Alternate day fasting —every other day you east for 24hrs May work but is not sustainable. I will not be using this #AACE2021#endotwitter
Alternate day modified intermittent fasting (25% caloric intake# one day and 125% following day) maybe better for some secondary measures but not sustainable and conflicting results on if it is better for weight loss #AACE2021#endotwitter
5:2 diet — 2 days eat a very low diet (25-35%) —results conflicting with half showing benefit and half not showing benefit #AACE2021#endotwitter
Meta-analysis of intermittent fasting diets not sig for weight loss but benefit in insulin resistance and maybe hdl/trigs #AACE2021#endotwitter
Never heard of this one—fasting mimicking diet. No comparisons to regular diet but compared to placebo it is beneficial in many parameters in addition to weight incl tumor reduction #AACE2021#endotwitter
Weekly intermittent fasting —one week very low calorie and one week normal calorie. Original study showing good weight loss but overall not a lot of long term data #endotwitter#AACE2021
Here is the one I rec the most —time restricted intermittent fasting (fasting for 14+hrs daily). Benefits proportional to length of fast and doing it 5 days may be as good as 7 days #Endotwitter#AACE2021
But eating later is not better and may actually be worse for cardio metabolic health! #Endotwitter#AACE2021
Glycemic control and glucose tolerance is much better in the morning then later in day. This graph shows results of ogtt performed in morning compared to evening #afternoonDiabetes#Endotwitter#AACE2021
A change (weakened or misalignment) to our circadian rhythm can make it harder to lose weight #obesity#AACE2021#Endotwitter
Bottom line - eating at night (aka “out of sync with circadian rhythm”) is bad bad bad #Endotwitter#AACE2021#obesity
Is skipping breakfast bad? Prob not unless u are also eating a late dinner. Bottom line don’t eat late dinner #AACE2021#Endotwitter#obesity
In dr Peterson study intermittent fasting (time restricted) did not increase energy expenditure but it did increase fat burning and decrease hunger and glu levels #Endotwitter#AACE2021#obesity
Eat your veggies and protein first and leave the carbs for last #Endotwitter#AACE2021
Phenomenal talk by Dr. Courtney Peterson on intermittent fasting and does time of day matter. If you missed it I would recommend going back to watch #AACE2021#Endotwitter
Let's hear The Evidence For and Against Combination #Thyroid Hormone therapy by Dr. Bianco #AACE2022#Endotwitter. This conversation is controversial here are some of the main slides
Patient's on Lt4 reporting a lot of residual symptoms in energy, cognition
Normal physiology the majority of thyroid hormone production is T4 (16:1 T4:T3) and gets converted peripherally to T3 (5mcg made in thyroid, 25mcg made peripherally)
Now to talk about Phosphatonins and #phosphorus metabolism/bone disease by Dr. Kumar moderated by @sfeirjad...I'm ready to learn since admittedly I know little of this #AACE2022#Endotwitter#bone
Why bother about phosphorus? Well it plays many roles in cellular signaling and maintenance of membrane structure of #bone. Low concentrations associated with rhabdo, decreased cardiac function and bone dysfunction (#osteomalacia, #rickets). low and high phos causes bone disease
High Phos Concentrations are Associated with CV Disease and Excess Mortality in CRF and decreasing levels reduces CV mortality
Look how far we have come in #diabetes technology and there is still a lot more to go #AACE2022. #CGM technology has been a game changer and the accuracy continues to improve with each generation
So what's new in the pipeline for #diabetes technology? Let me tell you starting with #dexcom G7. It will be smaller with a better MARD, better warm up and ALL-IN-ONE applicator and transmitter! Just pending FDA review #AACE2022#endotwitter#medtwitter
#NAFLD has effects on other conditions including DM, CVD, CKD etc due to increased hyperinsulinemia, insulin resistance, proinflammatory factors etc
How do we screen for #NAFLD and find the ones with fibrosis? A lot will be missed if just checking transaminases. FIB-4 and NFS is a better screening tool