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Coronavirus update Profile picture
@BitaScicomm
May 30, 2021 • 4 tweets • 1 min read • Read on X
Who should NOT get Pfizer or Johnson vaccine?

According to CDC: If you are allergic to

☆polyethylene glycol (PEG), you should NOT get either of the mRNA COVID-19 vaccines (Moderna or Pfizer).

☆polysorbate, you should not get the Johnson & Johnson vaccine.

1/
If you are allergic to other types of vaccines, for example, the flu shot, you should consult your doctor before scheduling a COVID-19 vaccine.

2/End
CDC recommendations for people with a previous history of allergic reactions👇👇👇

cdc.gov/coronavirus/20…
@ChHanekom

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More from @BitaScicomm

Coronavirus update Profile picture
Sep 4, 2021
Kidney outcomes in LongCovid
Bowe et al., 2019

What's #LongCovid?

it's scientifically proved that COVID-19 is not death or survival. The disease is associated with increased risk of post-acute sequelae involving pulmonary and extrapulmonary organ systems called #longCOVID.
1/
Q: What was the aim of this study?

Scientists wanted to evaluate the detailed assessment of kidney outcomes in long COVID.
2/
What did scientists do?From Mar 2020-Mar2021 they built a cohort of:
Total: 1,726,683 people
☆89,216 were 30-day COVID-19 survivors
☆1,637,467 non-infected controls
They examined risks of decline in kidney fuction&major adverse kidney events(decline in kidney function≥50%)
Read 12 tweets
Coronavirus update Profile picture
Aug 26, 2021
Lets unpack this study.

Morbidity and mortality from COVID-19 post-vaccination breakthrough infections in
association with various COVID-19 vaccines and the emergence of variants in the Kingdom of Bahrain.

AlQahtani et al., 2021

1/
We know that:

1. Vaccines were designed against the original variants

2. The virus is keep mutating

3. Breakthrough infections occur.

4. Vaccines protects against severe illness& death

So, they are Critical questions that needs to be asked.

2/
Q: What was the aim of this study?

1.What is the effectiveness of various vaccines in
preventing infection, symptomatic disease, hospitalization,ICU admission&death

2.What are the clinical consequences of post-vaccination infections in the context of
emerging variants
3/
Read 11 tweets
Coronavirus update Profile picture
Jul 28, 2021
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner:

What was the aim of this study?

To evaluate the effect of prior Covid-19 infection on Ad26.COV2.S immunogenicity approximately 28 days post-vaccination.
1/
What does immunigenicity mean 🤔?

Immunogenucity= how well a vaccine works+ measures the type of immune responses that the vaccine generates over time
2/
What did researchers do?

They compared:
A: healthcare workers (HCWs) without previous history of covid19 infection

B: HCWs infected during the first wave prior to the emergence of Beta

C: HCWs infected in the second wave, when Beta was the dominant variant.
3/
Read 7 tweets
Coronavirus update Profile picture
Jul 28, 2021
The study investigated 6 Month Safety and Efficacy of the Pfizer Vaccine:

How?

A total of ~47,000 including 44,165 ≥16-year-old participants& 2,264 12-15-year-old participants were randomized to receive 2 doses, 21 days apart, of 30 μg vaccine or placebo.
1/
What do they report here?

Study endpoints reported here are vaccine efficacy (VE) against laboratory-confirmed COVID-19 and safety data, both up to 6 months post-vaccination.
2/
What did they find?

☆Pfizer vaccine continued to be safe and well tolerated.

☆VE against COVID-19 was 91% through up to 6 months of follow-up
☆VE of 86%‒100% was seen across countries and in populations with diverse characteristics of age,
3/
Read 7 tweets
Coronavirus update Profile picture
Jul 28, 2021
#Covid19vaccines

This work aim at evaluating the immunogenicity of the Sinopharm, antibody responses against different SARS-CoV-2 variants of concern in individuals in Sri Lanka.
1/
What did they do?

They measured the SARS-CoV-2-specific antibodies (abs) in 282 individuals 2 weeks after 2d dose.

2/
Some technical details😉 on what they measured.

sero - at baseline,& ACE2 receptor blocking abs, abs to the RBD of the wild type (WT), B.1.1.7, B.1.351 and B.1.617.2, ex vivo&
cultured IFNγ ELISpot assays, intracellular cytokine secretion assays and B cell ELISpot assays.
3/
Read 10 tweets
Coronavirus update Profile picture
Jul 27, 2021
#Getvaccinated

#COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors

☆Up to 20%–30% of patients hospitalized with COVID-19 have evidence of myocardial involvement.

1/
☆Acute cardiac injury in patients hospitalized with COVID19 is associated with higher morbidity&mortality.

☆Myocarditis from viralpathogens can evolve into overt or subclinical myocardial dysfunction, and cause death.This raises concerns 4 patients recovering from COVID-19.
2/
☆Some patients will have subclinical and possibly overt cardiovascular abnormalities.

☆Patients with ostensibly recovered cardiac function may still be at risk of cardiomyopathy and cardiac arrhythmias.
3/
Read 4 tweets

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