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May 11, 2021 7 tweets 7 min read Read on X
THREAD - What if we could track and record repeat Adverse Drug Events? 🤔 💊

1/6: Register for our May 12 #BestEvidence webinar, as @corinne_hohl talks about Assessing the Impact of Information Continuity on Health Outcomes: bit.ly/3ap4FGO #MedEd
2/6: Why do Adverse Drug Events (ADEs) matter?

Each year in British Columbia, ADEs account for:
👉240,000 emergency dept (ED) visits
👉480,000 days in hospital
👉approx. 1 in 9 adult ED visits

More here: bit.ly/2Q7UGi8
#drugsafety #ptsafety #MedEd
3/6: In Canada, adverse drug events 💊 cause or contribute to almost 2⃣million emergency department visits annually 😯 🆘

See publication list here: actionade.org/referenced-art…

#MedEd #ptsafety #prescribing
4/6: Yet, possibly fewer than5⃣% of adverse drug events are reported to oversight bodies, so you might ask,” Why don’t Clinicians Report Adverse Drug Events?”

It’s a good❓and Dr. Hohl has some answers here: publichealth.jmir.org/2018/1/e21/

#drugsafety #MedEd #ptsafety
5/6: At least 33% of preventable adverse drug events requiring a hospital visit are repeat events? 😯💊🩺

These could be prevented with more effective ways of communicating relevant adverse drug event information: cmajopen.ca/content/7/3/E4…

#MedEd #drugsafety #prescribing
6/6: Dr. Corinne Hohl’s ActionADE project:

A provincial initiative to improve adverse drug event reporting + integrate these data into electronic medical records for better communication and better patient safety 👩‍⚕️💊 👪

More here: actionade.org

#MedEd #ptsafety
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More from @Drug_Evidence

Oct 10
🧵Safe diabetes treatment for older adults
👉🏽

1/ Risks of harms from side effects

⚠️For diabetes meds, low blood sugar is one of the most important side effects
⚠️Sulfonylureas & insulins are the drugs most likely to cause low blood sugar

#ptsafety #T2DM ti.ubc.ca/letter151Image
2/ Isn’t low A1c always good?

Trials w/ tens of thousands of pts looked at effects of achieving A1c < 7% for older ppl & found:

❌ No benefit to A1c < 7%, compared w/ more relaxed value of 7.5-8%
⚠️ A1c < 7% raises chance of dangerously low blood sugar

ti.ubc.ca/letter151Image
3/ What glycemic target to choose for older adults?

@ChooseWiselyCA provides the following reasonable glycemic 🎯:

🟢Healthy older ppl w/ long life expectancy: 7-7.5%
🟡Moderate comorbidity, life expectancy <10 yr: 7.5-8%
🔴Multiple morbidities, shorter life expectancy: 8-8.5% Image
Read 8 tweets
Nov 30, 2022
🧵 How well do you know your dopamine antagonists? 💊💊

1/ Using these drugs safely requires that clinicians & patients appreciate their important #AdverseEffects, which are not always well understood

👉🏽ti.ubc.ca/letter139

#MedEd #prescribing #deprescribing #medsafety
2/ #AdverseEffects may include:

⚠️ Drug-induced #Parkinsonism
-↘️ or slowed movements, rigidity/tremor/unsteadiness, facial expression loss

⚠️ #Akathisia
-intense internal restlessness or desire to move (which may be mistaken for anxiety)

👉🏽Pt videos: ti.ubc.ca/letter139
3/ #AdverseEffects may include:

⚠️Acute dystonic reaction
-sudden, involuntary, often painful muscle spasm

⚠️Dyskinesia
-repetitive, involuntary movements...can be associated with cognitive decline

👉🏽Pt experience videos: ti.ubc.ca/letter139

#MedEd #ptsafety #drugsafety
Read 7 tweets
Nov 3, 2022
🧵 Reducing unnecessary use of proton pump inhibitors (PPIs)

1/ Many people take #PPIs but up to 50% don’t have a good reason to take them > 8 wks

Read on for tips on how you as a clinician can work together with pts to decide if/how to 🛑 or reduce PPIs

#MedEd #deprescribing Image
2/ Does this person need #PPIs long-term (> 8 wks)?
 
Find pts who might not need long-term PPI:
1⃣ Flag refill requests
2⃣ Use a poster or video in waiting room
3⃣ Run EMR report
 
This @bmj_latest article has more tips to help with #deprescribing PPIs: bit.ly/3fisHsT
3/ Indications for long-term #PPIs include:

Barrett’s esophagus, previous bleeding ulcer, chronic NSAID use w/ mod/severe bleed risk, severe esophagitis, Zollinger-Ellison syndrome
 
If no indication for long-term PPI + no ongoing upper GI symptoms, discuss poss #deprescribing Image
Read 7 tweets
Sep 15, 2022
🧵 Reducing #PrescribingCascades ⬇️

1/ What are #Prescribing Cascades?

1⃣ A drug is prescribed 💊
2⃣ #AdverseEvent occurs but is misinterpreted as a new medical condition ⚠️
3⃣Another drug is prescribed for the drug-induced adverse event 💊💊

ti.ubc.ca/letter138 #MedEd Image
2/ Anticholinergics ➡️ cognitive dysfunction ➡️ drugs for #dementia

#Anticholinergic 💊 block acetylcholinergic neurotransmission in the brain, impairing cognition & memory

Can lead to new Rx or ↗️ acetylcholinesterase inhibitor doses

ti.ubc.ca/letter138 #MedEd #FOAMed Image
3/ Drugs for #dementia ➡️ incontinence ➡️ anticholinergics

Conversely, AChE-I can cause urinary or fecal incontinence, that may "cascade" to prescription of an #anticholinergic

👉🏽 full Letter here: ti.ubc.ca/letter138

#MedEd #PrescribingCascades #MedTwitter Image
Read 10 tweets
May 26, 2022
THREAD: #Prescribers, how do YOU respond to Conflicts of Interest (COI)? 👀

1/8 This thread looks at the issues highlighted in our TI Therapeutics Letter on COI

👉🏼Full Letter: ti.ubc.ca/letter136

#ConflictofInterest #MedEd #MedicalEthics
2/8 Kirsten is a clinical pharmacist attending a primary care conference👩🏽‍⚕️

When a keynote speaker reports financial relationships💰with several drug companies, Kirsten takes note🤨

Find out why she prefers #MedEd free of commercial sponsorship: ti.ubc.ca/letter136
3/8 Key Opinion Leaders (KOLs)

It's common practice to cultivate “expert” KOLs who are crucial to market success💵of a new drug

Payments to KOLs are reported in USA but similar disclosure does NOT exist in Canada
go.nature.com/39XdVVq

#FinancialInterests #ConflictofInterest
Read 9 tweets
May 16, 2022
THREAD: Online Portraits for BC family physicians

1/7 UBC’s Therapeutics Initiative now has Online #PrescribingPortraits: ti.ubc.ca/portrait

✅ Timely evidence
✅ Personalized, confidential prescribing data
✅ Recommendations to support

#BetterPrescribing & #BetterHealth Image
2/7 Why have a #PrescribingPortrait?

"How do I prescribe compared to others or to evidence standards?"

✅Portrait does NOT tell individual doctors how to practice
✅Portrait DOES promote optimal prescribing based on best available evidence

More here: ti.ubc.ca/portrait Image
3/7 BC family physicians: How do you prescribe ACEIs and ARBs for #hypertension?

✅Register for your Online #PrescribingPortrait: ti.ubc.ca/portrait

✅View a sample portrait on prescribing of antihypertensives: ti.ubc.ca/2022/01/28/ace…

#BetterPrescribing #MedEd Image
Read 8 tweets

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