“We have now seen seven consecutive weeks of increasing cases and four weeks of increasing deaths”, says @DrTedros at @WHO presser on #covid19. “Last week was the fourth highest number of cases in a single week so far."
@DrTedros @WHO "This is despite the fact that more than 780 million doses of vaccine have now been administered globally”, says @DrTedros.
"Make no mistake, vaccines are a vital and powerful tool, but they are not the only tool."
@DrTedros @WHO “Confusion, complacency and inconsistency in public health measures, and their application are driving transmission and costing lives”, says @DrTedros.
"It takes a consistent, coordinated and comprehensive approach."
@DrTedros @WHO “WHO does not want endless lockdowns”, says @drtedros. “The countries that have done best have taken a tailored, measured, agile and evidence-based combination of measures."
@DrTedros @WHO "We too want to see societies and economies reopening and travel and trade resuming”, says @drtedros.
"But right now, intensive care units in many countries are overflowing.
And people are dying.
And it is totally avoidable."
@DrTedros @WHO "This disease is not flu. Young, healthy people have died”, says @drtedros. "And we still don't fully understand the long term consequences of infection for those who survive.” He lists some long term symptoms incl. fatigue, brain fog, tremors, depression, anxiety, joint pain.
@DrTedros @WHO "With a concerted effort to apply public health measures, alongside equitable vaccination, we could bring this pandemic under control in months", says @drtedros. "Whether we do or not, comes down to the decisions and the actions that governments and individuals make every day."
@DrTedros @WHO WHO and partners are working to expand manufacturing capacity for vaccines/drugs in Africa and other regions, says @doctorsoumya. "This is something that will take some time” because it is not just about building physical infrastructure but training people, transferring know-how.
@DrTedros @WHO @doctorsoumya Q about mixing-and-matching vaccines.
“There are no data at this point on any mix and match regimens”, says @Kate_L_OBrien. "We really welcome studies that would look at mix and match regimen.” (Mentions the ongoing UK trial.)
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien Clinical endpoint of the UK trial mixing and matching AZ vaccine with mRNA vaccine is immunogenicity, says @doctorsoumya. Points out that it is crucial to define a correlate of protection to evaluate these studies and others going forward.
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien "COVAX facility has as of today, distributed just over 38.7 million doses”, says Bruce Aylward.
"The whole vaccine supply situation remains precarious and the challenge still because of such competing demands for these doses remains a very difficult one to manage."
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien "This is exactly the time where we need to double down on the non-pharmaceutical interventions, on masking and reducing transmission”, says @Kate_L_OBrien.
“We should be as diligent as ever, and assure that we're not releasing too early."
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien “We need headlines around these public health and social measures, we need headlines around the tools that we have right now that can prevent infections and save lives”, says @mvankerkhove.
"We are in a critical point of the pandemic right now."
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien @mvankerkhove “If you look on our website and you actually look at the epi curve and the trajectory of the pandemic right now, it is growing exponentially”, says @mvankerkhove.
"This is not the situation we want to be in 16 months into a pandemic, where we have proven control measures."
@DrTedros @WHO @doctorsoumya @Kate_L_OBrien @mvankerkhove Q about remdesivir
Final data on the drug from Solidarity trial (more than 4500 patients treated) is being analysed, says @doctorsoumya. “The data analysis is currently ongoing and we should be updating those results in the next few weeks."

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More from @kakape

13 Apr
“While these events are very rare, we’re recommending a pause in the use of the J&J #COVID19 vaccine in order to prepare the healthcare system to recognize and treat patients appropriately and to report severe events they may be seeing in people”, says @CDCgov’s Anne Schuchat.
@CDCgov Q how long the pause may be
“The timeframe will depend obviously on what we learn in the next few days. However, we expect it to be a matter of days for this pause”, says @DrWoodcockFDA.
@CDCgov @DrWoodcockFDA "The issue here with these types of blood clots, is that if one administers the standard treatments that we as doctors have learned to give for blood clots, one can actually cause tremendous harm or the outcome can be fatal”, says Peter Marks.
Read 9 tweets
13 Apr
I just don’t get it, @NateSilver538. I admire your work on polling and you clearly appreciate the complexity there.
You can argue about the FDA decision for sure, but pretending it is blindingly obvious that they are wrong, simply isn’t true or fair to this situation.
As so often in this pandemic, I agree with @angie_rasmussen here.
I don’t think vaccinated individuals need to lose sleep over this, but I certainly want people at the agency tasked with ensuring the safety of vaccines to lose a little sleep over this.
Another good voice of reason when it comes to vaccines is @nataliexdean
Read 4 tweets
13 Apr
US FDA is recommending a pause in the use of the J&J #covid19 vaccine while they investigate 6 reported cases of the kind of rare clotting disorder seen after AZ vaccine too.
Should not come as a huge surprise to those of you who have been following the reporting on this.
As @GretchenVogel1 and I wrote last week, EMA is already investigating this safety signal.
Given that this vaccine (like AZ one) too uses an adenovirus to deliver the genetic instructions for #SARSCoV2 spike protein, there were worries about this.

sciencemag.org/news/2021/04/h… Image
@GretchenVogel1 There will be a press conference at 10am ET that may have more information.
But for now, think of this as a cautious approach to a safety signal, similar to what, for instance, PEI in Germany did when reports of AZ side effects emerged almost exactly a month ago.
Read 4 tweets
13 Apr
Gerade etwas verdutzt festgestellt, dass wir @pandemiapodcast jetzt schon seit mehr als einem Jahr machen. Am 13.4.2020 kam unsere zweite Folge raus, in der wir über Ebola in Liberia sprechen.
Was war eure Lieblingsfolge? Was würdet ihr gern noch hören?

viertausendhertz.de/pan02/
Und unsere aktuelle Folge zur Situation auf den Intensivstationen liegt @nsemak, @SalmLaura und mir besondes am Herzen.
Falls ihr sie noch nicht gehört habt, hier entlang:
viertausendhertz.de/pan22/
Und an dieser Stelle etwas verspätet ein riesiges Dankeschön an alle, die uns im ersten Jahr unterstützt haben!
@pandemiapodcast ist ein Herzensprojekt, aber die Finanzierung ist nach wie vor schwierig und wir hätten es nicht bis hierhin geschafft ohne großartige Unterstützung:
Read 4 tweets
11 Apr
Like everything in this pandemic the science around the rare clotting disorder seen in AstraZeneca vaccinees has moved at an incredible pace. As the link has become clear, hints for a cause have emerged
Story with @GretchenVogel1 is here, thread to come:
sciencemag.org/news/2021/04/h…
@GretchenVogel1 As we explained in an earlier story, the combination of thromboses in unusual places and a low platelet count, quickly led researchers to think of HIT (heparin-induced thrombocytopenia), a rare side effect in people given the blood thinner heparin.

sciencemag.org/news/2021/03/r…
@GretchenVogel1 On Friday, reports from a group in Germany and one in Norway appeared in @NEJM. Both show that the patients have some of the hallmarks of HIT, like antibodies against platelet factor 4 and platelet activation.
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
Read 21 tweets
10 Apr
I‘ve had little time this past pandemic year to indulge in my passion for science around the color blue. But I did take some time this week to write about a cool paper describing a potential new blue food dye.
Story is here, quick thread on blue to come:

sciencemag.org/news/2021/04/p…
Yes, finding new blue food colorants is a whole thing.
The world mostly relies on brilliant blue, E131, and indigotine, E132. Both of these are synthetic, however, and there has been a push by consumers and companies for natural alternatives.
So the race has been on to find natural alternatives and I‘ve written about this before here:
There is one alternative that is now sometimes used: a crude extract of spirulina algae.
sciencemag.org/news/2019/05/m…
Read 17 tweets

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