Metabolic syndrome and non-alcoholic fatty liver disease are essentially two definitions of the same problem.

You definitely want to avoid fatty liver…
Substituting starch for sugar, at the same calorie intake, cut liver fat in half, in 9 days.

Evidence points to sugar (fructose) as causing fatty liver…
Higher protein diet, 30% protein, either animal or plant protein, decreased liver fat

40% carbs, lower than what most people eat but not "low carb", could also contribute to less liver fat.…
Type 2 diabetes and metabolic syndrome are reversible by decreasing liver fat.

Diets lower in sugar/carbs and higher in protein can do this.

Should be standard of care and this knowledge needs to be spread.

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More from @Mangan150

7 Jun
N-acetylcysteine is a safe, effective, and cheap OTC supplement that's been shown useful in many different health conditions.

That's why the FDA doesn't want you to have it.
Here's an example of why n-acetylcysteine irks the establishment:

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients


Authors specifically mention how cheap NAC is:
"A monthly supply of 600-mg NAC capsules... costs $15–30 on the retail market... sharply contrasts with the estimated average annual direct medical costs of ∼$22,580 per patient in 2009. Thus, the cost of NAC at $180–360/year would be negligible" compared to lupus burden.
Read 5 tweets
31 May
VO2max, or total aerobic power, is tightly correlated to blood volume and total hemoglobin.… Image
When untrained men trained for 6 weeks, VO2max and peak cardiac output increased, but the increase was abolished by calibrated phlebotomy to bring their blood volume back to baseline.…
Why does this matter? Because continuous aerobic training is not some kind of super-special training modality.

Any exercise that causes sufficient muscular work will increase VO2max.
Read 7 tweets
20 May
Oxidative stress, or an imbalance between free radicals and endogenous (self-made) antioxidants, increases in aging.

It leads to constant, low-level insulin receptor activation and failure to activate autophagy.…
Fortunately, there's a way to fix this: exercise.

One of the most important ways in which exercise improves health is by increasing endogenous antioxidant production.

Exercise is a stress which the body recognizes by increasing its stress defenses.…
Older people have an attenuated antioxidant response to an acute bout of exercise, compared to young people.

But regular training can overcome this.…
Read 5 tweets
20 May
Hormesis, the process in which stressors such as exercise or sun exposure result in better health, points to a larger principle:

excessive comfort is bad for you.

In the modern era, you need to seek out discomfort.
Insulating ourselves from natural rhythms is one of the main factors behind the diabesity epidemic.

Rhythms like:


We're basically attempting to be comfortable all the time.

Too much comfort = disease.
The problem with the modern world in terms of health is that we humans *like* being lazy, we *like" energy-dense foods with sugar and carbs and fat.

We *like* sitting on our backsides.

We've evolved to like those things.

And the modern world has stepped up to provide them.
Read 4 tweets
16 May
Zinc supplementation hugely reduces infection rates in the elderly.

But, is this from correcting a poor diet, or offsetting aging, or both?
As we age, our thymus gland, which is critical to immunity, shrinks dramatically.

But in old mice, zinc supplementation can regrow the thymus, with a full recovery of thymus function.

This could be why zinc helps human immunity in the elderly.…
A number of different experimental treatments that regrow the thymus are all thought to involve zinc.

So it would appear that zinc supplementation as you get older could help maintain immune function and resistance to infections and cancer.…
Read 5 tweets
14 May
Blood clotting and long, healthy life.

A loss-of-function mutation in the gene that encodes for PAI-1 is associated with lower fasting insulin, and...

7 years longer lifespan - huge.

Thread 👇…
PAI-1 is plasminogen activator inhibitor, and increased levels mean less fibrinolysis, and a tendency for blood to remain clotted.

Increased PAI-1 is associated with obesity, particularly visceral fat.…
Patients with peripheral arterial disease have higher PAI-1, and exercise training significantly reduces it.…
Read 6 tweets

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