“Out of 220 countries and economies, 194 have now started vaccination and 26 have not”, says @DrTedros at #covid19 @WHO presser. “Of those, seven have received vaccines and could start, and a further five countries should receive their vaccines in the coming days."
@DrTedros @WHO (Tomorrow is day 100 of the year and @WHO had called on vaccinations against #covid19 to begin in all countries within the first 100 days of the year.)
@DrTedros @WHO The remaining 14 countries have not yet begun #Covid19 vaccination for a range of reasons, says @DrTedros. "Some have not requested vaccines through COVAX, some are not yet ready, and some plan to start in the coming weeks and months."
@DrTedros @WHO COVAX has delivered more than 38 million doses to more than 100 countries and economies in the past six weeks, says @DrTedros. "We’re encouraged that almost all countries who want to start have now started”, he says. "However, I emphasize the word ’start’”.
@DrTedros @WHO “There remains a shocking imbalance in the global distribution of vaccines”, says @DrTedros.
"On average, in high income countries, almost one in four people has received a vaccine.
In low income countries, it's one in more than 500."
@DrTedros @WHO COVAX had been expecting to distribute close to 100 million doses by the end of March, says @DrTedros.
“Due to a marked reduction in supply, we have only been able to distribute 38 million doses.
We hope to be able to catch up during April and May."
@DrTedros @WHO Ongoing discussions with Indian government about vaccine supply from the Serum Institute of India, says @DrTedros.
"We're working to accelerate the release and rollout of vaccines from SKBio in the Republic of Korea. We're trying to expedite the delivery of the J&J vaccine.”
@DrTedros @WHO "We're continuing to seek donations of doses from countries who have enough to cover their entire population several times over”, says @DrTedros.
“We're expediting the review of more vaccines, including from Sinopharm, Sinovac and Gamaleya."
@DrTedros @WHO “We still have an enormous amount of work ahead of us as we seek to deliver at least 2 billion doses this year, which includes securing access and funding for 1.8 billion doses on behalf of the 92 lower income economies”, says @GaviSeth.
@DrTedros @WHO @GaviSeth “We need continued support from governments and manufacturers, because every time a bilateral deal gets done around the COVAX facility, it means less doses for COVAX and for equitable distribution”, says @GaviSeth.
@DrTedros @WHO @GaviSeth “We're now beginning to see supply constraints, not just of vaccines, but also of the goods that go into making vaccines”, says @GaviSeth: filters, media etc.
“One of the challenges is how we make sure we optimize supply for all of the manufacturers."
@DrTedros @WHO @GaviSeth Committee on vaccine safety has reviewed available information on AZ vaccine and "has said that a causal relationship between the vaccine and the occurrence of blood clots with low platelets is plausible, but more investigation is required”, says @DrTedros.
@DrTedros @WHO @GaviSeth "All vaccines and medicines carry a risk of side effects. In this case, the risks of severe disease and death from #COVID19 are many times higher than the very small risks related to the vaccine”, says @DrTedros.
@DrTedros @WHO @GaviSeth Sinopharm and Sinovac shots are “in final stages of evaluation”, says Rogério Gaspar, director of regulation and prequalification. Technical advisory group is meeting April 26 “We expect that at least one of the two could make the time for that committee to be discussed there."
@DrTedros @WHO @GaviSeth “The trajectory of this pandemic around the world is going in the wrong direction”, says @mvankerkhove.
"We have had six weeks in a row, where there are increases in cases. Deaths are increasing as well. And we have tools right now that can prevent infections and can save lives”
@DrTedros @WHO @GaviSeth @mvankerkhove "We have to keep staying the course and do everything that we can”, says @mvankerkhove.
“We just really need to stop saying it's 'vaccine only’, it's 'vaccine and', and there's a lot of things that all of us can do right now."
@DrTedros @WHO @GaviSeth “We're now beginning to see supply constraints, not just of vaccines, but also of the goods that go into making vaccines”, says @GaviSeth: filters, media etc.
“One of the challenges is how we make sure we optimize supply for all of the manufacturers."
@DrTedros @WHO @GaviSeth Committee on vaccine safety has reviewed available information on AZ vaccine and "has said that a causal relationship between the vaccine and the occurrence of blood clots with low platelets is plausible, but more investigation is required”, says @DrTedros.
@DrTedros @WHO @GaviSeth "All vaccines and medicines carry a risk of side effects. In this case, the risks of severe disease and death from #COVID19 are many times higher than the very small risks related to the vaccine”, says @DrTedros.
@DrTedros @WHO @GaviSeth Sinopharm and Sinovac shots are “in final stages of evaluation”, says Rogério Gaspar, director of regulation and prequalification. Technical advisory group is meeting April 26 “We expect that at least one of the two could make the time for that committee to be discussed there."
@DrTedros @WHO @GaviSeth “The trajectory of this pandemic around the world is going in the wrong direction”, says @mvankerkhove.
"We have had six weeks in a row, where there are increases in cases. Deaths are increasing as well. And we have tools right now that can prevent infections and can save lives”
@DrTedros @WHO @GaviSeth @mvankerkhove "We have to keep staying the course and do everything that we can”, says @mvankerkhove.
“We just really need to stop saying it's 'vaccine only’, it's 'vaccine and', and there's a lot of things that all of us can do right now."

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More from @kakape

11 Apr
Like everything in this pandemic the science around the rare clotting disorder seen in AstraZeneca vaccinees has moved at an incredible pace. As the link has become clear, hints for a cause have emerged
Story with @GretchenVogel1 is here, thread to come:
sciencemag.org/news/2021/04/h…
@GretchenVogel1 As we explained in an earlier story, the combination of thromboses in unusual places and a low platelet count, quickly led researchers to think of HIT (heparin-induced thrombocytopenia), a rare side effect in people given the blood thinner heparin.

sciencemag.org/news/2021/03/r…
@GretchenVogel1 On Friday, reports from a group in Germany and one in Norway appeared in @NEJM. Both show that the patients have some of the hallmarks of HIT, like antibodies against platelet factor 4 and platelet activation.
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
Read 21 tweets
10 Apr
I‘ve had little time this past pandemic year to indulge in my passion for science around the color blue. But I did take some time this week to write about a cool paper describing a potential new blue food dye.
Story is here, quick thread on blue to come:

sciencemag.org/news/2021/04/p…
Yes, finding new blue food colorants is a whole thing.
The world mostly relies on brilliant blue, E131, and indigotine, E132. Both of these are synthetic, however, and there has been a push by consumers and companies for natural alternatives.
So the race has been on to find natural alternatives and I‘ve written about this before here:
There is one alternative that is now sometimes used: a crude extract of spirulina algae.
sciencemag.org/news/2019/05/m…
Read 13 tweets
7 Apr
"I want to start by stating that our safety committee the pharmacovigilance risk assessment committee of the European Medicines Agency has confirmed that the benefits of the AstraZeneca vaccine in preventing #COVID19 overall outweigh the risks of side effects”, says Emer Cooke.
“The PRAC, after a very in depth analysis, has concluded that the reported cases of unusual blood clotting following vaccination with the AstraZeneca vaccine should be listed as possible side effects of the vaccine”, says Cooke.
“Based on the current available evidence, specific risk factors such as age, gender, or previous medical history of clotting disorders have not been able to be confirmed as the rare events are seen in all ages, and in men and women”, says Cooke.
Read 19 tweets
6 Apr
15 Monate lang habe ich jetzt intensiv über diese Pandemie berichtet.
Ich habe mich in die Arbeit gestürzt, weil genau das hier mein Job ist. Aber auch weil es die Chance war etwas zu tun, sich nicht so nutzlos zu fühlen.
Ich habe mit Forscherinnen und Ärzten gesprochen, Artikel geschrieben, getwittert, einen Podcast gestartet, habe Panels moderiert, Pressekonferenzen gelauscht und Interviews gegeben.
Ich war häufig frustriert, gestresst, manchmal traurig.
Aber in dieser ganzen Zeit habe ich das schiere Ausmaß des Leids, das dieses winzige Virus verursacht hat, ziemlich erfolgreich von mir ferngehalten.
Drei. Millionen. Tote. Wie beginnt man das zu begreifen?
Read 11 tweets
2 Apr
My colleagues and I have decided to spend a few episodes of our @pandemiapodcast talking about the search for an HIV vaccine and parallels and differences with #covid19.
First episode (in German) here, a few thoughts (in English) to come:

viertausendhertz.de/pan21/
@pandemiapodcast It’s worth noting that we are coming up on 40 years since the first report appeared on what would turn into the devastating AIDS pandemic. On 5 June 1981, @CDCMMWR reported on 5 young men in Los Angeles with a rare pneumonia caused by a fungus, 2 had died

cdc.gov/mmwr/preview/m…
@pandemiapodcast @CDCMMWR One month later, there were 26 similar cases reported in @CDCMMWR (cssh.northeastern.edu/pandemic-teach…).
As Tony Fauci told us:
"At that point, it dawned upon me, we have a really serious problem. And this is very likely a new disease, likely a virus."
Read 10 tweets
31 Mar
“Our position has not changed”, says @EMA_News head Emer Cooke about AZ vaccine. “According to the current scientific knowledge, there is no evidence that would support restricting the use of this vaccine in any population."
@EMA_News I asked about numbers for Europe:
62 cases of cerebral venous thromboses so far, says Cooke with 9,2 million people vaccinated with AZ.
"If we look at the age-adjusted exposure, we calculate a risk of one per 100,000 in the under 60s."
@EMA_News CVST is much more common in women in general and about 2/3 of AZ vaccinees in Europe were women, says Peter Arlett. "this is why it is at this stage, difficult to disentangle the fact that there has been a preponderance of reports of this very rare potential side effect in women"
Read 8 tweets

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