Thread by @Dan_Wyke

🧵1/ Every day this month I'll add a different piece of ME/CFS biomedical research to this tweet so that by the end of #MEAwarenessMonth there'll be a nice long thread of biomedical research papers to keep or share. First up:
…nslational-medicine.biomedcentral.com/articles/10.11… #MECFS #pwME

🧵2/ 'Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations', Maureen R. Hanson et al #MEAwarenessMonth #pwME #MECFS #research #MedTwitter #MedEd
ncbi.nlm.nih.gov/pmc/articles/P…

🧵3/ 'Distinct plasma immune signatures in ME/CFS are present early in the course of illness', Mady Hornig et al #MEAwarenessMonth #pwME #MECFS #researchpaper #MedTwitter
advances.sciencemag.org/content/1/1/e1…

🧵4/ 'Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)', G. Morris & M. Maes #MECFS #pwME #research
#MEAwarenessMonth #MedTwitter
ncbi.nlm.nih.gov/pmc/articles/P…

🧵5/ 'Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections', Luis Nacul et al
pubmed.ncbi.nlm.nih.gov/31824487/
#MECFS #MEAwarenessMonth #pwME #research #MedTwitter

🧵6/ 'Chronic fatigue syndrome from vagus nerve infection: a psychoneuroimmunological hypothesis', M. VanElzakker #MECFS #MEAwarenessMonth #MedTwitter #pwME pubmed.ncbi.nlm.nih.gov/23790471/

🧵7/ 'Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome', Fluge & Mella et al #MEAwarenessMonth #MECFS #MedTwitter #pwME #MedEd insight.jci.org/articles/view/…

🧵8/ 'The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function', Cara Tomas et al journals.plos.org/plosone/articl… #MECFS #pwME #MEAwarenessMonth #MedTwitter #research #MedEd #MyalgicE #MyalgicEncephalomyelitis

🧵9/ 'A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis', Barnden et al #MECFS #MEAwarenessMonth #MedTwitter #MedEd #pwME #Researchpapers #MyalgicE #NEISvoid ncbi.nlm.nih.gov/pmc/articles/P…

🧵10/ 'Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study', Nakatomi et al #MEawarenessweek #MECFS #pwME #MyalgicEncephalomyelitis #MedTwitter #MedEd #MyalgicE jnm.snmjournals.org/content/55/6/9…

🧵11/ 'A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)', R. Davis et al #MEAwarenessWeek #MECFS #MEAwarenessWeek2021 #pwME
#ResearchEd #MedTwitter #MedEd pnas.org/content/116/21…

🧵12/ 'Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis', Sonya Marshall-Gradisnik et al #MECFS
#MEAwarenessDay #MedTwitter
#MEAwarenessWeek #MEAwareness
#MEAWarenessWeek2021 #pwME
…nslational-medicine.biomedcentral.com/articles/10.11…

🧵13/ 'EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients- A case control study', A. Komaroff et al #MECFS #MEAwarenessWeek #MedTwitter #MedEd #pwME #MyalgicE #research bmcneurol.biomedcentral.com/articles/10.11…

🧵14/ 'Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome', D. Missailidis et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MECFSAwarenessWeek #MedTwitter #MedEd #pwME #MyalgicE #research

🧵 15/ 'Evidence of widespread metabolite abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Assessment with whole-brain Magnetic Resonance Spectroscopy', J. Younger et al #MECFS #MEAwarenessWeek #MedTwitter #MyalgicEncephalomyelitis ncbi.nlm.nih.gov/pmc/articles/P…

🧵 16/ 'Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology', Jarred Younger et al #MECFS #MEAwarenessWeek #pwME
#MyalgicEncephalomyelitis …nslational-medicine.biomedcentral.com/articles/10.11…

🧵 17/ 'Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome', A. Ghali et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MEAwareness #MedTwitter #pwME

🧵 18/ 'Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography', F. C. Visser et al #MEAwareness #MECFS
#MedTwitter #MedEd #pwME
ncbi.nlm.nih.gov/pmc/articles/P…

🧵 19/ 'Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome', M. Hanson et al #MECFS
#MEAwarenessMonth #MedTwitter
microbiomejournal.biomedcentral.com/articles/10.11…

🧵 20/ 'Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome', M. Hanson et al …nslational-medicine.biomedcentral.com/articles/10.11… #MECFS #pwME #MEAwarenessMonth #MedTwitter

🧵 21/ 'Cytokine networks analysis uncovers further differences between those who develop myalgic encephalomyelitis/chronic fatigue syndrome following infectious mononucleosis', Leonard A. Jason et al
tandfonline.com/doi/abs/10.108… #MECFS #pwME #MyalgicEncephalomyelitis #MedEd

🧵 22/ 'Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients', F. Westermeier et al #MECFS #pwME #MedTwitter #MyalgicE #MEAwarenessMonth nature.com/articles/s4159…

🧵 23/ 'Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome', G. Urbanski et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MyalgicEncephalomyelitis #MedEd #MedTwitter #pwME #MyalgicE

🧵 24/ 'Substrate utilisation of cultured skeletal muscle cells in patients with CFS', Cara Tomas et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #pwME #MyalgicEncephalomyelitis

🧵 25/ 'Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology', M. Hanson et al #MECFS #pwME mdpi.com/2218-1989/8/4/…

🧵 26/ 'Metabolic features of chronic fatigue syndrome', Robert K. Naviaux et al #MECFS #meawarenesshour #pwME
pnas.org/content/113/37…

🧵 27/ 'Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome', R. Davis et al #MECFS #pwME #MedTwitter content.iospress.com/articles/clini…

🧵 28/ 'Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids', M. Hanson et al mdpi.com/2218-1989/10/1… #MECFS #pwME #MedTwitter