A 70 yo W with history of HTN presented with significant IVH from a ruptured AVM.
Admission EKG showed this:
A #brugada pattern. She had no personal or family history of syncope / sudden death. And on admission (time of this EKG) she was not febrile. About 12 hours later we repeated the EKG:
Trops normal and ECHO later in the day demonstrated a normal EF and grade 1 DD, but no wall motion abnormality. No apical ballooning. There was mildly increase LV wall thickness.
Checked another EKG the next AM. Looks about the same.
There were no arrhythmias on tele. She continued to be afebrile.
A few days later (about 6 days out from IVH), she developed a pneumonia and spiked a temperature.
Repeat EKG demonstrated:
Absent Brugada pattern, despite the fever (1st of her admission).
So, #cardiotwitter, do we just chalk this up to a brain-heart ❤️🧠 connection thing? The stress of IVH? Inflammation? Never personally seen this pattern with neuro patients so I'm curious!
And -- Is it likely to return? Or like all the QTc prolongations & other transient arrhythmias we find is this unlikely to reoccur.
Thoughts on why this pattern might be found with neuro injury?
1/ 1st week of NeuroICU fellowship. A #tweetorial summary:
1⃣ Pt in DI. Give anti-diuretic hormone (ADH), call it “pit drip”
2⃣Pt in distributive shock. Give ADH, call it “vaso”
3⃣Pt on ASA needs EVD. Give ADH (sort of), call it “DDAVP”
4⃣ Fellow postcall & confused, give….
2/ Just kidding… everyone knows the drug for that is
3/ All the names and purposes of ADH had me feeling ⬇️
So – a review of all things ADH including:
✅It’s various aliases
✅Receptors and function
✅Clinical utility in NeuroICU (+general ICUs)
2/ With the TREAT-CAD trial, lots of talk about dissection treatment. Whether your team anti-platelets or team anticoagulation (🙋🏻 Must. Give. Heparin (@MGHNeurology) 4 ever. I know you feel this, @namorris!) consideration about the location of dissection is possibly important.
3/ Also, regardless of your team… TREAT-CAD was not able to demonstrate non-inferiority of ASA, just saying.
Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiorit… pubmed.ncbi.nlm.nih.gov/33765420/
2/
First and foremost, let’s be clear that to be dead by brain criteria, the patient must have cessation of ALL brain function *INCLUDING absence of respiratory drive.*
Thinking "But... I thought you just said...."?
3/
The contradiction here lies in that ventilators are sometimes too sensitive.
2/ Reminder: The 12 cranial nerve nuclei are located in the brainstem, and if you have trouble remembering where they are, welcome to the club. Here’s a reminder! Will post the medulla section Monday, stay tuned.
3/ We’ll move from central to peripheral etiologies.
The brainstem is like Times Square in NYC- so much going on in a very small space.
A small insult can easily cause damage to multiple cranial nerves. amiright, #stroketwitter?