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23 Mar, 5 tweets, 4 min read
This @AstraZeneca statement in response to the @NIH press release is unacceptable. They know exactly what is going on w/r to the time cutoff for 1° analysis, which appears to be at odds with the independent Data and Safety Monitoring Board. It should not take 48 hrs to sort out
The DSMB, consisting of 11 independent experts who have been overseeing the trial from its outset through its completion, says the primary analysis showed efficacy between 69-74%. Let's see all the data @AstraZeneca washingtonpost.com/world/astrazen…
Let's be clear. This is *not* about the vaccine. It is about @AstraZeneca, their own worst enemy, with an apparent breach of integrity on data dissemination. And where is the @UniofOxford on this, their partner?
You have these data, @AstraZeneca. Please fill in this table
Update on this saga with more on the conflict between the DSMB and Astra Zeneca nytimes.com/2021/03/23/bus… by @RebeccaDRobbins @SharonLNYT @noahweiland
Meanwhile, it could get resolved right away by the company filling out the table, being fully transparent

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More from @EricTopol

Eric Topol Profile picture
23 Mar
Very good news @NEJM today on vaccine effectiveness in the US and Israeli healthcare workforce
1. @UTSWNews health system over 23,000 employees, 70% vaccinated, had a dramatic reduction of infections
nejm.org/doi/full/10.10… Image
2. And similarly @UCSDHealth @UCLAHealth over 36,000 health care workers were vaccinated nejm.org/doi/full/10.10… ImageImage
3. And concordant with a 3rd report of vaccinations among health care workers in Israel nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Eric Topol Profile picture
17 Mar
The Astra Zeneca vaccine turmoil as headlines today and tomorrow
This has moved from a very small number of clotting events w/ a vast denominator -> international dismay, characterized as "political" in the update👇-> to (sadly) a crisis in confidence nytimes.com/2021/03/16/wor…
I'd like to see fully dataset for the clotting events, particularly the 7 cavernous sinus thrombosis cases in Germany (out of 1.6 million vaccinated), all cases of immune thrombocytopenia (ITP). ITP has been very rarely reported, associated w/ Pfizer/Moderna vaccines /2
Of course, association ≠ causation. More common events like DVT/PE (majority of the reports) would be fully expected and v unlikely related to vaccination. Releasing all the data (rather than EMA/WHO statements) can help bolster trust for the medical community to patients /f
Read 5 tweets
Eric Topol Profile picture
14 Mar
The new wave taking hold in Europe and South America
@OurWorldInData
Not just Central Europe, now many western countries are rising and attributing this to the B.1.1.7 strain
Most countries in South America are ascending, especially Brazil
Read 4 tweets
Eric Topol Profile picture
13 Mar
NEW RECORD and a big jump from the one set yesterday
4.58 vaccine doses in the US today!
And a new Y-axis.
That's 4.58 million.
It's remarkable, to say the least.
It reflects tens of thousand of volunteers, health professionals to get this done. On Saturday, no less.🙏🙏
It is= to getting jabs in over 2.2 % of American adults in 1 day
👍👏👏💪
If we prevent the B.1.1.7 strain hit in the next few weeks, which is looking more likely each day, it'll be largely attributable to how this country stepped up with vaccination.
Now (@CDCgov) almost 21% of all Americans, and 63% age ≥ 65 with ≥ 1 dose. Phenomenal progress.
Read 4 tweets
Eric Topol Profile picture
6 Mar
The spectrum of covid illness and effect of the vaccines in clinical trials
1. The trials were designed and powered for protection from mild to moderate illness. Not severe infections. Not asymptomatic infections. Not hospitalizations or deaths. Not #LongCovid. Image
2. The Table summarizes the data to point out how few severe endpoints occurred. The largest N of endpoints was in the J&J trial and <10% fell into the "severe" category. All together for over 152,000 participants, <100 severe endpoints. Image
3. We registered concern last fall about this matter, that there will be inadequate events/statistical power to judge severe infections and outcomes nytimes.com/2020/09/22/opi… Image
Read 12 tweets
Eric Topol Profile picture
5 Mar
How to fix the "scariant" problem, the fear from #SARSCoV2 variants that are incompletely characterized
@WIRED by @MeganMolteni
wired.com/story/the-us-h…
Our @ScrippsResearch, "Science Simplified," 2 min educational video on variants
…
@drewduglan and @WardLab1 @HaileePerrett
Is a new Oregon variant functionally different?
It's too early to tell
nytimes.com/2021/03/05/hea…
I coined the term "scariant" because there's a mixed bag of real troubling variants (like B.1.1.7, P.1, B.1.351) + many that are not adequately characterized, may lack need for concern
Read 4 tweets

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