1/6 Really important study by @kfitzgeraldnd highlights the importance of diet + lifestyle in slowing ageing

It even suggests lifestyle changes can reverse ageing by 2 years *IN ONLY 8 WEEKS* by triggering changes in DNA 😲

A short thread...

Article👇
aging-us.com/article/202913…
2/6 The study:

A randomised, controlled trial of 43 healthy men age 50-72. Those in the treatment group had an 8 week programme of:

Diet (more info in next tweet)
Sleep
Exercise
Relaxation
Supplemental probiotics + phytonutrients
3/6 The diet:

A large amount of green, leafy veg👍
Some nutrient-dense animal protein (liver/eggs)👍
Low in carbs #LCHF 👍
Included intermittent fasting👍

The lifestyle changes:

Exercise 5 x 30min/week
Relaxing breathing exercises twice a day
>7 hours sleep/night
4/6 Ageing was assessed by measuring DNA methylation in saliva

Methylation is possibly the best-studied marker of ageing

Methylation levels at several thousand known sites on chromosomes correlate tightly with age/ageing
5/6 It's no surprise to me that diet + lifestyle change slow ageing but the impact is huge (a 2 year improvement after only 8 weeks of change!!!)

There's a lot more info on diet at the @Food_campaignUK website: realfoodcampaign.org.uk
6/6 This study provides more evidence to support how diet + lifestyle affect ageing

The large number of interventions in this study make it hard to understand which elements are most important in slowing ageing

It would be lovely to see this explored further....

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More from @DocRunner1

6 May
1/7 This my patient, Bill - I made him cry today 😢

He's said it's OK to share his story

He's 56. 9 years ago Bill had a big stroke affecting his mobility
His weight⬆️⬆️, he struggled to get out of a chair, ate an unhealthy diet + developed type 2 diabetes

A short thread...
2/7 Bill burst into tears😢when I told him he had reversed his type 2 diabetes👏

He had worried about another stroke, wanted to ⬇️his risk + even reverse his T2DM if possible

It was!

Supported by his wife, he reversed his diabetes in only 11 weeks by cutting out sugar #LCHF 👍
3/7 With @lowcarbGP our little practice (9,800 patients) in Southport 🇬🇧has helped nearly 100 people reverse their Type 2 diabetes in the last 5 years
It's not rocket science 🚀

It's simply about cutting out the sugar + starchy carbs (cereals, bread, pasta, rice + potatoes)
Read 7 tweets
8 Apr
1/11 Many people cut out sugar + carbs as a way of reversing type 2 diabetes, pre-diabetes or improving their health #LCHF
At a recent group consultation many of my patients shared worries about how to avoid carbs in restaurants as 🇬🇧emerges from lockdown

Here are my top tips👇 Image
2/11 Think carefully about your choice of restaurant - some may be easier to manage than others Image
3/11 Put aside time to think about the meal in advance

It's hard to think clearly when arriving in a busy restaurant

"If you fail to plan, you plan to fail"

Try looking at the menu online before you go and have a think about your food and drink choices before you arrive Image
Read 11 tweets
6 Feb
1/8 Continuous Glucose Monitors (CGM) and *type 2* diabetes - can they help?🤔

A short thread...

Over the last 2 years I've found a 2-4 week opportunity for my patients to learn how their body reacts to different foods can be invaluable

But @NICEComms don't recommend in T2DM☹️
2/8 CGMs have revolutionised monitoring of type 1 diabetes. Currently recommended by @NICEComms only for some *not all* with type 1 eg:

Frequent asymptomatic hypos >2x/week
Severe hypos >1x/yr
Loss of awareness of hypos
Very poor control

See 👇nice.org.uk/guidance/ng17/…
3/8 My practice has now helped 92 people reverse their type 2 diabetes using dietary change; cutting out sugar + starchy carbs

It's not rocket🚀science, see my previous thread on how it can be done👇

Here's our published research👇
nutrition.bmj.com/content/early/…
Read 8 tweets
18 Jan
1/4 A baffling type 2 diabetes mystery

Can anyone help?

A brief thread..

This patient of mine is 55 and has mysteriously reversed her type 2 diabetes with a huge drop of HbA1c from 77➡️32mmol/mol (9.2-5.1%) in only 3 months

She is not on any new medications for her diabetes..
2/4 She swears she has NOT made any dietary changes EXCEPT cutting out all sources of sugar like sweets🍬, biscuits🍪, chocolate, cake🧁, fruit juice🧃 + avoiding starchy carbs such as bread🍞, cereals🥣, potatoes🥔, rice🍚+ pasta🍝

I really believe she is telling me the truth🤔
3/4 It's particularly spooky👻because she's the 88th person at my practice to whom this has happened

@lowcarbGP is baffled too🤔

Neither of us can explain it apart form the curious coincidence they've all⬇️their sugar + carb intake

Guess it may just have to remain a mystery 🤷‍♂️
Read 4 tweets
14 Nov 20
1/10 Pre-Diabetes 🤔

On #WorldDiabetesDay perhaps we should spend some time thinking about *preventing* type 2 diabetes

Here's a short thread on what I think folk should know about pre-diabetes

References at end

#MedTwitter #tweetorial #LCHF
2/10 Pre-diabetes has many names, often with subtle differences in definition

It's often called:

Impaired glucose tolerence, IGT
Impaired fasting glycaemia
Intermediate hyperglycaemia (preferred by @WHO )
High Risk State of Developing Diabetes (preferred by @AmDiabetesAssn )
3/10 Pre-diabetes is *NOT A DISEASE*

This is really important

It's a *RISK FACTOR* for developing type 2 diabetes

Other risk factors include:

Age >40 (>25 if S Asian)
Family History
Being overweight
People of Asian, African-Caribbean or black African origin, even if born in🇬🇧
Read 10 tweets
3 Nov 20
1/11 I think that the most important piece of research since 2017 about putting #type2diabetes into remission was published today in @BMJNutrition

The results are simply astonishing 😲

A twitter thread.... #MedTwitter #LCHF

Here's the paper👇

nutrition.bmj.com/content/early/…
2/11 The study is by @lowcarbGP @jen_unwin + others and looks at reversing T2DM and pre-diabetes by lifestyle change, in particular by ⬇️sugar and starchy carbs
3/11 The study builds on the work of Prof Roy Taylor's DiRECT Study which found that *severe* calorie restriction could put T2DM into remission👍
More info here 👇
directclinicaltrial.org.uk

This was great news but SO many people find calorie restriction IMPOSSIBLE TO SUSTAIN 🤔🤷‍♂️
Read 11 tweets

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