💡Potential RNA therapy against #SARSCoV2 infection via lipid nanoparticle delivery on horizon. Small-interfering RNAs (siRNAs) targeting the virus were screened that effectively inhibit virus by >90% either alone or in combination. #COVID19 (link below)
3) “Encapsulation of siRNAs in LNPs followed by in vivo injection ➡️ robust repression of virus in the lungs and a pronounced survival advantage to treated mice. Our LNP-siRNA approaches are scalable and can be administered upon the first sign of SARS-CoV-2 infection in humans.”
4) “We suggest that an siRNA-LNP therapeutic approach could prove highly useful in treating COVID-19 disease as an adjunctive therapy to current vaccine strategies.”
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