The aier, profiteers, and lazy governments will fight tooth and nail against vaxxing kids
They will platform antivaxx in order to get back to "normal" sooner as they want those $ flowing, and those 1% hospitalizations of kids don't matter to them
"like a vaccinated Grandparent"
This may be "@insight," but my suspicion is that even left-wing yet "fiscally conservative" platforms like @TheAtlantic which claim 'liberals can't leave lockdown' want offices full and masks off
All at the expense of the 10% or so where the vacc doesn't work
We keep seeing the same tired data about t cells existing and fraud accounts (a la cambridge analytica et al) parroting T cell immunity, etc. The virus hides from T cells. I believe @zeynep shared an article showing t cells exist vs Cov2
Immunologists are tired of seeing in vitro assays showing T cells exist, and these used and abused by opportunists for false promises of natural immunity
As noted above, this is an entirely separate context to infection. There is no MHC impediment!
Furthermore, some "herd immunity" pursuant countries have spent the most time in lockdowns and have had the most deaths *because* infection-based immunity is subpar
Frauds are scared to admit this
Fools and Non-immunologists failed to grasp the extent of the lymphomanipulation
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B.1.617 has mutations that may *enhance* pathogenesis
A mutation at P681R in combination with L452R and E484Q significantly increases syncitia formation
This is when the cells fuse together, and it's linked to fatal disease.
2/ The Gupta lab found the mutations L452R/E484Q/P681R together significantly increase Syncitia formation.
This is a function of the polybasic cleavage site. Syncitia formation is linked to fatal diseasehttps://www.biorxiv.org/content/10.1101/2021.05.08.443253v1
3/ Syncitia are a way the virus kills T cells
This paper in Cell Death and Differentiation discusses how Syncitia internalize T cells in order to kill them
3/ Interestingly, a few case reports have emerged of Parkinson's following infection. thelancet.com/journals/laneu…
A worrisome correlate may exist as seen by this preprint: monkeys had precursors of Parkinson's after infection, called Lewy Bodies biorxiv.org/content/10.110…
I've not seen so much power and simplicity in data for a long time.
Cov2 is generating T cell escape epitopes, and there may be a dominant selection for a nucleocapsid site for B*27:05 biorxiv.org/content/10.110…
🧵 1/
2/ The authors show a number of mutated peptides/variants that cause partial or complete loss of T cell reactivity for certain HLAs
3/ In my opinion, there can be a degree of selection against T cell epitopes when T cells are being used to react to virus- the situation where one has T cell memory but no sera. I think I mentioned this exact scenario before @MonicaGandhi9?