Thread by @kegill

Promising research into metastatic #breastcancer from the UK in @Nature

The FDA-approved antibiotic Bedaquiline (for multi-drug resistant tuberculosis) “downregulated ATP5F1C expression in vitro and prevented spontaneous metastasis in vivo”

nature.com/articles/s4141…

Bedaquiline prevented “spontaneous metastasis in a xenograft model, without affecting tumor growth, or inducing significant toxicity… consistent with the idea that ATP is a functional biomarker of metastasis.”

Small study: 12 female patients with a diagnosis of invasive breast carcinoma. Samples of lymph node metastasis (5) or distant metastasis alone (6). One sample included the primary tumor; axillary lymph nodal metastasis; plus skin and the liver metastases.

Researchers were also “able to successfully down-regulate ATP5F1C expression in an inducible manner, by using low levels of Doxycycline.”