Thread by @TumorBoardTues

#TumorBoardTuesday
Thursday Case Wrap Up🎀
(Case from 02/09/21)

What a high level discussion on HER2+ gastroesophageal cancer led by @DocCatenacci

We captured as much as we could wrap our heads around in these moments:

twitter.com/i/moments/1358…

#TumorBoardTuesday
Thursday Case 🎀
(Case from 02/09/21)

Here is the second moment from @DocCatenacci

twitter.com/i/moments/1359…

#TumorBoardTuesday
Thursday Case 🎀
(Case from 02/09/21)

Earn your 🏆🆓CME credit!
✅Please don't forget to take the post-case questions:
integrityce.com/tbt2-9

⬇️⬇️The breakdown of our participants⬇️⬇️

#TumorBoardTuesday
Thursday Case🎀
(Case from 02/09/21)

Next @DocCatenacci challenged us:
❓What to use as second-line Tx for patients with HER2+ gastroesophageal cancer that progressed on trastuzumab-based therapy❓

🗝️And only 40 – 60% of GEA pts receive 2nd line Tx🗝️

#TumorBoardTuesday
Thursday Case🎀
(Case from 02/09/21)

⚡️Then had the case:
A pt with progressive dz after 12 mos of FOLFOX+trast
➡️The tumor was persistently HER2+ by IHC
🚫BUT ERBB2 was non-amplified by ctDNA NGS

@DocCatenacci posed 2 poll questions on the next Tx choice:

#TumorBoardTuesday
Thursday Case🎀
(Case from 02/09/21)

✅A LOT of side 🗣️ on maintenance 5FU/cape + trastuzumab
🗝️DROP the 5FU bolus #banthebolus

❓Do you drop or keep leucovorin if there is no 5FU bolus
➡️No consensus was reached
➡️Feel free to keep weighing in here

#TumorBoardTuesday
Thursday Case🎀
(Case from 02/09/21)

@DocCatenacci gave us such a high level tweetorial I couldn't do it justice by summarizing it.

⬇️⬇️Here is a link to his tweetorial thread⬇️⬇️
threadreaderapp.com/thread/1359313…

#TumorBoardTuesday
Thursday Case🎀
(Case from 02/09/21)

🗝️points:
✅RETEST for HER2 status (ctDNA is a great option)
If HER2⛔️(&CPS=0) ➡️ chemo combo
🌈(pac+ram)
thelancet.com/journals/lanon…

Or the📢Catenacci regimen (FOLFIRI + ram)💥
ascopubs.org/doi/abs/10.120…
pubmed.ncbi.nlm.nih.gov/30470690/