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Dan Wyke 🦠➡️🧠🔥 Profile picture
@Dan_Wyke
May 1, 2021 • 28 tweets • 36 min read • Read on X
🧵1/ Every day this month I'll add a different piece of ME/CFS biomedical research to this tweet so that by the end of #MEAwarenessMonth there'll be a nice long thread of biomedical research papers to keep or share. First up:
…nslational-medicine.biomedcentral.com/articles/10.11… #MECFS #pwME
🧵2/ 'Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations', Maureen R. Hanson et al #MEAwarenessMonth #pwME #MECFS #research #MedTwitter #MedEd
ncbi.nlm.nih.gov/pmc/articles/P…
🧵3/ 'Distinct plasma immune signatures in ME/CFS are present early in the course of illness', Mady Hornig et al #MEAwarenessMonth #pwME #MECFS #researchpaper #MedTwitter
advances.sciencemag.org/content/1/1/e1…
🧵4/ 'Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)', G. Morris & M. Maes #MECFS #pwME #research
#MEAwarenessMonth #MedTwitter
ncbi.nlm.nih.gov/pmc/articles/P…
🧵5/ 'Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections', Luis Nacul et al
pubmed.ncbi.nlm.nih.gov/31824487/
#MECFS #MEAwarenessMonth #pwME #research #MedTwitter
🧵6/ 'Chronic fatigue syndrome from vagus nerve infection: a psychoneuroimmunological hypothesis', M. VanElzakker #MECFS #MEAwarenessMonth #MedTwitter #pwME pubmed.ncbi.nlm.nih.gov/23790471/
🧵7/ 'Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome', Fluge & Mella et al #MEAwarenessMonth #MECFS #MedTwitter #pwME #MedEd insight.jci.org/articles/view/…
🧵8/ 'The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function', Cara Tomas et al journals.plos.org/plosone/articl… #MECFS #pwME #MEAwarenessMonth #MedTwitter #research #MedEd #MyalgicE #MyalgicEncephalomyelitis
🧵9/ 'A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis', Barnden et al #MECFS #MEAwarenessMonth #MedTwitter #MedEd #pwME #Researchpapers #MyalgicE #NEISvoid ncbi.nlm.nih.gov/pmc/articles/P…
🧵10/ 'Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study', Nakatomi et al #MEawarenessweek #MECFS #pwME #MyalgicEncephalomyelitis #MedTwitter #MedEd #MyalgicE jnm.snmjournals.org/content/55/6/9…
🧵11/ 'A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)', R. Davis et al #MEAwarenessWeek #MECFS #MEAwarenessWeek2021 #pwME
#ResearchEd #MedTwitter #MedEd pnas.org/content/116/21…
🧵12/ 'Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis', Sonya Marshall-Gradisnik et al #MECFS
#MEAwarenessDay #MedTwitter
#MEAwarenessWeek #MEAwareness
#MEAWarenessWeek2021 #pwME
…nslational-medicine.biomedcentral.com/articles/10.11…
🧵13/ 'EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients- A case control study', A. Komaroff et al #MECFS #MEAwarenessWeek #MedTwitter #MedEd #pwME #MyalgicE #research bmcneurol.biomedcentral.com/articles/10.11…
🧵14/ 'Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome', D. Missailidis et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MECFSAwarenessWeek #MedTwitter #MedEd #pwME #MyalgicE #research
🧵 15/ 'Evidence of widespread metabolite abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Assessment with whole-brain Magnetic Resonance Spectroscopy', J. Younger et al #MECFS #MEAwarenessWeek #MedTwitter #MyalgicEncephalomyelitis ncbi.nlm.nih.gov/pmc/articles/P…
🧵 16/ 'Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology', Jarred Younger et al #MECFS #MEAwarenessWeek #pwME
#MyalgicEncephalomyelitis …nslational-medicine.biomedcentral.com/articles/10.11…
🧵 17/ 'Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome', A. Ghali et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MEAwareness #MedTwitter #pwME
🧵 18/ 'Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography', F. C. Visser et al #MEAwareness #MECFS
#MedTwitter #MedEd #pwME
ncbi.nlm.nih.gov/pmc/articles/P…
🧵 19/ 'Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome', M. Hanson et al #MECFS
#MEAwarenessMonth #MedTwitter
microbiomejournal.biomedcentral.com/articles/10.11…
🧵 20/ 'Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome', M. Hanson et al …nslational-medicine.biomedcentral.com/articles/10.11… #MECFS #pwME #MEAwarenessMonth #MedTwitter
🧵 21/ 'Cytokine networks analysis uncovers further differences between those who develop myalgic encephalomyelitis/chronic fatigue syndrome following infectious mononucleosis', Leonard A. Jason et al
tandfonline.com/doi/abs/10.108… #MECFS #pwME #MyalgicEncephalomyelitis #MedEd
🧵 22/ 'Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients', F. Westermeier et al #MECFS #pwME #MedTwitter #MyalgicE #MEAwarenessMonth nature.com/articles/s4159…
🧵 23/ 'Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome', G. Urbanski et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #MyalgicEncephalomyelitis #MedEd #MedTwitter #pwME #MyalgicE
🧵 24/ 'Substrate utilisation of cultured skeletal muscle cells in patients with CFS', Cara Tomas et al ncbi.nlm.nih.gov/pmc/articles/P… #MECFS #pwME #MyalgicEncephalomyelitis
🧵 25/ 'Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology', M. Hanson et al #MECFS #pwME mdpi.com/2218-1989/8/4/…
🧵 26/ 'Metabolic features of chronic fatigue syndrome', Robert K. Naviaux et al #MECFS #meawarenesshour #pwME
pnas.org/content/113/37…
🧵 27/ 'Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome', R. Davis et al #MECFS #pwME #MedTwitter content.iospress.com/articles/clini…
🧵 28/ 'Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids', M. Hanson et al mdpi.com/2218-1989/10/1… #MECFS #pwME #MedTwitter

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More from @Dan_Wyke

Dan Wyke 🦠➡️🧠🔥 Profile picture
Apr 13
Short 🧵

The medical community is failing #pwME badly right now. From GPs who deny patients medication for treatable symptoms to consultants who deny appropriate feeding arrangements for severely ill patients in hospital. 1/4 #MECFS #MyalgicEncephalomyelitis
Change is being blocked by bad faith actors who occupy positions of strategic importance in the medical hierarchy. The new NICE guidelines only seem to have reinforced their determination to retain the fallacious biopsychosocial model of #MECFS in the healthcare system. 2/4
This is undoubtedly a low point for the #MECFS patient community. Even somewhat better media coverage hasn't budged the dial. Ideally we would take visible direct action, but since that isn't possible, we must continue to speak out against the prejudice and maltreatment. 3/4
Read 4 tweets
Dan Wyke 🦠➡️🧠🔥 Profile picture
Feb 21
The long-awaited NIH Intramural Study of ME/CFS, led by Avindra Nath, has finally been published in full.

🧵 "Considering all the data together, Post-infectious ME/CFS (PI-ME/CFS) appears to be a centrally mediated disorder." 1/
nature.com/articles/s4146…


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"We posit this hypothetical mechanism of how an infection can create a cascade of physiological alterations that lead to the PI-ME/CFS phenotype. Exposure to an infection leads to concomitant immune dysfunction and changes in microbial composition." 2/
"These immune and microbial alterations impact the central nervous system, leading to decreased concentrations of metabolites, including glutamate, tryptophan, spermidine, citrate, and the metabolites of dopamine (DOPAC) and norepinephrine (DHPG)." 3/
Read 12 tweets
Dan Wyke 🦠➡️🧠🔥 Profile picture
Jul 17, 2022
Nath's back, finding a chronically activated immune response causing neuronal injury in the brains of #pwLC. It explains why it's taken him forever to publish his big #MECFS study, but the good/bad news is he thinks the same thing's happening in #pwME. 1/4 healthrising.org/blog/2022/07/1…
This looks very similar to what Komaroff et al suggested was happening in #MECFS 30 years ago: "patients may have been experiencing a chronic, immunologically mediated inflammatory process of the central nervous system." 2/4
pubmed.ncbi.nlm.nih.gov/1309285/
Nath also found the same widespread punctate hyperintensities in the microvasculature of brains which first started showing up in MRI scans of #pwME in the 80s (see J. Goldstein) and were routinely dismissed by neurologists as insignificant. 3/4 healthrising.org/blog/2021/01/2…
Read 4 tweets
Dan Wyke 🦠➡️🧠🔥 Profile picture
Jun 24, 2022
🧵 With poliomyelitis emerging as another Brexit benefit, it's worth restating, for people who are new to the study of infectious diseases, that the history and aetiology of #MyalgicEncephalomyelitis (ME) are inextricably linked to polioviruses. 1/
The viruses which cause polio belong to the Enterovirus family of viruses. Enteroviruses typically infect the gastrointestinal tract, sometimes spreading to the central nervous system. 71 human EV serotypes have been identified but more than 100 are thought to exist. 2/
Polio was originally thought to be caused solely by three enteroviruses - polio 1, 2, and 3, included in the Salk (1955) + Sabin (1960) immunisations. Since then at least 25 EVs capable of causing paralytic polio have been identified. No vaccine has been developed for these. 3/
Read 20 tweets
Dan Wyke 🦠➡️🧠🔥 Profile picture
Feb 28, 2022
🧵Long Covid research is advancing at an incredible rate. It's taken LC researchers less than 2 years to reach a point it's taken #MECFS researchers decades to get to - a reminder how quickly progress can be made when enough money/resources are dedicated to solving a problem.1/10
Good news for pwLC but it's not clear how pwME will benefit from this progress. Despite growing recognition that the two conditions share many similarities, not all LC research acknowledges the relationship between LC and ME/CFS, or even references earlier ME/CFS research. 2/10
Some LC papers are reproducing earlier ME/CFS findings which weren't replicated (due to funding) + were ignored by the med profession. Other LC papers show findings which have been hypothesised by ME/CFS researchers but not validated, again due to insufficient funding. 3/10
Read 10 tweets
Dan Wyke 🦠➡️🧠🔥 Profile picture
Oct 24, 2020
The British Association for CFS/ME (BACME) has very little credibility in the eyes of UK ME/CFS patients. The NHS clinics who its members run have been delivering harmful and inappropriate treatments (GET/CBT), with no system in place for reporting harm, for years. 1/ #MECFS
Now, just weeks before NICE releases the draft of its ME/CFS guidelines review, BACME puts out an announcement purporting to reject the biopsychosocial view of ME/CFS and offering a tweaked version of its main treatment (graded exercise therapy) to minimize its culpability. 2/
If BACME is sincere about having seen the error of its ways, one wonders why these changes couldn't have happened much sooner? The suspicion is, BACME either already knows what the NICE draft contains, or is taking an educated guess at its contents... 3/
Read 4 tweets

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