People seem to equate lockdowns with a 0 covid tolerance approach

I recall lockdowns are used in a "herd immunity" approach just before hospitals are overwhelmed.

In fact, "herd immunity" pursuant countries have arguably spent the most time in lockdown
The pursuit of herd immunity is probably why schools are used by some countries for a populational "natural" immunity

Infected children are less frequently hospitalized (1%). However, they are also less likely to seroconvert

Children do, however, infect young parents
In fact, you can see this pattern of children infecting parents from schools.

This could be why there are right-wing lobby groups for no masking.

They want to achieve an infection-based immunity period all the more quickly.
If you vaccinate the children you protect them, but you also reduce their ability to infect others.

This is a detriment for those interest groups that want immunity at all cost, like the @aier
The aier, profiteers, and lazy governments will fight tooth and nail against vaxxing kids

They will platform antivaxx in order to get back to "normal" sooner as they want those $ flowing, and those 1% hospitalizations of kids don't matter to them

"like a vaccinated Grandparent"
This may be "@insight," but my suspicion is that even left-wing yet "fiscally conservative" platforms like @TheAtlantic which claim 'liberals can't leave lockdown' want offices full and masks off

All at the expense of the 10% or so where the vacc doesn't work
We keep seeing the same tired data about t cells existing and fraud accounts (a la cambridge analytica et al) parroting T cell immunity, etc. The virus hides from T cells. I believe @zeynep shared an article showing t cells exist vs Cov2

They are impeded
Immunologists are tired of seeing in vitro assays showing T cells exist, and these used and abused by opportunists for false promises of natural immunity

As noted above, this is an entirely separate context to infection. There is no MHC impediment!
Furthermore, some "herd immunity" pursuant countries have spent the most time in lockdowns and have had the most deaths *because* infection-based immunity is subpar

Frauds are scared to admit this

Fools and Non-immunologists failed to grasp the extent of the lymphomanipulation

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Anthony J Leonardi, PhD, MS

Anthony J Leonardi, PhD, MS Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @fitterhappierAJ

23 May
Kids need to be vaccinated. Why?

Because things can go horribly wrong with infection, and infection is a process with proof of continuation.

Let's look at a few coronavirus examples and how they relate to cov2 🧵
Feline Infectious Peritonitis has a Furin Cleavage Site *EQUIVALENT* to Cov2

Fip in cats is notably a fatal, incurable, chronic illness, which interestingly requires a form/precursor of remdesivir to cure.

This must be given for 100 days.
So the cats bodies mount a response to the virus, but it is able to hide out and mutate in some, and cause vasculitis and neuroinflammation.

Sound familiar? vet.cornell.edu/departments-ce…
Read 9 tweets
11 May
This is important:

B.1.617 has mutations that may *enhance* pathogenesis

A mutation at P681R in combination with L452R and E484Q significantly increases syncitia formation

This is when the cells fuse together, and it's linked to fatal disease.
2/ The Gupta lab found the mutations L452R/E484Q/P681R together significantly increase Syncitia formation.

This is a function of the polybasic cleavage site. Syncitia formation is linked to fatal diseasehttps://www.biorxiv.org/content/10.1101/2021.05.08.443253v1
3/ Syncitia are a way the virus kills T cells

This paper in Cell Death and Differentiation discusses how Syncitia internalize T cells in order to kill them

nature.com/articles/s4141…
Read 7 tweets
18 Apr
This thread is in regard to the concerning things about Cov2.
I owe the idea to @LgSOS

To start, we have the neuroinvasion seen by @ericsongg @VirusesImmunity et al. rupress.org/jem/article/21…
2/ There is also a predominant symptom of anosmia (loss of sense of smell).

This anosmia is seen as unlikely to be from mucosal/nasal swelling ncbi.nlm.nih.gov/pmc/articles/P…
3/ Interestingly, a few case reports have emerged of Parkinson's following infection.
thelancet.com/journals/laneu…
A worrisome correlate may exist as seen by this preprint: monkeys had precursors of Parkinson's after infection, called Lewy Bodies biorxiv.org/content/10.110…
Read 7 tweets
17 Apr
1/This is concerning.

A human endogenous retroviral protein is being induced in lymphocytes in Covid-19.

This is the same HERV implicated in Epstein Barr's association with Multiple Sclerosis
thelancet.com/journals/ebiom…
🧵
2/ Cov2 is eliciting the same human Endogenous retrovirus as Epstein Barr, and the expression increases with T cell differentiation 🤯 Image
3/ Interestingly, Epstein Barr virus will "awaken" parts of an endogenous human retrovirus-

this is an ancient virus lurking in our DNA

It functions like a superantigen and stimulates lymphocytes.
ncbi.nlm.nih.gov/pmc/articles/P…
Read 4 tweets
9 Apr
I've not seen so much power and simplicity in data for a long time.

Cov2 is generating T cell escape epitopes, and there may be a dominant selection for a nucleocapsid site for B*27:05
biorxiv.org/content/10.110…
🧵 1/
2/ The authors show a number of mutated peptides/variants that cause partial or complete loss of T cell reactivity for certain HLAs
3/ In my opinion, there can be a degree of selection against T cell epitopes when T cells are being used to react to virus- the situation where one has T cell memory but no sera. I think I mentioned this exact scenario before @MonicaGandhi9?
Read 6 tweets
7 Apr
On the contrary, we should worry about variants "escaping" CD8+ immunity, especially if one has HLA:24

I am surprised- maybe we are awaiting publication? @NahasNewman

As of yet this sort of escape has been mostly theoretical. biorxiv.org/content/10.110…
When we lose CD8 reactivity, we lose our ability to cull infected cells. 😱

Something we were promised so frequently would not happen, but it did! @zeynep
They were warned in a light way, but it didn't get through 😔

This is my biggest fear manifest, and what did the AIER/Pandata/GBD crowd do? they passaged the virus in schools per Azar 😰
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(