I develop fixations in my studies. I develop fixations on elements that present promise in connecting dots. It's all one big puzzle, and my goal is to make the pieces fit. I can't do it without developing these fixations.

#SARSCoV2, microclots, infarcts, multi-organ damage.
#SARSCoV2 inhibits Type-1 interferon (IFN). This is its evolutionary advantage over its predecessor SARSCoV, & likely the reason behind the asymptomatic phenomenon, since IFN ➡️ immune activation, inflammation, fever ➡️ symptoms.

This is what makes #COVID19 special. Image
We also know that IFN is critical in facilitating a switch from innate immunity (nonspecific defenses like neutrophil NETosis & platelet-induced coagulation) to adaptive immunity (highly specific defenses involving T/B cells & antibody production). Image
If Type-1 IFN is inhibited, how much does that inhibit, or delay, adaptive immunity (T cell, B cell activation, antibodies)? How much does that then skew the share of the battle back onto primitive defenses like innate immunity + complement (➡️⬆️ immunothrombosis/microclotting)? Image
The over-reliance on immunothrombosis/microclotting during an acute #COVID19 infection is evident and well-documented. Image
This likely explains why #SARSCoV2 induces 9x more microclots than #influenza.

The outcome of pervasive microclotting, visualized;

Microvascular thrombosis in 85% of patients with severe #COVID19, w/ 31% exhibiting completely stagnated capillaries. Small sample size in this study of sublingual tissue. Image
Pervasive microclotting has consequences for organs across the body because it disrupts blood-flow dynamics, and thereby risks oxygen-deprivation-related damage.

The consequences therein on the brain intrigue me most of all.

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More from @FizeekBio

2 May
"Physicians like disease & injury to be visible, if they are going to accept it as real."

I'm going to start w/ a focus on #MECFS, and then round out this tweet-thread w/ a segway onto why all this matters for #longcovid, too. This chronology is poetically fitting, at any rate.
We know by now that #MECFS brains are generally replete w/ neuroinflammation. PET & MRSt scans demonstrate this readily and consistently. ImageImageImage
We know by now that metabolites, like lactate, choline-containing compounds, myo-inositol, & N-acetylaspartate, are considerably altered in #MECFS brains, and this is readily demonstrated via MRS scanning. Image
Read 12 tweets
15 Oct 20
The immune-response and #COVID19. The "Wack-a-Mole" theory.

This is going to be heavy, and technical at points. But it's important that I regurgitate my thoughts. This is my Eureka moment. #SARS_CoV_2
#COVID degrades the epithelial cells of the lungs, and begins infiltrating therein via the epithelial cells of the underlying vasculature. Image
The immune system reacts by tipping the balance towards clotting (releasing factors that make the blood more “sticky” and conducive to clotting), in effort to stall the intruders right in their point of entry before entering the wider circulatory system.
Read 16 tweets

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