Maximizing potential benefit of vaccine donations depends on doses going where they can do the"most good" but there's no consensus on where that would be

Murray @IHME_UW @RCReinerJr & I propose an approach that prioritizes epidemiology over geopolitics 1/
thelancet.com/journals/lance…
This week's summit in Cornwall, UK should be the time when G7 leaders finally act on their promises to send surplus COVID-19 vaccine supplies to the many other countries where they remain scarce #G7UK

But how will those vaccine donations be allocated? 2/
bloomberg.com/news/articles/…
COVAX has been criticized by @ZekeEmanuel @GovindPersad & others for its population-based allocation scheme that does not direct most of its early vaccine supplies to the settings at the greatest risk of otherwise having high COVID-19 death rates 3/
nytimes.com/2021/05/24/opi…
COVAX organizers argue ensuring each country can vaccinate ~20% of its people makes sense given uncertainty a/b where next surge or variant will occur

Yet donors may find it difficult to wait to respond to pleas from specific countries w/surging cases 4/
nytimes.com/2021/05/27/opi…
Nations donating COVID-19 vaccines bilaterally have
not done any better in prioritizing urgent health needs

See @samckiernan @serena_tohme and others in @ThinkGlobalHlth 5/
thinkglobalhealth.org/article/politi… Image
Without compelling metric of where greatest health benefit may be gained from donations, G7 policymakers are likely to split difference

Send some spare doses to COVAX’s population-based scheme

Send rest to allies, trade partners & strategic interests 6/
Whether donated through #COVAX or bilaterally, spare COVID-19 vaccine doses should be allocated to reduce the most premature deaths

Although it's impossible to know for certain where future COVID deaths will occur, it is possible to anticipate impending needs in this pandemic 7/
Our @TheLancet analysis shows greatest needs are likely to be in those areas have received fewest COVID-19 vaccine donations so far:

Countries in Latin America, Central Asia, and Central and Eastern Europe and South Africa & Namibia 8/
thelancet.com/journals/lance… Image
President Biden promised not to use donated doses “to secure favors from other countries” but to follow "science and the public health data”

This is a commitment that the USA should keep and other G7 nations should adopt

Here's how:
thelancet.com/journals/lance… Image

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More from @TomBollyky

27 Mar
Recent US pledge of 2.5 M vaccine doses to Mexico is notable:

-It's the largest single bilateral pledge of doses so far in this crisis

- It's going to a nation in great need

- It came from a democracy

Here's me in @TheAtlantic on why that matters 1/
theatlantic.com/ideas/archive/…
So far, 14 countries have donated a total of 22.5 million doses to 97 nations

Most donations outside of Asia-Pacific have been too small (150k doses or less) to meet local or global demands

2/
thinkglobalhealth.org/article/politi…
Vaccine donations are distributing fewer doses than COVAX (22.5 million v. 32 million) but they are going to more countries (97 v. 60).

Yet, many of those donations are not going to the poorer nations most in need of doses 3/

thinkglobalhealth.org/article/politi…
Read 8 tweets
20 Jan
President-elect Biden has set a goal of vaccinating 100 million Americans (30% of the population) in 100 days.

It is an ambitious, achievable goal.

Here is what that will require, via @JenniferNuzzo, Sid Baccam @IEMNews, and me in the @nytimes 1/
nytimes.com/2021/01/20/opi…
Primary constraint on vaccinating more Americans so far has not been supply

Despite production shortfalls, US still distributed close to enough doses to vaccinate average of 1M people daily

Bigger hurdles have been administration & demand 2/
covid.cdc.gov/covid-data-tra…
Reaching 1 million people per day requires expanding beyond vaccinating small number of individuals on scheduled-basis to doing more mass vaccination

After 9/11, federal gov't thought through how to vaccinate many Americans in a short time 3/
liebertpub.com/doi/pdf/10.108…
Read 10 tweets
30 Dec 20
Good news! Vaccine is relatively cheap, easy to produce & store, well tolerated. 3B doses projected in 2021

Haven't seen submission or decision, but MHRA reportedly approved 2 dose regimen (62% effective) & is encouraging a 1-dose regimen to speed access
Results published in Lancet indicate say this a/b 1 dose regimen

It will be interesting to see public response and distribution strategy for regimen w/lower efficacy than Pfizer/Moderna options & uncertainty about duration of protection
thelancet.com/journals/lance…
Apparently, Oxford/AstraZeneca has not even filed a submission package with EMA yet. FDA decision isn't coming soon either.

This is such an important vaccine for global access and so much is strange about how its sponsors have pursued it
reuters.com/article/us-hea…
Read 4 tweets
29 Dec 20
Revolutions often go full circle, recreating circumstances that led to initial upheaval

For 2d time in 20 yrs world faces a treatment access crisis

1st crisis transformed #globalhealth but laid seeds for latest crisis over vaccines

My latest w/@ChadBown
foreignaffairs.com/articles/world…
20 yrs ago, crisis over AIDS drugs brought deep & lasting changes, pumping $$ into R&D of new meds & creating new institutions to deliver them

But it also shifted focus of #globalhealth 2/

foreignaffairs.com/articles/world…
Global health became less a/b cooperation among nations on common threats and more a/b aid-driven initiatives and public-private partnerships to solve the problems of *other* people—mostly in low-income countries 3/
Read 7 tweets
14 Nov 20
Interim results on Pfizer vaccine are promising

But getting safe doses to those who would benefit most depends on reversing a trend that has defined this pandemic:

to quote Isaac Asimov, “science gathers knowledge faster than society gathers wisdom” 1/
theatlantic.com/ideas/archive/…
US #COVID19 hospitalizations & deaths are surging, and projections are ~200,000 more Americans will lose their lives to the virus before March

A safe vaccine could help shift that trajectory but only if we learn from past US failures distributing vaccines to adults 2/
According to recent analysis, 75% Americans would need to receive a vaccine that prevents at least 80% of infections for that vaccine to end #COVID19 pandemic on its own

(h/t @PeterHotez) 3/
ajpmonline.org/article/S0749-…
Read 16 tweets
23 Oct 20
Countries without government trust have performed badly in #COVID19, even when you account for differences in population age and size, and the timing of the pandemic

New analysis in @ForeignAffairs via @samckiernan, Sawyer Crosby @IHME_UW, and me 1/
foreignaffairs.com/articles/unite…
“Government exists to protect us from each other,” Reagan once said, but goes “beyond its limits . . . in deciding to protect us from ourselves”

When applied to pandemics, Reagan was wrong & so are policymakers, in esp. in US, who have adopted this view
foreignaffairs.com/articles/unite…
Confronted w/novel contagious virus, for which there's no effective treatment & no preexisting immunity, the only way to protect citizens from one another is by convincing them to protect themselves

Esp. in free societies that depends on trust between government and its people
Read 15 tweets

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