Thread by @fitterhappierAJ

Kids need to be vaccinated. Why?

Because things can go horribly wrong with infection, and infection is a process with proof of continuation.

Let's look at a few coronavirus examples and how they relate to cov2 🧵

https://twitter.com/PoliticsPollss/status/1395793536453328903

Feline Infectious Peritonitis has a Furin Cleavage Site *EQUIVALENT* to Cov2

Fip in cats is notably a fatal, incurable, chronic illness, which interestingly requires a form/precursor of remdesivir to cure.

This must be given for 100 days.

https://twitter.com/K_G_Andersen/status/1391507250158587906

So the cats bodies mount a response to the virus, but it is able to hide out and mutate in some, and cause vasculitis and neuroinflammation.

Sound familiar? vet.cornell.edu/departments-ce…

Some immunologists theorize there could be a neural reservoir for cov2

In a chicken coronavirus, a similar Furin Cleavage Site enabled neurotropism which engendered neural symptoms and more illness
pubmed.ncbi.nlm.nih.gov/32057769/

Here is a nice review of the neurological/encephalitic models of neurotropic viruses as they relate to cov2

We do not know if there will be a later manifestation

If it is like measles it would be tragic
ncbi.nlm.nih.gov/pmc/articles/P…

I'm not a virologist, but I try to extrapolate what I see and compare it to pathogens with other features.

Basically this is
✅neurotropic
✅has a superantigen
✅potentially chronic

So when I think of bad hombres in the brain, I think of
✅measles
✅HIV related dementia
✅Rabies
✅OC43

So thank goodness we are not seeing anything like hydrophobia despite rabies and cov2 being superantigenic, so we can set that aside.

However, OC43 has many of the same neurotropic features

but cov2 also has a superantigen, as does HIV
news-medical.net/news/20200504/…

So if I were to imagine, I would say we will see an uptick of cov2 related neuropathology in the long term

How bad?

That's for the fates to decide.

There is ample bioplausibility for tragedy, though.