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Dr Sumaiya Shaikh Profile picture
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12 Apr, 4 tweets, 2 min read
Sputnik V has 91.6% efficacy against COVID-19 & 100% against severe covid. 5 countries producing domestically incl. India & China. Aka GAM-COVID-Vac, it’s made of recombinant (S protein expressing gene of SARS-CoV2) adenovirus of 2 different serotypes (26 & 5)
Approved in India✅
PS it’s not Sputnik 5, it’s Sputnik V (the alphabet) probably a short to suggest it’s a viral vector vaccine. Sputnik 1 was also the first human-made satellite to orbit the earth.
Sputnik V is a double dose, 21 days apart vaccine. Both doses contain different serotypes of adenovirus. Single dose is not so effective (~85%). 2 way storage: 1. As a ready made water solution stored at -18•C OR 2. the freeze dried powder stored at 2-8•C & later mixed in water
Sputnik reported no serious adverse effects related to vaccination, except grade 1 events (flu, headache,etc). Serious effects reported in both placebo & vaccine groups. Total in phase ||| study ~20K. Data shows gender & ethnic distribution @TheLancet

thelancet.com/journals/lance…

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More from @Neurophysik

Dr Sumaiya Shaikh Profile picture
12 Apr
Lessons for professional & personal life. 🧵

For life during the COVID-19 2nd wave & beyond.
1. In medical education, teach an extra course called PPD (personal & professional development) which includes medical ethics, difficult conversations about end of life, breaking bad news to family, inequality in health, conflicts & global crisis,etc...
... in my medical school in Sydney, PPD was taught interactively for two hours, about 4 times a semester. They learn about conflicts as an issue of public health. (Looking at IMA’s response to Lancet). My class discussed Rohingya. In ‘end of life’ session, nearly everyone cried
Read 14 tweets
Dr Sumaiya Shaikh Profile picture
3 Mar
PSA for those who have registered/about to get COVID-19 vaccine via the Co-WIN app.
It is absolutely essential that those who have had immune suppressants like chemotherapy or during organ transplants, etc should make it known during the inoculation and avoid the #Covaxin jab.
Covaxin and other live attenuated vaccines should be avoided by:

1. HIV,
2. Cancer & chemotherapy,
3. Organ transplants
4. Taking steroids
5. Congenital immune deficiencies including complement deficiencies
6. phagocyte dysfunctions

Contd..
Read 5 tweets
Dr Sumaiya Shaikh Profile picture
24 Jan
COVAXIN Efficacy: A thread...

n0
Q1: Is there a method to hypothesise the efficacy of COVAXIN when no data has been released?
Q2: How is this efficacy enhanced & measured?
Q3: Why can’t COVAXIN be compared with other mRNA vaccines like COVISHIELD (AstraZeneca), ModeRNA and Pfizer?
n1
We know that COVAXIN, also known as BBV152, is based on a tested technology which inactivates or weakens the whole virus, in this case, SARS-CoV-2. NIV isolated the virus strain (NIV-2020-770) of the coronavirus from a COVID-19 patient and sequenced its genome.
n2 Schematic drawing of the 1D structure of coronavirus spike.
Read 26 tweets
Dr Sumaiya Shaikh Profile picture
23 Jan
The Lancet has NOT endorsed Covaxin. It has just published the phase I data -the preprint (non peer reviewed version) of which was available since last year. Good that @BharatBiotech published this data, but it does not mean it has a been cleared from the safety perspective.
Safety clearance requires testing in many many people of various groups. In this paper, 3 types different vaccines were tested in 100 people each and compared with 75 people of placebo.
In comparison, @pfizer released the data of its vaccine in the briefings with the @US_FDA as below
Read 5 tweets
Dr Sumaiya Shaikh Profile picture
3 Jan
My analysis of the paper released by #BharatBiotech researchers & the Press Statement by the Drugs Controller General of India (DCGI) on Restricted Emergency approval of 1out of 3 COVID-19 virus vaccine from Bharat Biotech: A thread...
1. PIB "The Phase III efficacy trial was initiated in India in 25,800 volunteers & till date, ~22,500 participants have been vaccinated across the country"

Fact check "A total of 25,800 subjects will be enrolled & randomized in a 1:1 ratio to receive BBV152B vaccine and control"
1. Fact check contd...

A 1:1 ratio means half of 25800 will be enrolled, of which only (almost) 12900 will be given BBV152B vaccine and the other 12900 will be given a placebo, i.e. Phosphate buffered saline PBS with Alum gel (without antigen)

Source: CTRI
Read 24 tweets
Dr Sumaiya Shaikh Profile picture
8 Jul 20
TW & thread: COVID-19, menstruation & depression

Gynaecologists, Obstetrics & women that have recovered from COVID-19:

(Or keen beaners of Covid-19)

Women, How were your menstrual cycles post COVID-19 recovery? Want to know what may have happened?

Read on... 1/n
So we know that SARS-COV2 affects a lot of organs in the body apart from the respiratory system. They infection is systemic after a point and the virus is found in many areas of the body including the brain, liver, gut, & the reproductive organs. But once the recovery is over..2n
What do we know about the after effects? A lot of people have reported generalised fatigue several weeks (6-7 or more) post recovery. Not just physical but mental fatigue. And that conversation about depression I had with @dhruv_rathee was never so timely. Everything hurts...3n
Read 20 tweets

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