Thread by @TumorBoardTues

#PancChat #TumorBoardTuesday

💥A truly unique TBT w/ a hybrid🗣️on BRCA-mut Panc Ca with @letswinpc @drallysonocean & @TumorBoardTues

➡️Here is this week's Thursday Case🎀

👉👉And pick up your🆓#CME credit by answering 2 quick❓

Here is the post-test🔗
surveymonkey.com/r/GBYGYB2

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

We🗣️a lot about #PancreaticCancer including:
✅Delays to Dx
✅Choosing NOT to have chemo
✅Universal🧬testing
✅BRCA mut & PARP inh

We captured as much as we could in these two moments:
twitter.com/i/events/13838…

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

And this moment too:
twitter.com/i/events/13838…

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

One more editorial comment before diving into the wrap up.......

THANK YOU ALL for the support for @TumorBoardTues ‼️

After just 4 months, we reached our first 1000 followers😀
ton.twitter.com/1.1/ton/data/d…

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

@letswinpc and @drallysonocean asked how would we Tx a patient with recurrent, metastatic #PancreaticCancer

65% suggested treatment with FOLFIRINOX
(But maybe that's cuz they knew it was a BRCA case🕵️‍♂️)

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Many folks⚖️in on why a diagnosis of #PancreaticCancer is often delayed
@ConferenceArc @robertson_judym @heatherahannon @HPolymenis @HadderDamon

@drallysonocean summarized it best:

https://twitter.com/drallysonocean/status/1384659212601597952?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

👉We also🗣️about NON-chemo options that we👂a lot from patients

But some important feedback:
➡️some 'nonchemo' options are tougher to take than most chemo @ShaalanBeg
&
➡️Chemo can help!!! @MPishvaian

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Next, NGS🧬testing revealed a BRCA2 mutation

Everyone then📣that ALL PATIENTS WITH #PancreaticCancer should have germline & somatic🧬testing
@letswinpc @PanCAN @lustgartenfdn

https://twitter.com/pashtoonkasi/status/1384661300098240516?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

@drallysonocean posed the question - how would you next treat this patient (with a BRCA2 mutation), and there was a pretty even split:
(and THANK YOU that no one chose immunotherapy!!)

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Next our mini-tweetorials
(and as usual, I am not going to alter these masterpiece tweets):

Mini-Tweetorial 1:

https://twitter.com/letswinpc/status/1384661468335968256?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Mini-Tweetorial 2:

https://twitter.com/letswinpc/status/1384662101629808642?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Mini-Tweetorial 3:

https://twitter.com/letswinpc/status/1384662434993082369?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Mini-Tweetorial 4:

https://twitter.com/letswinpc/status/1384662640669208577?s=20

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

So the patient received a PARP inhibitor

Hats off to Ashworth and Lord for bring this all to💡

pubmed.ncbi.nlm.nih.gov/28302823/

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

But don't forget
✅Loss of heterozygosity is (likely) needed for synthetic lethality
✅And PARPi really don't benefit #PancreaticCancer patients whose disease has progressed on platinums!
pubmed.ncbi.nlm.nih.gov/30051098/

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

And do consider that PARP inhibitors, even though they are💊can definitely have serious side effects

Thanks @pashtoonkasi for👉us to this comprehensive review
thelancet.com/journals/lanon…

#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)

Thankfully the patient is doing well.

This was a tremendously invigorating discussion

➡️Please be sure to join us on May 4, 2021 when @loconte presents for us a case of a cholangiocarcinoma with an FGFR fusion😀

#PostTest Q1️⃣ #CME #TumorBoardTuesday

🧐BRCA1🧬& 2 mutations🧬(combined) occur in approximately what % of pancreatic cancers❓

👉🏼post test🔗: bit.ly/3xaIkXk

ALL🆓CME🔗: bit.ly/TBTxCME

#PancreaticCancer #PanCan #BRCA1 @MPishvaian @drallysonocean @letswinpc

#PostTest Q 2️⃣ #CME #TumorBoardTuesday

🧐BRCA1 🧬and 2 🧬are critical for what kind of DNA 🧬 damage repair❓:

👉🏼post test 🔗: bit.ly/3xaIkXk

ALL 🆓 🏆CME 🔗: bit.ly/TBTxCME

#PancreaticCancer #PanCan #BRCA1 @MPishvaian @drallysonocean @letswinpc