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Hannah Davis 🦈 Profile picture
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27 Apr, 4 tweets, 3 min read
Antibody testing to diagnose #LongCOVID disenfranchises women!

1) Males are 4x more likely to retain antibodies
2) 36% of females lost antibodies by 3-6 months vs 8% males
3) 80% of those who lose antibodies are female
4) Men have higher antibody levels

meddocsonline.org/annals-of-epid…
Additionally, common COVID antibody tests, including Abbott, were validated against hospitalized patients & used too high a threshold. This results in 10-30% of "mild" infections accidentally being classified as negative:

bmcinfectdis.biomedcentral.com/articles/10.11… #LongCOVID
And overall, antibody tests are most sensitive on middle-aged men, especially patients between age 40-59:

jamanetwork.com/journals/jaman… #LongCovid
@EricTopol @Dr2NisreenAlwan @ErinSandersNP a good resource!

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More from @ahandvanish

Hannah Davis 🦈 Profile picture
28 Apr
Happening now!!!
from the CDC: "Clinical guidance is also informed by patient groups with whom we share the information" - that's @patientled and @itsbodypolitic!
from @NIHDirector - "11-15% of kids can end up with #LongCOVID, which can be devastating in terms of things like school performance. This is separate from MIS-C"
Read 68 tweets
Hannah Davis 🦈 Profile picture
22 Apr
Body Politic (@itsbodypolitic) has released an open letter to the NIH on how the $1.15 billion in #LongCOVID funding should be spent.

wearebodypolitic.com/bodytype/2021/… 1/
"Researchers with decades of post-infection experience need to be at the forefront of the Long COVID research agenda, or we risk delaying our understanding and treatment of this illness." 2/
"ME/CFS researchers have made substantial discoveries in the areas of metabolic profiling, neuroimmunology, metabolomics & proteomics, impaired endothelial function in POTS, mitochondrial fragmentation, antiviral & metabolic phenotypes, hypoperfusion & cerebral blood flow..." 3/
Read 4 tweets
Hannah Davis 🦈 Profile picture
14 Apr
This is a *wild* but must-read story: a professor of psychology tries to convince insurance companies that #LongCOVID is not real, but that it was made up by @GeorgeMonbiot who wrote a January 2021 column on it.

1/
The catch: this psychologist has been doing this for every post-viral illness (like ME), because he has made a career off Cognitive Behavior Therapy as a "cure" - and continued to push it even after it was rated "low-very low" scientific quality. 2/
A entire special issue in the Journal of Health Psychology noted that this guy & his team showed a "consistent pattern of resistance", were "unwilling to enter into the spirit of scientific debate", & "acted with a sense of entitlement not to have to respond to criticism." 3/
Read 6 tweets
Hannah Davis 🦈 Profile picture
6 Apr
New data from the Office of National Statistics in the UK, which has been doing some of the best #LongCOVID prevalence work.

The previous estimate of 10% still sick at 12 weeks is updated to 13.7%. Instead of 1 in 10, now 1 in 7.

This includes kids, so is higher in adults. 1/
For the first time, they've released age-based prevalence numbers for the % of people still sick at 12 weeks. People (with PCR+ tests) still sick with #LongCOVID at 12 weeks, by age:

2-11: 7.4%
12-16: 8.2%
17-24: 11.5%
25-34: 18.2%
35-49: 16.1%
50-69: 16.4%
70+: 11.2%

2/
Notably, like other longitudinal studies, there's only a small percentage point difference between men & women: of those who test positive, 12.7% of males, 14.7% of females will be sick with #LongCOVID at 12 weeks.

Of all the age groups, age 25-34 is most affected at 18.2%.

3/
Read 4 tweets
Hannah Davis 🦈 Profile picture
6 Apr
Considering #LongCOVID (and ME) to be an immune-modulated traumatic brain injury akin to a concussion: a thread of papers. 1/
"Bridge between neuroimmunity and traumatic brain injury":
2/
"Emerging Roles for the Immune System in Traumatic Brain Injury" 3/

Read 9 tweets
Hannah Davis 🦈 Profile picture
30 Mar
This new paper on 323 PCR positive #longhaulers containing a really crucial finding:

Low IgG levels in the acute phase were associated with persistent symptoms 7 months later! #LongCOVID 1/

medrxiv.org/content/10.110…
I do think there is mounting evidence that people with #LongCOVID have disproportionately low antibody levels, and that might be key to understanding the illness. It's also a crucial reason why people without antibodies need to be included in #LongCOVID research. 2/
The big downside of this paper is they only asked about 9 symptoms, none of which were neurological (like sensorimotor issues, "brain fog") except headache. Of those 9, they found that diarrhea or loss of smell in the acute phase were predictive of #LongCOVID at 7 months. 3/
Read 4 tweets

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