1/People keep asking what they can “do” now that they’re vaccinated (half of adults in Canada!). Can we follow the @CDCgov advice here in Canada too? What evidence can we use to guide us?
2/The @CDCgov has said that fully vaccinated people can attend small outdoor gatherings and even outdoor dinners without a mask, including with people who are unvaccinated.
3/The @CDCgov advice makes a lot of sense because vaccinated people are less likely to get sick – i.e. the risk of symptomatic infection for vaccinated people is much lower. And risk of severe disease is almost nil.
4/ But we also know that they are less likely to even get the virus (i.e. asymptomatic infection). After vaccination, the risk of all infections, including asymptomatic infection, is clearly lower, by up to 90%: cdc.gov/mmwr/volumes/7…
5/Finally, it was recently confirmed that even in those who do become infected, risk of viral transmission is lower - by 40-50% (even after a single vax dose) - compared to infected people who were not vaccinated (likely from lower viral load):
khub.net/documents/1359…
6/So: vaccination (even 1 shot, though less so than 2 shots) reduces symptomatic infection, asymptomatic infection, and transmission. You are unlikely to get sick, but even if you do, you are less likely to pass it on.
7/ So just being vaccinated is v. good to begin with. Now add another layer of security – being outside. Transmission in outdoor settings, barring superspreader events with yelling and close contact, is very low (about 20x lower than indoor transmission):
academic.oup.com/jid/article/22…
8/Putting all that together, it makes sense to allow vaccinated people to congregate in small outdoor gatherings, unmasked. And even for outdoor picnics/dinners unmasked. And if unvaccinated people are present, those vaccinated need not mask because they are so well protected
9/The protection is a little lower for 1 shot vs 2, but still excellent once you are 2-3 weeks post vax (>80% protection with mRNA vaccines). However, we are still learning about how long that immunity lasts between shots, and protection from variants. cdc.gov/media/releases…
10/At the end of the day, this is a balanced approach that does not aim for zero risk but acknowledges a significant reduction in risk. And a need to get back to some form of normal. A similar approach would make sense for Canada. #harmreduction
11/But maybe the most important reason to do this is that getting to herd immunity will require giving vaccine hesitant people a carrot. Some may distrust science, buy into conspiracies, obsess about risks, but presenting a path to return to normal will move many to get the shot
12/And if that doesn't work, we can always just give people $100:😜nytimes.com/2021/05/04/ups…

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More from @SammyG_MD

13 May
1/ Small Gupta family case series. Now 31 relatives + 4 friends with COVID in India. 32/35 took steroids. All were normoxic when given steroids (3 later deteriorated and actually needed them).
2/ Typical outpatient starting dose is medrol 32mg/day or equivalent. All of them get a taper, total duration 14-18 days. (If actually hypoxemic and hospitalized, doses are much higher - in the medrol 80 bid range. And durations even longer).
3/ CRP, IL-6 being measured every few days in outpatients and steroids titrated accordingly. Remember - these people all have saturations >95%.
Read 6 tweets
4 May
1/Re. NACI’s recent communications. No one is saying to hide info from the public. What people are concerned about is the way that info is being conveyed (and to some extent, its accuracy). IMO, here is how they should have framed this:
2/First: all vaccines are extremely effective. All of them, including the AZ vaccine, will prevent severe disease and death in close to 100% of people. This is NOT about effectiveness.
3/Second: if you got your AZ vaccine over a month ago, you are golden – you will not get this clotting complication and you should have ZERO REGRETS!
Read 9 tweets
6 Oct 20
1/Lots of discussions about #lockdown vs no lockdown in medicine, politics, around dinner tables, just about everywhere. @fordnation says he needs more evidence. I just reviewed the topic for a debate @accpchest. So I'll oblige. theglobeandmail.com/canada/article…
2/I'll start by stating the obvious: lockdowns work. This was shown in multiple Spanish Flu pandemic studies, including this one demonstrating reduced excess flu mortality with earlier, more aggressive lockdown, comparing 43 US cities: pubmed.ncbi.nlm.nih.gov/17684187/
3/100 years later, evidence holds. COVID-19 lockdowns reduce transmission, hospitalizations/ICU, deaths. Shown in modelling, pre/post, interrupted time series, contemporaneous group predictor studies, across continents, countries. Excellent meta-analysis: bmj.com/content/370/bm…
Read 13 tweets

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