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Vinod Scaria Profile picture
@vinodscaria
Jun 6, 2021 • 9 tweets • 4 min read • Read on X
Scrolly
Interesting preprint on the antibody response after ChAdOx1-nCOV (Covishield) and BBV-152 (Covaxin) among Health Care Workers. (N=552 Covishield =456; Covaxin=96)
Both vaccines elicited👍immune response after 2nd dose. Seropositivity Covishield >Covaxin
medrxiv.org/content/10.110… Image
A number of factors include Age, Sex. Comorbidity including T2DM and Hypertension influence the antibody titres (Day 21-36 after 2nd dose) Image
More reasons why we should be eagerly looking forward to the Phase 3 data for Covaxin
Another preprint now online on Immunogenicity of the ChAdOx1 nCoV-19 and the BBV152 Vaccines in Patients with Autoimmune Rheumatic Diseases.
papers.ssrn.com/sol3/papers.cf… Image
The data also has healthy controls in comparison where the Ab titres have been examined. While small numbers cannot really ascertain the differences, the Median & IQR values show the same trend in Covaxin vs Covishield Image
And many other issues with the preprint has been summarised journosdiary.com/2021/06/06/cov…
Meanwhile in a parallel universe Image
A new preprint comparing the neutralization against B.1.351 and B.1.617.2 compared to B.1 with sera of COVID-19 recovered cases and vaccinees of BBV152
biorxiv.org/content/10.110…

Thanks @shananalla for pointing this out. Image
One cannot but agree to the very fact as stated on conflicts of interest section. Image

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More from @vinodscaria

Vinod Scaria Profile picture
Jul 8
#Zika virus outbreaks in #India. Should we be worried ?
A long 🧵 Image
#Zika is not a new virus.

🔴We have known it for decades, and India has seen previous, albeit small outbreaks in multiple states. Gujarat, Rajasthan, Kerala, Maharashtra and Uttar Pradesh, MP, TamilNadu , Delhi, Punjab, Telengana and Jharkhand in the previous years. Image
🔴This year, we have a multi-state outbreak with cases reported from Karnataka, Kerala and at least three districts in Maharashtra.

🔴The actual number of cases are unknown as there is no public tracker yet and the known is possibly just a small fraction of the disease burden. Image
Read 21 tweets
Vinod Scaria Profile picture
Jun 11, 2023
🔴 #Mpox aka #Monkeypox is spreading .
But not where you think it is.
A short 🧵 Image
The latest situation report on the multi-country outbreak of #mpox from @WHO has come out . In Summary:
▶️ 87,929 cases and 146 deaths from Jan 2022
▶️ 111 countries / territories affected as of date Image
▶️ The European and American Outbreak of #mpox which followed a super spreader event last year is pretty well under control.
There are few cases still being reported, but vaccination campaigns have brought the outbreak pretty well under control. Image
Read 13 tweets
Vinod Scaria Profile picture
Jun 10, 2023
🔴 Characterisation of #Influenza A #H3N8 with hallmarks of continued evolution, spread in poultry and occasional spillover to humans from #China 🇨🇳

journals.asm.org/doi/10.1128/jv…
▶️ Continued infection of poultry and spillover into humans could potentially accelerate evolution and adaptation to human to human tranmission
▶️ Adaptation to other mammals noted in the past, through evolutionary processes.
▶️ Genome analysis suggest the origin by reassortment of genomes from poultry H9N2 backbone
Read 7 tweets
Vinod Scaria Profile picture
Dec 21, 2022
#COVID19 in #China.
What we know and what we don't.
A long thread, summarizing my thoughts, which I hope to keep updated over the coming weeks. Image
To give a brief background:
The aggressive approach by #China to contain the virus following initial cases in Wuhan, has been seen with awe and admiration by man.
This included:
🔴Strict quarantine & lockdown
🔴Massive testing & surveillance
🔴Early vaccines
🔴Health Infra
While COVID19 spread across the rest of the world, infecting and killing millions of people, and putting healthcare infrastructure to the brim of their capacities, China remained isolated, contained the spread and remained an outlier in many aspects.
Data @WHO Image
Read 13 tweets
Vinod Scaria Profile picture
Oct 13, 2022
🔘Recombinant variants of SARS-CoV-2 and XBB/XBB.1 the recent and emerging recombinant variants with large immune evasive potential.
A short 🧵on emerging evidence. Image
Recombinant variants of viruses are generated when two or more viruses co-infect a cell at the same time. Chances for co-infection is rare, but nevertheless they occur.
Genomic surveillance can efficiently pick up such recombinant isolates. Image
There are 49 odd recombinant variants now catalogued for #SARSCoV2 by @PangoNetwork , an open collaboration of scientists across the world.
PANGO names recombinant variants of #SARSCoV2 with a name starting with 'X'. Image
Read 21 tweets
Vinod Scaria Profile picture
Jul 27, 2022
🔴The curious case of Indian #Monkeypox Genomes
Wonderful effort by clinicians in @KeralaHealth who diagnosed the disease and researchers at @icmr_niv, we now have sequences of MPX isolates in @GISAID .

This short 🧵is on what the early genomes say.
Analysis @bani_jolly
Briefly 4⃣ genome sequences have been deposited for two samples (EPI_ISL_13953610 and EPI_ISL_13953611) along with 2 re-sequenced genomes from isolates of one of the sample.
▶️Both the isolates were from early cases reported from Kerala
▶️Both cases have a travel history
The present sustained human-human transmission of the MPX virus is believed to have happened via superspreader events in Europe with 16000+ cases now spread across 70+ countries,
The initial cases seemingly were predominantly among gays/bisexuals and msm networks
Read 13 tweets

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