Thread by @ccmb_csir

Delve into the world of bacteria with the latest paper from Manjula Reddy's lab. They show a novel enzyme that modulates the molecular linkages in bacterial cell-walls.
pnas.org/content/118/19…
@CSIR_IND @PNASNews @Raj_with_sci @pavan_kumarch
Details follow
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Bacteria have a protective cell-wall around them. It contains an exoskeleton of peptidoglycan. In a big family of bacteria, called the gram-negative bacteria, this is covered by another layer - the outer membrane.
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In some bacteria, an abundantly found lipoprotein Lpp staples the peptidoglycan with the outer membrane. This study finds a novel hydrolytic enzyme that cleaves Lpp from the peptidoglycan.
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This study deepens our understanding of bacterial cell biology by addressing how outer membrane-peptidoglycan linkages are modulated. Unraveling novel enzymes and mechanisms open up newer targets for antimicrobial development - a necessity for the more silent #AMR pandemic.
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