This Cansion vaccine is intriguing. Like AZ, Sputnik, Janssen, it is an adenovirus vector vaccine. But it is given via inhalation - a little like nasal spray flu vaccines (although those are live attenuated virus vaccines).
1/7
1/7
https://twitter.com/hildabast/status/1382842523492646914
The link @hildabast provided is to the trials page. A previous paper is here: thelancet.com/journals/lance…
2/7
2/7
In theory at least, inhaled vaccines may, by virtue of the fact that they act directly on the respiratory mucosa, induce a better mucosal immunity (IgA etc) than system (eg IM) injection.
3/7
3/7
John Campbell @Johnincarlisle has an interesting hypothesis (which he makes a reasonable argument for) that IF the AZ and J&J/Janssen vaccines are associated with CVST and related clotting disorders, this may arise when they are inadvertently injected intravenously.
4/7
4/7
So he recommends aspirating (drawing back on the syringe plunger to check the tip of the needle isn't in a blood vessel) before injecting the vaccine, as we used to do when I first started giving IM injections and until (when did we change?).
5/7
5/7
Of course, if the vaccine is given by inhalation, there will be no possibility of intravenous injection; and if John's hypothesis is correct, no or less risk of these clotting disorders.
6/7
6/7
Whether this jokey/serious exchange on Twitter (@wyomingwormboy's question and @VirusesImmunity's response)
7/7
https://twitter.com/wyomingwormboy/status/1370209677384945665undermines John's hypothesis, I'm not sure.
7/7
@wyomingwormboy @VirusesImmunity Aargh! First tweet should have said CanSino. Not Cansion.
@wyomingwormboy @VirusesImmunity AND I forgot to include the link to @Johnincarlisle 's video in which he makes the argument for aspiration prior to vaccination.
• • •
Missing some Tweet in this thread? You can try to
force a refresh
