read 4 tweets
Eric Topol Profile picture
23 Mar
This @AstraZeneca statement in response to the @NIH press release is unacceptable. They know exactly what is going on w/r to the time cutoff for 1° analysis, which appears to be at odds with the independent Data and Safety Monitoring Board. It should not take 48 hrs to sort out
The DSMB, consisting of 11 independent experts who have been overseeing the trial from its outset through its completion, says the primary analysis showed efficacy between 69-74%. Let's see all the data @AstraZeneca washingtonpost.com/world/astrazen…
Let's be clear. This is *not* about the vaccine. It is about @AstraZeneca, their own worst enemy, with an apparent breach of integrity on data dissemination. And where is the @UniofOxford on this, their partner?
Read 5 tweets
Eric Topol Profile picture
17 Mar
The Astra Zeneca vaccine turmoil as headlines today and tomorrow
This has moved from a very small number of clotting events w/ a vast denominator -> international dismay, characterized as "political" in the update👇-> to (sadly) a crisis in confidence nytimes.com/2021/03/16/wor…
I'd like to see fully dataset for the clotting events, particularly the 7 cavernous sinus thrombosis cases in Germany (out of 1.6 million vaccinated), all cases of immune thrombocytopenia (ITP). ITP has been very rarely reported, associated w/ Pfizer/Moderna vaccines /2
Of course, association ≠ causation. More common events like DVT/PE (majority of the reports) would be fully expected and v unlikely related to vaccination. Releasing all the data (rather than EMA/WHO statements) can help bolster trust for the medical community to patients /f
Read 5 tweets
Eric Topol Profile picture
14 Mar
The new wave taking hold in Europe and South America
@OurWorldInData
Not just Central Europe, now many western countries are rising and attributing this to the B.1.1.7 strain
Most countries in South America are ascending, especially Brazil
Read 4 tweets
Eric Topol Profile picture
13 Mar
NEW RECORD and a big jump from the one set yesterday
4.58 vaccine doses in the US today!
And a new Y-axis.
That's 4.58 million.
It's remarkable, to say the least.
It reflects tens of thousand of volunteers, health professionals to get this done. On Saturday, no less.🙏🙏
It is= to getting jabs in over 2.2 % of American adults in 1 day
👍👏👏💪
If we prevent the B.1.1.7 strain hit in the next few weeks, which is looking more likely each day, it'll be largely attributable to how this country stepped up with vaccination.
Now (@CDCgov) almost 21% of all Americans, and 63% age ≥ 65 with ≥ 1 dose. Phenomenal progress.
Read 4 tweets

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