Thread by @inabster

Amended mirrored thread gathering info on potential treatment of COVID-19 with Quercetin & Zinc.
Includes various studies, articles, anecdotal & empirical evidence to help establish a case for its potential anti-viral effects especially when taken early on -
@HighPeaks77 et al.

2. Current study by renowned Montreal Researchers in the potential treatment of #COVID19 with Quercetin:
mcgilltribune.com/sci-tech/montr…
- via @ClaraLago1 @Caradelevingne @taylorswift13 @rihanna @AbbyMartin @Polly_Boiko @TomCruise @scarletmonahan @inabster @WHO @NHSuk @UN @UNICEF

3. Study receives 1 million dollar donation to initiate trials in China:
ircm.qc.ca/en/news/lazari…

4. More press on the trial: macleans.ca/news/canada/a-…

5. Radio interview with the leading researchers, Dr Michel Chrétien and Dr Majambu Mbikay: cbc.ca/player/play/17…

6. Video interview on CBC News:

https://twitter.com/CBCNews/status/1233454888400670724

7. Further links to various studies dealing with the benefits of Quercetin & Zinc, especially their potential against diseases, bacteria & viruses.

8. Quercetin efficacy against SARS - Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003: Small Molecules Blocking Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells - jvi.asm.org/content/78/20/…

9. Study of Quercetin efficacy on Influenza A Virus:
ncbi.nlm.nih.gov/pmc/articles/P…

10. Study of Quercetin efficacy on Ebola:
aac.asm.org/content/60/9/5…

11. Study of Quercetin efficacy on Hepatitis C Virus:
nature.com/articles/srep3…

12. Study of Quercetin on Chronic inflammation & oxidative stress as a major cause of age-related diseases & cancer:
pubmed.ncbi.nlm.nih.gov/19149749/

13. Oncology Reports - Study on suppression of cancer cell growth & inducing cell death in Prostate cancer cells - Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms & clinical application potential (Review)
spandidos-publications.com/or/33/6/2659

14. Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways -
pubmed.ncbi.nlm.nih.gov/32174789/
- @meNabster

15. Here is other #Quercetin anti-cancer research on test tube and animal studies on liver, lung, breast, bladder, blood, colon, ovarian, lymphoid, and adrenal cancer cells:
A. ncbi.nlm.nih.gov/pubmed/28677813
B. ncbi.nlm.nih.gov/pubmed/28264020
C. ncbi.nlm.nih.gov/pubmed/24223637
- @meNabster

16. Here are Studies of some positive effects of #Quercetin on Alzheimer’s disease and Dementia:
A. ncbi.nlm.nih.gov/pubmed/26904161
B. ncbi.nlm.nih.gov/pubmed/25666032
- @meNabster @philomene1958

17. Here are some studies of the effects of #Quercetin on High blood pressure:
A. ncbi.nlm.nih.gov/pubmed/1206570…
B. ncbi.nlm.nih.gov/pubmed/8919657/
C. ncbi.nlm.nih.gov/pubmed/11325801

18. Studies on the effect of Quercetin on combatting aging:
A. ncbi.nlm.nih.gov/pubmed/28966753
B. ncbi.nlm.nih.gov/pubmed/29988130

19. Studies on the effects of #Quercetin to aid blood sugar levels in Diabetics:
A. ncbi.nlm.nih.gov/pubmed/30848564
B. ncbi.nlm.nih.gov/pubmed/30735748

20. Here is a study on the anti-inflammatory properties of Quercetin.
It is specifically important given the potential of inhibiting the high cytokine storm induced by #COVID19, causing major complications like bilateral interstitial pneumonia etc.
ncbi.nlm.nih.gov/pmc/articles/P…

21. Other study on anti inflammatory properties of Quercetin w/ inhibition of pro inflammatory cytokines: Flavonoid Quercetin Inhibits Proinflammatory Cytokine Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System cvi.asm.org/content/13/3/3…

22. In test-tube studies, #Quercetin reduced markers of inflammation in human cells, including the molecules tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). Here are two studies with regard to that:
A. ncbi.nlm.nih.gov/pubmed/20943792
B.

23. An 8-week study in 50 women with rheumatoid arthritis observed that participants who took 500 mg of #Quercetin experienced significantly reduced early-morning stiffness, morning pain, & after-activity pain. They had reduced markers of inflammation: pubmed.ncbi.nlm.nih.gov/27710596/

24. #Quercetin’s anti-inflammatory properties may provide allergy symptom relief. Studies found that it may block inflammatory enzymes & suppress inflammation-promoting chemicals, such as histamine.
A. ncbi.nlm.nih.gov/pubmed/27187333
B. ncbi.nlm.nih.gov/pubmed/18187018

25. Another study showed that taking #Quercetin supplements suppressed peanut-related anaphylactic reactions in mice:
pubmed.ncbi.nlm.nih.gov/20548131/

26. Here is a study with regard to #Quercetin’s efficacy in inhibiting the Zika virus:
biorxiv.org/content/10.110…

27. Possible effects of #Quercetin on SARS-COV-2, otherwise known as #COVID19.
There are various ways Quercetin may be effective in inhibiting the effects of the coronavirus.

28. 1) Blocking Entry of Virus. Supercomputer simulations by University of Tennessee & Oak Ridge National Labs to demonstrate which FDA approved chemical compounds may interfere with the coronavirus binding to cells. Out of 8000, Quercetin came in #5 - chemrxiv.org/articles/prepr…

28a. 1) Blocking Entry of Virus. Supercomputer simulations by University of Tennessee & Oak Ridge National Labs to demonstrate which FDA approved chemical compounds may interfere with the coronavirus binding to cells. Out of 8000, Quercetin came in #5 -

https://twitter.com/HighPeaks77/status/1249805652026896385

29. Recent study showed that SARS-COV-2 may infect lung cells via ACE receptors: biorxiv.org/content/10.110…
Quercetin has been shown to also inhibit ACE receptors in multiple in vitro and in vivo studies: scholar.google.com/scholar?q=Quer…

30. Yet more details on the mechanism of how Quercetin may block virus entry into cells. Here is the table from the Supercomputer simulation mentioned above:

https://twitter.com/taitlog/status/1241859474781917184

@taitlog says - Quercetin the double-edged sword against COVID-19?
1) Simulations show it binds the viral S-protein (potentially blocking entry)
2) Acts as a zinc ionophore (brings zinc into cell, blocking replication)
Still cheap & available. And we're hoarding toilet paper???

31. This seems to be the mechanism proposed by the Montreal researchers mentioned above. Here is a piece of the article mentioned above: mcgilltribune.com/sci-tech/montr…

32. 2) Quercetin acts as a Zinc Ionophore, allowing Zinc to pass the cell membrane and thereby inhibit the replication of the virus. Here is the study demonstrating this:
pubs.acs.org/doi/full/10.10…
though #Quercetin also has many other benefits as we've already shown so far...

33. This is essentially the same process behind chloroquine/Hydroxychloroquine as they are both Zinc Ionophores. This is one of the leading theories behind their efficacy as anti-viral drugs.
ncbi.nlm.nih.gov/pmc/articles/P…

34. Here is a great video demonstrating how chloroquine/Hydroxychloroquine work as zinc ionophores to inhibit virus replication:

35. As a side-note here are two recent documents showing the strong efficacy of Hydroxychloroquine & Zinc in fighting #COVID19.
A) docs.google.com/document/u/0/d…

36. B) Here is the second document on Hydroxychloroquine’s efficacy on treating COVID-19:
docs.google.com/document/d/1O6…

37. Zinc- The following is a study showing Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture:
ncbi.nlm.nih.gov/pmc/articles/P…

38. Here is a trial on the efficacy of Zinc on the common cold: ncbi.nlm.nih.gov/pubmed/15496046

39. More studies on Zinc’s anti viral properties:
A) ncbi.nlm.nih.gov/pubmed/17344507
B) ncbi.nlm.nih.gov/pubmed/16982486
C) ncbi.nlm.nih.gov/pubmed/23775705
D) ncbi.nlm.nih.gov/pubmed/19341987
E) ncbi.nlm.nih.gov/pubmed/15189121
F) ncbi.nlm.nih.gov/pubmed/18279051

40. . This is a very detailed explanation on the connection between chloroquine, Zinc & Quercetin & illustrates clearly how they share similar mechanisms.
dadamo.com/dangerous/2020…

41. 3) Another reason why #Quercetin may be effective at combating #COVID19 is due to the fact that it may inhibit the cytokine storm induced by the coronavirus:
ncbi.nlm.nih.gov/pmc/articles/P…

42. 4) Another potential Quercetin anti-Covid-19 mechanism:

https://mobile.twitter.com/taitlog/status/1248776042291933186

42a. Another potential role for (iso)quercetin in treating #COVIDー19 - where in severe patients there is microthrombosis in the lungs with elevated D-dimer, isoquercetin was shown to clinically decrease D-dimer in this study Onion
ncbi.nlm.nih.gov/pmc/articles/P… - credits @taitlog 😘

43. See this tweet as well: insight.jci.org/articles/view/…

https://mobile.twitter.com/gstanchev/status/1249793675401375745

43a. Could isoquercetin be administered as an adjunct therapy even for more severe C19 cases? This trial demonstrates 1000mg isoQ decreases D-dimmer by ~22%. It inhibits PDI activity and blocks platelet accumulation & fibrin generation.
Not much to lose.

And this tweet: credits @__ice9

https://mobile.twitter.com/__ice9/status/1249820862745894913

44. Human study at 1000mg of isoquercetin (much more bioavailable than ordinary quercetin). May have some limited anticoagulant effects.
More interestingly, the study found no apparent adverse effects for high-dose isoquercetin.
insight.jci.org/articles/view/…

Also #isoquercetin data & info credits @gstanchev @__ice9

45. Linking articles & videos related to #Quercetin’s potential to fight COVID-19.

46. Can quercetin help us to avoid the threat of coronavirus infection? | Journal Online
journal.com.ph/news/world/bre…

47. Quercetin can help to combat #COVID19 - regenexx.com/blog/coronavir…
- @meNabster

48. #COVID19: what treatments are being investigated? #Quercetin is more effective than cromolyn sodium in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans - bmj.com/content/368/bm…

49. Combating Covid-19 with Zinc & #Quercetin:

50. #Quercetin vs #CoVid19 (Powerful anti-viral properties of this unique nutrient):
thenutritionwatchdog.com/quercetin-vs-c…

51. Can #Quercetin Treat Coronavirus Infection? supplementclarity.com/does-quercetin…

52. Mast Cell Activation & Coronavirus: Is #Quercetin Effective Against #COVID19? - Mast cell stabilisers and covid-19 - via @TheBMA - bmj.com/content/370/bm…

53. Quercetin as Zinc Ionophore & #COVID19 Outpatient Management By DrBeen Medical Lectures:

54. MedCram Video Update #35- This was one of the first mentions on the potential of Quercetin to act as a Zinc Ionophore like Hydroxychloroquine to inhibit virus replication, thereby potentially acting as a treatment for SARS-COV-2/ #COVID19:

55. Eastern Virginia Medical School Critical Care #COVID19 Management Protocol & earlier treatment recommendation/ They recommend Quercetin 250mg-500mg each day.
evms.edu/media/evms_pub…

56. It also part of the daily regimen by Harvard Researcher, David Sinclair. blog.daveasprey.com/wp-content/upl…

57. Some more tweets for layperson reading on the supplements Quercetin, Zinc, Bromelain, etc benefits against #COVID19:

58. What is #Quercetin? Here is a great article on its nature: benefits, foods, dosage, possible side effects.
healthline.com/nutrition/quer…

59. What is Zinc: Everything You Need to Know -
healthline.com/nutrition/zinc

60. Bromelain: Dosage, Benefits, and Side Effects - healthline.com/health/bromela…

61. Why bromelain - An enzyme from Pineapple
renders #COVID19 spike ineffective, stopping it from infecting other cells!
Clinical trial to start soon with coronavirus patients in Australia to test the pineapple drug -
inqld.com.au/news/2020/08/1…
via @AgBioWorld @meNabster

62. Here is a new study in Turkey that will study the prophylaxis & treatment of Quercetin for #COVID19:
clinicaltrials.gov/ct2/show/NCT04…

63. Very interesting article:

https://mobile.twitter.com/KathyCo30202426/status/1258549870694023168

63a. Interesting read: ‘We’ve Cracked the COVID-19 Code.’ (And Why No One is Listening.) by Joyce Kamen link.medium.com/hqTLtteU35. #Quercetin, ascorbic acid, #Vitamin C, #Vitamin D, Zinc, #melatonin, corticosteroids earlier and for the May4 protocol: evms.edu/.../Marik-Covi…

64. New trial underway for Isoquercetin for high risk prevention in #COVID19:
sph.umich.edu/biostat/covid1…

65. New trial in Canada by Dr Michel Chretien’s team:
icav-citav.com/icav_news/isoq…

66. Another report where #Quercetin helped:

https://mobile.twitter.com/freedom9230/status/1271921239267979267

67. Terrific Paper!

https://mobile.twitter.com/sup_sam/status/1274014618730426368

Quercetin & Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) #Quercetin #COVID19 frontiersin.org/articles/10.33…
via @sup_sam @meNabster

67a. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) #Quercetin #Covid19 - credits @sup_sam
frontiersin.org/articles/10.33…

68. Also this thread - #COVIDー19 tips
by JoiningUnrelatedDots @Mareeswj

https://mobile.twitter.com/Mareeswj/status/1280597306895560704

69. Supported by evidence of significant clinical benefits doi.org/10.1016/j.jsbm… Over-the-Counter remedy for prevention & therapy
doi.org/10.3390/biomed…
Vitamin D & Quercetin inhibit viral entry & Vitamin D + QCT + Estradiol interfere w/ functions of 26/27 (96%) virus proteins

70. A path to clinical trial: Quercetin + Vitamin D + Estradiol alter expression of 244 of 332 (73%) SARS-CoV-2 targets in human cells, thus interfering with functions of 96% (26 of 27) SARS-CoV-2 proteins.
doi.org/10.3390/biomed…
TRIPARTITE COMBINATION FOR PANDEMIC MITIGATION

71. Another computer-aided molecular screening in Europe (alongside the one at UT/ORNL) in which #Quercetin also ranked highly.

https://twitter.com/Cran75H/status/1246515013315108864

via @aronro @Cran75H

71a. Supported by supercomputer MOGON II, this candidate compounds were predicted as presumable SARS-CoV-2 inhibitors.
Interestingly, high place is occupied by popular Procyanidins, Rutin (#Quercetin).
researchgate.net/publication/34…
Credit: @Cran75H
.@meNabster

72. Montreal Clinical Research Institute is seeking sites for Isoquercetin COVID-19 Clinical Trial ctontario.ca/covid-19-clini…
- credit Sam Sup @sup_sam
- via @meNabster

73. The spike protein of #SARSCoV2 is likely a basic secretagogue like the viral nucleocapsid protein. It triggers the Mas-related GPR X2 receptor on mast cells.
#Quercetin blocks the MRGPRX2 receptor and should be given w/ any vaccine. - by @dwmoskowitz

https://twitter.com/dwmoskowitz/status/1358119705857449984

74. COVID-19 Patient with Multifocal Pneumonia and Respiratory Difficulty Resolved Quickly: Possible Antiviral & Anti-Inflammatory Benefits of Quercinex (Nebulized Quercetin-NAC) as Adjuvant
More @ tinyurl.com/ydbe4vfo
- via @meNabster

So far so good, @jack of @Twitter aren't getting their spanners on this long list of evidence on benefits of #Quercetin & Zinc against #SARSCoV2 & also as a protocol to follow for possible vaccines' side-effects, + plenty of testimonials through other threads & @ScarofOdysseus.

Plenty of testimonials at the tail of this long thread mirrored from @HighPeaks77 & @ScarofOdysseus -

https://twitter.com/meNabster/status/1339718419487334407

- I might mirror testimonials separately on @inabster too later. You also tweeps who used Quercetin & Zinc, also maybe Niacin are welcome for your input.

@threadreaderapp please kindly unroll benefits of Quercetin, Zinc & other bioavailability cofactors in the treatment of #COVID19 along with safe & effective mRNA or otherwise vaccines 💨🌊🐳