Postdoc | Microbiologist | #FullyVaccinated
Passionate about role of microbes on health& disease. I raise awareness about #Covid19, Fungal Infections, TB&..
it's scientifically proved that COVID-19 is not death or survival. The disease is associated with increased risk of post-acute sequelae involving pulmonary and extrapulmonary organ systems called #longCOVID.
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Q: What was the aim of this study?
Scientists wanted to evaluate the detailed assessment of kidney outcomes in long COVID.
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Aug 26, 2021 • 11 tweets • 4 min read
Lets unpack this study.
Morbidity and mortality from COVID-19 post-vaccination breakthrough infections in
association with various COVID-19 vaccines and the emergence of variants in the Kingdom of Bahrain.
AlQahtani et al., 2021
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We know that:
1. Vaccines were designed against the original variants
2. The virus is keep mutating
3. Breakthrough infections occur.
4. Vaccines protects against severe illness& death
So, they are Critical questions that needs to be asked.
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Jul 28, 2021 • 7 tweets • 1 min read
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner:
What was the aim of this study?
To evaluate the effect of prior Covid-19 infection on Ad26.COV2.S immunogenicity approximately 28 days post-vaccination.
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What does immunigenicity mean 🤔?
Immunogenucity= how well a vaccine works+ measures the type of immune responses that the vaccine generates over time
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Jul 28, 2021 • 7 tweets • 2 min read
The study investigated 6 Month Safety and Efficacy of the Pfizer Vaccine:
How?
A total of ~47,000 including 44,165 ≥16-year-old participants& 2,264 12-15-year-old participants were randomized to receive 2 doses, 21 days apart, of 30 μg vaccine or placebo.
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What do they report here?
Study endpoints reported here are vaccine efficacy (VE) against laboratory-confirmed COVID-19 and safety data, both up to 6 months post-vaccination.
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This work aim at evaluating the immunogenicity of the Sinopharm, antibody responses against different SARS-CoV-2 variants of concern in individuals in Sri Lanka.
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What did they do?
They measured the SARS-CoV-2-specific antibodies (abs) in 282 individuals 2 weeks after 2d dose.
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#COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors
☆Up to 20%–30% of patients hospitalized with COVID-19 have evidence of myocardial involvement.
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☆Acute cardiac injury in patients hospitalized with COVID19 is associated with higher morbidity&mortality.
☆Myocarditis from viralpathogens can evolve into overt or subclinical myocardial dysfunction, and cause death.This raises concerns 4 patients recovering from COVID-19.
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Some vaccines: 1. Stop you getting symptomatic disease (#Covidvaccines )
2. Others stop you getting infected too ( Smallpox)
The latter is known as “sterilising immunity”.
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What is “sterilising immunity”?
Vaccines that provide sterilising immunity, doesn't even let the pathogen ( virus) gain a toehold in the body because the immune system stops the virus entering cells and replicating.
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Jul 10, 2021 • 9 tweets • 2 min read
1.Antivaxers: vaccines are not safe.
Me: haven't you been vaccinated (Polio, Diphtheria &..) since you were born?
2.Antivaxers: but mRNA vaccines are new!
Me: Efforts to create an mRNA vaccine have been ongoing since 1993, when scientists tested mRNA for influenza in mice!
1/3. Anti-vaxers: mRNA vaccines can modify our DNA.
Me: No! Neither the mRNA nor the spike protein enters the nucleus of the cell where the DNA is stored.
They do not come into contact with our DNA or alter it in any way.
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Jul 5, 2021 • 8 tweets • 2 min read
Misinformation about mRNA vaccines!
1.vaccine would “permanently alter your DNA! FALSE
2.spike protein produced by the vaccine would “bind to your DNA and irreversibly change it! FALSE
neither the mRNA nor the spike protein come into contact with our DNA or alter it in any way
3.vaccines will produce more viruses or promote cancer! FALSE
The mRNA introduced through the vaccine survives just long enough to allow the cells to produce spike protein for generating an immune response, aftershock the mRNA will be DESTROYED
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Q: How long we have been working on mRNA vaccines?
A: Efforts to create an mRNA vaccine have been ongoing since 1993, when scientists tested mRNA for influenza in mice.
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Q: How do vaccines work, in general?
A: Vaccines work by mimicking an infection and training the immune system to recognize SARS-Cov-2 virus.
This training allows the body to respond more rapidly when it encounters the virus in the future.
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Jul 5, 2021 • 5 tweets • 2 min read
Covid-19 mRNA Vaccines Are Not ‘Gene Therapy.
What is gene therapy? A technique that “may allow genes to treat or prevent disease.
In the future, this technique may allow docs to treat a disorder by inserting a gene into a patient's cells instead of using drugs.
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Who invented this method?
French Anderson was “dubbed 'the father of gene therapy' after a team he led in 1990 cured a hereditary disease of the immune system in a 4-year-old girl.”
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Jun 30, 2021 • 9 tweets • 2 min read
##Covid19SA
Can COVID-19 Cause Diabetes? Research points to another "troubling" effect of COVID-19: new cases of diabetes.
SARS-COV-2 is NOT like other viruses. It causes severe inflammation throughout the body, wreaking havoc on respiratory system, heart, brain, and kidneys
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The studies, both NIH-supported pre-proof studies available in the journal Cell Metabolism, confirm "that:
☆SARS-CoV-2 can target and impair the body's insulin-producing cells." This, as a result, can lead to diabetes.
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May 30, 2021 • 4 tweets • 2 min read
@DrZweliMkhize 1. Several experts found problematic data in the published phase 1/2 results of Sputnik.
2. Lancet made multiple independent requests for access to the raw dataset, but these were never answered.
The Sputnik V investigators mention that three interim analyses were added to the study on Nov 5, 2020,1 but this change was not recorded on ClinicalTrials.gov.
The full study protocol has not been made available.
There are some health screening every woman should do EVERY YEAR!
☆ Blood analysis
☆ Pap smear
☆Breast ultrasound/ Mamigram
Let's break it down.
1/1. Sceening your blood pressure
☆Starting at age 20: Once every 2 years
☆Adults ages 40 or older: Atleast once per annum
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May 30, 2021 • 4 tweets • 1 min read
Who should NOT get Pfizer or Johnson vaccine?
According to CDC: If you are allergic to
☆polyethylene glycol (PEG), you should NOT get either of the mRNA COVID-19 vaccines (Moderna or Pfizer).
☆polysorbate, you should not get the Johnson & Johnson vaccine.
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If you are allergic to other types of vaccines, for example, the flu shot, you should consult your doctor before scheduling a COVID-19 vaccine.
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May 29, 2021 • 7 tweets • 1 min read
Doctors urge people with comorbidities to take Covid-19 vaccine without hesitation:
Diabetic patients
Cancer patients
Cardiac patients
Patients with kidney ailments
Heart failure with hospital admission in past one year
Post cardiac transplant/Left Ventricular Assist Device
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Significant Left ventricular systolic dysfunction (LVEF < 40%)
