NEW—UK reports that 2 doses of AstraZeneca vaccine efficacy for #B16172 India variant: just 60%. And latest study says #B117 efficacy just 66% (lower than before). 1-dose efficacy 33% for #B16172.
2) that said, the Pfizer-BioNTech vaccine was 88% effective against symptomatic disease from the B.1.617.2 variant 2 weeks after the second dose, compared to 93% effectiveness against the B.1.1.7 variant
3) “both vaccines were 33% effective against symptomatic disease from B.1.617.2, 3 weeks after the first dose compared to around 50% effectiveness against the B.1.1.7 variant”
4) Some are saying, “these Indian variant data is wonderful news!” ummmm, not quite. There is an outbreak surge in #B16172 in kids in several cities in UK. And now there is a UK govt coverup… to hide outbreak!!!
5) Let’s put the 1 dose results in perspective—back in March, nationwide Uk study found that 1 dose of the Oxford-Az vaccine was 60% effective around ~3 weeks. That now drops to 50% for #B117 & just 33% for B16172. ➡️Many countries rely on 1 dose approach. medrxiv.org/content/10.110…
6) to be clear—these new efficacy numbers for the variants are *not* from more rigorous trials— they are from a quick and dirty case control study. Other experts like @trishgreenhalgh are not impressed either.
7) Also, many people reading the FT article yesterday saying 81% efficacy for #B16172 — that’s not AZ vaccine specifically— 81% was the mixture of Pfizer, Moderna, and AZ. AZ efficacy alone was the much lower value … see top post ⬆️
8) there is some sketchy coverup emerging in the UK by the Johnson administration— They are hauling some Astrazeneca vaccine and variant “success”. But it’s much worse than expected, and they are covering up the Indian variant outbreak in schools and cities across UK.
9) it’s a new #B16172 coverup saga, but long story short, 10 Downing Street blocked key parts of the PHE’s report on the Indian variant outbreak… muzzling the school outbreak data.
We I see a clear documented coverup- that gets me worried about how bad #B16172 truly is.
Residents in the epicenter of UK’s #B16172 variant outbreak, in Bolton 🇬🇧, told not leave the city unless it is essential, under new guidelines published. Hospitalization soaring along with cases. 90% of all #COVID19 in Bolton is the worrisome #B16172. 🧵 theboltonnews.co.uk/news/19325835.…
2) look how much cases in Bolton has increased… 113% in one week. But many other places too. Bolton just the largest so far.
3) this is part of the bigger nationwide surge in the UK driven mostly by #B16172. See detailed thread 🧵 for more details of the outbreaks… ⬇️
Hospitals in Osaka, Japan buckling under a huge wave of #COVID19, running out of beds, ventilators, and even intubation medicine—as exhausted doctors warn of a "system collapse", and advise against holding the Olympics. Even only ~half of HCW vaccinated. 🧵reuters.com/world/asia-pac…
2) The speed at which Osaka's healthcare system was overwhelmed underscores the challenges of hosting a major global sports event in two months' time, particularly as only about half of Japan's medical staff have completed inoculations.
3) "Simply put, this is a collapse of the medical system," said Yuji Tohda, the director of Kindai University Hospital in Osaka.
⚠️PAY ATTENTION to rising #B16172 crisis in UK—crucial because India variant affects us all. It is now ~50% of all cases in England, surging fast, especially in kids. Hospital #COVID19 ward in Bolton🇬🇧 filling up. “It’s too late to contain” @chrischirp 🧵 assets.publishing.service.gov.uk/government/upl…
2) And key worry is that the surge in #B16172 is domestic community transmission. Not related to international travel.
3) And look at the growth rate! #B16172 variant is by leaps and bounds growing faster than any other variant. The previously fast #B117 is growing much much slower—5x slower than B16172.
There can be 2 reasons—higher transmissibility, or more reinfection / vaccine breakthroughs.
It’s sickening to watch UK’s CDC equivalent (Public Health England) now being an outlet of Boris Johnson administration’s propaganda. Yesterday, Johnson’s office censored PHE from publishing #B16172 outbreak data in schools—and then hails 33-60% 1&2 dose efficacy as a win for AZ.
2) to be clear, while 60% 2-dose efficacy is good, it’s not great. And asymptomatic infection likely lower. And 33% 1 dose is tricky too given how many countries rely on one dose strategy.
Staggering—at least 3 million excess deaths in 2020–which is **1.2 mil** more than the 1.8 mil official numbers: WHO estimates that is the excess in the America & Europe alone (data not yet including Asia, Africa, Middle East).
2) “Excess mortality is defined as the difference in the total number of deaths in a crisis compared to those expected under normal conditions. COVID-19 excess mortality accounts for both the total number of deaths directly attributed to the virus as well as the indirect impact”
3) what about undercount? “A recent assessment of health information systems capacity in 133 countries found that the percentage of registered deaths ranged from 98% in the European region to only 10% in the African region.” Damn! who.int/data/data-coll…
Muzzling risks in schools—Downing Street (Boris Johnson) censored @PHE_uk and prevented crucial data on spread of new #COVID19 variant in schools—notably blocking data on Indian variant school spread. Scientists & teachers said it was “deeply worrying”. 🧵 theguardian.com/world/2021/may…
2) “The focus of their anger concerns the pre-print of a PHE report that included a page of data on the spread of the India Covid-19 variant in schools. But when the report was published on Thursday 13 May, the page had been removed.”
3) “It was the only one that had been removed from the pre-print. Days later, the government went ahead with its decision to remove the mandate on face coverings in English schools.”